Long-Term Antibacterial Film Nanocomposite Incorporated with Patchouli Essential Oil Prepared by Supercritical CO2 Cyclic Impregnation for Wound Dressing

Jia, Jinping; Duan, Shulei; Zhou, Xue; Sun, Li; Qin, Chao; Li, Ming; Ge, Fahuan

doi:10.3390/molecules26165005

Cited by 18 publications

(19 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Its essential oil is widely utilized in several industries, including perfumery and cosmetic products such as deodorants, soaps and detergents [ 11 ]. Furthermore, patchouli essential oil has a variety of pharmacological and medicinal activities, including antimicrobial, anti-inflammatory and anti-cancer effects, in addition to improving gastrointestinal function and enhancing memory [ 12 ]. This essential oil is conventionally obtained by steam distillation of the plant biomass that includes non-fermented dried leaves.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of Novel Patchouli Essential Oil Loaded Starch-Based Hydrogel

Khalil

Muhammad

Yahya

et al. 2022

Gels

View full text Add to dashboard Cite

Starch hydrogels are highly available, biocompatible and biodegradable materials that have promising applications in medical and pharmaceutical industries. However, their applications are very limited due to their poor mechanical properties and fragility. Here, we investigated, for the first time, conventional corn and waxy corn starch-based hydrogels for loading patchouli essential oil. The essential oil extracted by supercritical carbon dioxide with a yield reached 8.37 ± 1.2 wt.% (wet sample) at 80 °C temperature and 10 MPa pressure. Patchouli essential oil exhibited a 23 to 28 mm zone of inhibition against gram-positive and gram-negative bacteria. Waxy starch hydrogels had better properties in term of viscosity, water evaporation stability and the delivery of essential oil than conventional starch hydrogels. The viscosity and spreadability of a 6% waxy starch sample were 15,016 ± 59 cP and 4.02 ± 0.34 g·cm/s, respectively, compared with those of conventional starch hydrogel (13,008 ± 29 cP and 4.59 ± 0.88 g·cm/s). Waxy starch-based hydrogels also provided slower in vitro biodegradation behavior and sustained release of essential oil compared with conventional starch hydrogels. All the samples were biocompatible and non-cytotoxic to fibroblast cells; the addition of patchouli essential oil enhances the proliferation of the cells. The enhanced viscosity, good antibacterial and improved biocompatibility results of prepared hydrogels confirm their suitability for wound healing applications.

show abstract

Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of Novel Patchouli Essential Oil Loaded Starch-Based Hydrogel

Khalil

Muhammad

Yahya

et al. 2022

Gels

View full text Add to dashboard Cite

show abstract

“…This feature of DAIs lays the basis for the development of antibacterial surfaces with long active durations. As shown by the representative reports on the development of “ long-term ” antibacterial surfaces ( Table 5 ) [ 121 , 122 , 123 , 124 , 125 , 126 , 127 , 128 , 129 , 130 , 131 , 132 , 133 , 134 , 135 , 136 , 137 , 138 , 139 ], various ingredients such as commercial antibiotics (tigecycline, vancomycin, amoxicillin, etc.) [ 121 , 132 ], metals or metal ions (silver, copper, or zinc) [ 124 , 125 , 129 ], and other drugs [ 127 , 128 ] were taken to equip implantable biomaterials (titanium, silicone, ceramics, etc.)…”

Section: Innovative Designs To Mitigate Device-associated Infectionsmentioning

confidence: 99%

“…As shown by the representative reports on the development of “ long-term ” antibacterial surfaces ( Table 5 ) [ 121 , 122 , 123 , 124 , 125 , 126 , 127 , 128 , 129 , 130 , 131 , 132 , 133 , 134 , 135 , 136 , 137 , 138 , 139 ], various ingredients such as commercial antibiotics (tigecycline, vancomycin, amoxicillin, etc.) [ 121 , 132 ], metals or metal ions (silver, copper, or zinc) [ 124 , 125 , 129 ], and other drugs [ 127 , 128 ] were taken to equip implantable biomaterials (titanium, silicone, ceramics, etc.) with prolonged antibacterial efficacy, ranging from days [ 127 , 131 , 133 ] to months [ 122 , 134 ].…”

