Long noncoding RNAs as biomarkers for the diagnosis of hepatocellular carcinoma: A meta-analysis

Zeng, Chuyi; Tang, Yan; Jiang, Yao; Zuo, Zhihua; Tao, Hualin

doi:10.1016/j.prp.2021.153546

Cited by 5 publications

(2 citation statements)

References 39 publications

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“…Interestingly, in the latter study, the combined measurement of lncRNA Linc00152 with AFP showed the best performance and high accuracy, whereas a combination of a panel of two lncRNAs, Linc00152 and UCA1, with AFP provided 82.9% sensitivity and 88.2% specificity in HCC diagnosis. Additionally, a meta-analysis, which included 52 studies that involved a total of 4930 patients and 4614 healthy controls has demonstrated feasibility of lncRNAs as HCC diagnostic biomarkers [ 67 ]. However, the authors of the latter study concluded that further investigations are necessary to confirm diagnostic and clinical value of lncRNA measurements.…”

Section: Del-dem-deg Network In Hccmentioning

confidence: 99%

Differentially expressed non-coding RNAs and their regulatory networks in liver cancer

Moldogazieva,

Zavadskiy,

Astakhov

et al. 2023

Heliyon

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Section: Del-dem-deg Network In Hccmentioning

confidence: 99%

Differentially expressed non-coding RNAs and their regulatory networks in liver cancer

Moldogazieva,

Zavadskiy,

Astakhov

et al. 2023

Heliyon

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“…With the advancement of sequencing technologies, long noncoding RNAs (lncRNAs) have gradually gained recognition and been proven to be closely associated with the occurrence and development of HCC [11,12]. Additionally, lncRNAs have been shown to play an important role in HBV-related HCC by interacting with HBV [13,14].…”

Section: Introductionmentioning

confidence: 99%

Transcriptome-Wide Dynamics of m7G-Related LncRNAs during the Progression from HBV Infection to Hepatocellular Carcinoma

Shi,

Zhu,

Sun

et al. 2023

Front. Biosci. (Landmark Ed)

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Background:The functional ramifications of internal N7-methylguanosine (m7G) modification on RNAs have recently come to light, yet its regulatory influence on long noncoding RNAs (lncRNAs) during the inflammatory-carcinogenesis transformation process in hepatitis B virus (HBV)-mediated hepatocellular carcinoma (HCC) remains largely unexplored. Methods: Clinical surgical samples encompassing HBV-related HCC, comprising both HCC tissue (tumor group, HBV+) and corresponding adjacent liver tissue (paracancerous group, HBV+), were collected for analysis. Additional adjacent normal liver tissues (normal group, HBV-) were acquired from patients with hepatic hemangioma, serving as controls. Employing MeRIP-seq, differential m7G levels of lncRNAs across these groups were compared to identify a subset of lncRNAs exhibiting continuous and dynamic changes in m7G modification. Subsequently, in vitro validation was conducted. Results: A total of 856 lncRNAs exhibited alterations in m7G modification when compared to paracancerous tissue and normal tissue. Similarly, 1775 lncRNAs displayed changes in m7G modification when comparing HCC tissue to paracancerous tissue. For intergroup comparison, orthogonal analysis revealed that 6 lncRNAs consistently demonstrated hyper-m7G modification.In vitro validation confirmed that among these 6 lncRNAs, TEKT4P2 and DNM1P41 exhibited m7G modification-dependent expression. Conclusions: This study provides a comprehensive analysis of lncRNA m7G modification during the inflammatory-carcinogenesis transformation process in HBV-mediated HCC. The findings highlight the potential for multiple lncRNAs to undergo m7G modification changes, with TEKT4P2 and DNM1P41 identified as promising molecular targets within this intricate regulatory landscape.

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CREB3 facilitates Donafenib resistance in hepatocellular carcinoma cells via the LSD1/CoREST/p65 axis by transcriptionally activating long noncoding RNA ZFAS1

Hou,

Xu,

Liu

2024

Translational Oncology

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Long noncoding RNAs as biomarkers for the diagnosis of hepatocellular carcinoma: A meta-analysis

Cited by 5 publications

References 39 publications

Differentially expressed non-coding RNAs and their regulatory networks in liver cancer

Differentially expressed non-coding RNAs and their regulatory networks in liver cancer

Transcriptome-Wide Dynamics of m7G-Related LncRNAs during the Progression from HBV Infection to Hepatocellular Carcinoma

CREB3 facilitates Donafenib resistance in hepatocellular carcinoma cells via the LSD1/CoREST/p65 axis by transcriptionally activating long noncoding RNA ZFAS1

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