Antibacterial functionalized carbon dots and their application in bacterial infections and inflammation

Fang, Meng; Lin, Liping; Zheng, Muyue; Liu, Wei; Lin, Rongguang

doi:10.1039/d3tb01543b

Cited by 12 publications

(5 citation statements)

References 111 publications

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“…The photophysics of the CD reported here is dominated by not only their intrinsic photoluminescence but also their nonradiative transitions, leading to ROS generation upon visible light irradiation. This makes them interesting candidates as sensitizers for photodynamic therapy applications including photoactivated microbial annihilation . The ROS generation ability of the CD is retained after its conjugation with gelatin and thus is translated to the bioadhesive.…”

Section: Resultsmentioning

confidence: 99%

“…This makes them interesting candidates as sensitizers for photodynamic therapy applications including photoactivated microbial annihilation. 49 The ROS generation ability of the CD is retained after its conjugation with gelatin and thus is translated to the bioadhesive. This essentially points out the selfsterilization ability of the bioadhesive to prevent infection at the wound site just through exposure to visible light for a short time.…”

Section: Hemin Encapsulation In the Cd−gelatin Bioadhesive And Fluore...mentioning

confidence: 99%

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Multifunctional Self-Healing Carbon Dot–Gelatin Bioadhesive: Improved Tissue Adhesion with Simultaneous Drug Delivery, Optical Tracking, and Photoactivated Sterilization

Aggarwal,

Panigrahi,

Kotnees

et al. 2024

Biomacromolecules

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Bioadhesives with all-inclusive properties for simultaneous strong and robust adhesion, cohesion, tracking, drug delivery, self-sterilization, and nontoxicity are still farfetched. Herein, a carbon dot (CD) is made to infuse each of the above-desired aspects with gelatin, an inexpensive edible protein. The CD derived through controlled hydrothermal pyrolysis of dopamine and terephthaldehyde retained −NH 2 , −OH, −COOH, and, most importantly, −CHO functionality on the CD surface for efficient skin adhesion and cross-linking. Facile fabrication of CD−gelatin bioadhesive through covalent conjugation of −CHO of the CD with −NH 2 of gelatin through Schiff base formation was accomplished. This imparts remarkable self-healing attributes as well as excellent adhesion and cohesion evident from physicomechanical analysis in a porcine skin model. Improved porosity of the bioadhesive allows loading hemin as a model drug whose disembarkment is tracked with intrinsic CD photoluminescence. In a significant achievement, antibiotic-free self-sterilization of bioadhesive is demonstrated through visible light (white LED, 23 W)-irradiated photosensitization of the CD to produce reactive oxygen species for annihilation of both Gram-positive and Gram-negative bacteria with exceptional efficacy (99.9%). Thus, a comprehensive CD− gelatin bioadhesive for superficial and localized wound management is reported as a promising step for the transformation of the bioadhesive domain through controlled nanotization for futuristic clinical translations.

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Section: Resultsmentioning

confidence: 99%

Section: Hemin Encapsulation In the Cd−gelatin Bioadhesive And Fluore...mentioning

confidence: 99%

Multifunctional Self-Healing Carbon Dot–Gelatin Bioadhesive: Improved Tissue Adhesion with Simultaneous Drug Delivery, Optical Tracking, and Photoactivated Sterilization

Aggarwal,

Panigrahi,

Kotnees

et al. 2024

Biomacromolecules

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“…An additional advantage of CDs is that they are nontoxic and will not lead to the development of resistance in bacteria. CDs generally act at the solid–liquid interface. − CD-based materials have proven effective against pathogenic and spoilage bacteria in food by inhibiting planktonic bacteria and biofilms. Optimization of the production parameters of CDs can help them achieve a full-spectral response, but degradability still requires further research.…”

Section: Carbon Dots In Biofilm Treatmentmentioning

confidence: 99%

Biofilm Inhibition on Medical Devices and Implants Using Carbon Dots: An Updated Review

Priyadarshini,

Kumar,

Balakrishnan

et al. 2024

ACS Appl. Bio Mater.

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Biofilms are an intricate community of microbes that colonize solid surfaces, communicating via a quorum-sensing mechanism. These microbial aggregates secrete exopolysaccharides facilitating adhesion and conferring resistance to drugs and antimicrobial agents. The escalating global concern over biofilm-related infections on medical devices underscores the severe threat to human health. Carbon dots (CDs) have emerged as a promising substrate to combat microbes and disrupt biofilm matrices. Their numerous advantages such as facile surface functionalization and specific antimicrobial properties, position them as innovative anti-biofilm agents. Due to their minuscule size, CDs can penetrate microbial cells, inhibiting growth via cytoplasmic leakage, reactive oxygen species (ROS) generation, and genetic material fragmentation. Research has demonstrated the efficacy of CDs in inhibiting biofilms formed by key pathogenic bacteria such as Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa. Consequently, the development of CD-based coatings and hydrogels holds promise for eradicating biofilm formation, thereby enhancing treatment efficacy, reducing clinical expenses, and minimizing the need for implant revision surgeries. This review provides insights into the mechanisms of biofilm formation on implants, surveys major biofilm-forming pathogens and associated infections, and specifically highlights the anti-biofilm properties of CDs emphasizing their potential as coatings on medical implants.

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“…Moreover, through proper functionalization, carbon dots can enhance their existing physicochemical properties and explore new ones, thereby improving selectivity and sensitivity to targeted bacteria, expanding their applications to wound dressings, antibacterial coatings, food packaging, and eyedrops, showing significant potential for commercialization and diversification. [ 79 ] As a recent example, nitrogen and sulfur self‐doped antimicrobial carbon dots were synthesized using a straightforward one‐step hydrothermal method, employing garlic as the carbon source, renowned for its natural antibacterial properties. The results unveiled that the garlic‐derived carbon dots exhibited a positively charged surface, excellent fluorescence characteristics, and ultrafine particle size, aligning with typical carbon dot properties.…”

Section: Qds In Actionmentioning

confidence: 99%

Unlocking the Potential and Versatility of Quantum Dots: from Biomedical to Environmental Applications and Smart Micro/Nanorobots

Ussia,

Privitera,

Scalese

2024

Adv Materials Inter

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Quantum dots (QDs) are recognized as the most promising functional nanotechnology, for which its discoverers are awarded the Nobel Prize in 2023. Their remarkable tunability of optoelectronic properties has attracted significant interest from both researchers and industries, placing QDs at the forefront of developing cutting‐edge technologies. This comprehensive review aims to explore the exciting results in terms of fundamental science, present and forthcoming applications. Beyond their contributions to biomedicine, energy, environmental science, quantum sensing, and quantum information processing, QDs have brought important results due to their integration into micro/nanorobotic systems, self‐propelled materials representing the state of the art research at the micro and nanoscale. These hybrid systems have demonstrated noteworthy outcomes, unlocking novel possibilities in biomedicine, quantum sensing, and environmental science, accurately reviewed in this article. In conclusion, this review addresses current challenges, offering insights to facilitate further research, stimulate new developments, and enhance the comprehension of the full potential of QDs.

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Antibacterial functionalized carbon dots and their application in bacterial infections and inflammation

Abstract: Antimicrobial mechanisms of functionalized carbon dots: covalent and non-covalent interactions, reactive oxygen species, photothermal effect, and size effect (E. coli was used as a model).

Cited by 12 publications

References 111 publications

Multifunctional Self-Healing Carbon Dot–Gelatin Bioadhesive: Improved Tissue Adhesion with Simultaneous Drug Delivery, Optical Tracking, and Photoactivated Sterilization

Multifunctional Self-Healing Carbon Dot–Gelatin Bioadhesive: Improved Tissue Adhesion with Simultaneous Drug Delivery, Optical Tracking, and Photoactivated Sterilization

Biofilm Inhibition on Medical Devices and Implants Using Carbon Dots: An Updated Review

Unlocking the Potential and Versatility of Quantum Dots: from Biomedical to Environmental Applications and Smart Micro/Nanorobots

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