Section: Innovative Designs To Mitigate Device-associated Infectionsmentioning

confidence: 99%

“…[ 121 , 132 ], metals or metal ions (silver, copper, or zinc) [ 124 , 125 , 129 ], and other drugs [ 127 , 128 ] were taken to equip implantable biomaterials (titanium, silicone, ceramics, etc.) with prolonged antibacterial efficacy, ranging from days [ 127 , 131 , 133 ] to months [ 122 , 134 ]. Extending the release period of the antimicrobials is currently a major pathway leading to “ long-term ” antibacterial surfaces.…”

Section: Innovative Designs To Mitigate Device-associated Infectionsmentioning

confidence: 99%

See 1 more Smart Citation

Antibacterial Designs for Implantable Medical Devices: Evolutions and Challenges

Cao

Qiao

Qin

2022

JFB

View full text Add to dashboard Cite

The uses of implantable medical devices are safer and more common since sterilization methods and techniques were established a century ago; however, device-associated infections (DAIs) are still frequent and becoming a leading complication as the number of medical device implantations keeps increasing. This urges the world to develop instructive prevention and treatment strategies for DAIs, boosting the studies on the design of antibacterial surfaces. Every year, studies associated with DAIs yield thousands of publications, which here are categorized into four groups, i.e., antibacterial surfaces with long-term efficacy, cell-selective capability, tailored responsiveness, and immune-instructive actions. These innovations are promising in advancing the solution to DAIs; whereas most of these are normally quite preliminary “proof of concept” studies lacking exact clinical scopes. To help identify the flaws of our current antibacterial designs, clinical features of DAIs are highlighted. These include unpredictable onset, site-specific incidence, and possibly involving multiple and resistant pathogenic strains. The key point we delivered is antibacterial designs should meet the specific requirements of the primary functions defined by the “intended use” of an implantable medical device. This review intends to help comprehend the complex relationship between the device, pathogens, and the host, and figure out future directions for improving the quality of antibacterial designs and promoting clinical translations.

show abstract

“…A suitable covering, which protects wound infection and provides an appropriate wound environment, is one of the important factors for the reduction of delayed wound healing [ 7 ]. Many wound dressings are developed to provide a competitive advantage during wound healing, such as providing protection against infection, keeping the wound moist, elimination of exudate, wound healing acceleration, mechanical protection, easy removal, biocompatibility, biodegradation, and non-toxicity [ 8 , 9 , 10 , 11 , 12 ]. The number of chronic wounds has risen following an increase in the elderly and diabetic population [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

Superior Technique for the Production of Agarose Dressing Containing Sericin and Its Wound Healing Property

Napavichayanun

Pienpinijtham

Reddy³

et al. 2021

Polymers

View full text Add to dashboard Cite

Finding a simple and eco-friendly production technique that matches to the natural agent and results in a truly valuable natural scaffold production is still limited amongst the intensively competitive natural scaffold development. Therefore, the purpose of this study was to develop natural scaffolds that were environmentally friendly, low cost, and easily produced, using natural agents and a physical crosslinking technique. These scaffolds were prepared from agarose and sericin using the freeze-drying method (D) or freeze-thawing together with the freeze-drying method (TD). Moreover, plasticizers were added into the scaffold to improve their properties. Their physical, mechanical, and biological properties were investigated. The results showed that scaffolds that were prepared using the TD method had stronger bonding between sericin and other compounds, leading to a low swelling ratio and low protein release of the scaffolds. This property may be applied in the development of further material as a controlled drug release scaffold. Adding plasticizers, especially glycerin, into the scaffolds significantly increased elongation properties, leading to an increase in elasticity of the scaffold. Moreover, all scaffolds could activate cell migration, which had an advantage on wound healing acceleration. Accordingly, this study was successful in developing natural scaffolds using natural agents and simple and green crosslinking methods.

show abstract

Long-Term Antibacterial Film Nanocomposite Incorporated with Patchouli Essential Oil Prepared by Supercritical CO2 Cyclic Impregnation for Wound Dressing

Cited by 18 publications

References 32 publications

Synthesis and Characterization of Novel Patchouli Essential Oil Loaded Starch-Based Hydrogel

Synthesis and Characterization of Novel Patchouli Essential Oil Loaded Starch-Based Hydrogel

Antibacterial Designs for Implantable Medical Devices: Evolutions and Challenges

Superior Technique for the Production of Agarose Dressing Containing Sericin and Its Wound Healing Property

Contact Info

Product

Resources

About