Differentially expressed non-coding RNAs and their regulatory networks in liver cancer

Moldogazieva, