Long-term antibacterial activity of guanidinium carbon dots without detectable resistance for the effective treatment of pneumonia caused by Gram-negative bacteria

Zhang, Xintian; Bai, Xinxin; Deng, Xiaoqin; Peng, Kai; Zheng, Zongfu; Xiao, Jiecheng; Zhang, Rui; Huang, Zhengjun; Huang, Jianyong; Chen, Min; Weng, Shaohuang

doi:10.1016/j.carbon.2023.118229

Cited by 7 publications

(2 citation statements)

References 84 publications

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“…Figure 8 b delineates the antibacterial mechanism of the Arg-PES membrane. The positively charged guanidine groups establish robust hydrogen bonds with the negatively charged phosphates present on the bacterial cell membrane [ 33 , 45 ]. This interaction induces perturbation in the phospholipid bilayer, ultimately leading to membrane rupture.…”

Section: Resultsmentioning

confidence: 99%

Arginine-Functionalized Thin Film Composite Forward Osmosis Membrane Integrating Antifouling and Antibacterial Effects

Chen,

Yu,

Cao

2023

Membranes

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Membrane fouling is an inevitable obstacle of polyamide composite forward osmosis (FO) membranes in oily wastewater treatment. In this study, zwitterionic arginine (Arg) is grafted onto nascent self-made FO polyamide poly(ether sulfone) (PA-PES) membrane, imparting superior hydrophilic, antifouling, and antibacterial properties to the membrane. Detailed characterizations revealed that the Arg-modified (Arg-PES) membrane presented obviously surface positively charged and unique morphology. Results showed that our strategy endowed the optimized membrane, the water flux increased by 113.2% compared to the pristine membrane, respectively, meanwhile keeping high NaCl rejection > 93.9% (with DI water as feed solution and 0.5 M NaCl as draw solution, FO mode). The dynamic fouling tests indicated that the Arg-PES membranes exhibited much improved antifouling performance towards oily wastewater treatment. The flux recovery ratios of the membrane were as high as 92.0% for cationic emulsified oil (cetyl pyridinium chloride, CPC), 87.0% for neutral emulsified oil (Tween-80), and 86.0% for anionic emulsified oil (sodium dodecyl sulfate, SDS) after washing, respectively. Meanwhile, the Arg-PES membranes assembled with guanidine cationic groups exhibited an enhanced antibacterial property against E. coli, which exhibited a high antibacterial efficiency of approximately 96%. Consequently, the newly arginine functionalized FO membrane possesses impressive antifouling performance, while simultaneously resisting bacterial invasion, thus rendering it an ideal alternative for oily wastewater treatment in the FO process.

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Section: Resultsmentioning

confidence: 99%

Arginine-Functionalized Thin Film Composite Forward Osmosis Membrane Integrating Antifouling and Antibacterial Effects

Chen,

Yu,

Cao

2023

Membranes

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“…For example, guanidinium-based carbon dots (G-CDs) acted on bacterial cell walls and cell membranes through van der Waals force, electrostatic adsorption and hydrogen bonding. 98 The small-sized G-CDs entered the bacterial cells to generate appropriate amounts of ROS, adsorb DNA, and interact with each other to cause physiological and genetic effects on the bacteria, showing excellent therapeutic effects in a mouse pneumonia model of E. coli infection. Jian et al found that CQD Spds had an excellent antibacterial effect and did not have side effects of aggravating inflammation and oxidative damage to cells.…”

Section: Applications Of Fcds In Bacterial Inflammationmentioning

confidence: 99%

Antibacterial functionalized carbon dots and their application in bacterial infections and inflammation

Fang,

Lin,

Zheng

et al. 2023

J. Mater. Chem. B

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Insight into the synthetic strategies of carbon dots and its Structure-Property interplay for Next-Generation technologies

Liu,

Xu,

Wang

et al. 2024

Chemical Engineering Journal

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Long-term antibacterial activity of guanidinium carbon dots without detectable resistance for the effective treatment of pneumonia caused by Gram-negative bacteria

Cited by 7 publications

References 84 publications

Arginine-Functionalized Thin Film Composite Forward Osmosis Membrane Integrating Antifouling and Antibacterial Effects

Arginine-Functionalized Thin Film Composite Forward Osmosis Membrane Integrating Antifouling and Antibacterial Effects

Antibacterial functionalized carbon dots and their application in bacterial infections and inflammation

Insight into the synthetic strategies of carbon dots and its Structure-Property interplay for Next-Generation technologies

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