Long noncoding RNAs: Important participants and potential therapeutic targets for myocardial ischaemia reperfusion injury

Abstract

Myocardial ischaemia reperfusion (I/R) injury is one of the leading causes of coronary artery disease-associated morbidity and mortality. While different strategies have been used to limit I/R injuries, cardiac functions often do not recover to the normal level as anticipated. Recent studies have pointed to important roles of long noncoding RNAs (lncRNAs) in the development of myocardial I/R injury. LncRNA is a class of RNA molecules of more than 200 nucleotides in length which are not translated into proteins. I/R causes dysregulation of lncRNA expression in cardiomyocytes, thereby How to cite this article: Ding Y-M, Chan EC, Liu L-C, et al. Long noncoding RNAs: Important participants and potential therapeutic targets for myocardial ischaemia reperfusion injury.

[Retracted] Dysregulated Circulating Apoptosis‐ and Autophagy‐Related lncRNAs as Diagnostic Markers in Coronary Artery Disease

“…In comparison to the conventional diagnosed approach, circulating lncRNAs are noninvasive and innocuous, with highly sensitive and accurate advantages [30]. Furthermore, lncRNAs may participate in the progression of CAD via mediating apoptosis and autophagy, two forms of programmed cell deaths [15]. On account of these strengths, this study explored circulating lncRNAs related to apoptosis and autophagy for CAD diagnosis.…”

“…Both serum levels in CAD patients are higher than healthy controls [14]. lncRNAs with >200 nucleotides may participate in the pathophysiological processes of CAD including autophagy and apoptosis [15]. On account of their tissue and cell specificity, circulating lncRNAs are promising diagnostic markers for various diseases [15].…”

“…lncRNAs with >200 nucleotides may participate in the pathophysiological processes of CAD including autophagy and apoptosis [15]. On account of their tissue and cell specificity, circulating lncRNAs are promising diagnostic markers for various diseases [15]. A previous study has identified three lncRNAs including Chast, HULC, and DICER1-AS1 that are distinctly related to autophagy in blood circulation of CAD patients [16].…”

LncRNA HCP5 in hBMSC-derived exosomes alleviates myocardial ischemia reperfusion injury by sponging miR-497 to activate IGF1/PI3K/AKT pathway

“…Micro RNAs (miRNAs) and long non-coding RNAs (lncRNAs) are two important families of ncRNAs with lengths of ~21-24 nucleotides and exceeding 200 nucleotides, respectively [10]. In myocardial I/R injury, many studies have shown that both miRNAs and lncRNAs are largely involved [11,12]. For instance, lncRNA SNHG8 (small nucleolar RNA host gene 8) mediates myocardial muscle cell necrosis following I/R [13].…”

Clinicopathological and Prognostic Value of Necroptosis-Associated lncRNA Model in Patients with Kidney Renal Clear Cell Carcinoma

“…The lncRNA TRINGS interacts with STRAP and thwarts STRAP-GSK3 β -NF- κ B necrotic pathways [ 33 ]. Moreover, other studies have found that myocardial ischemia-reperfusion injury can lead to abnormal expression of lncRNAs in cardiomyocytes, thus affecting various cellular functions such as mitochondrial homeostasis, apoptosis, necrosis, and autophagy [ 34 ]. However, functions adopted by necroptosis-associated lncRNAs for treating or prognostic determination of KIRC are still unclear.…”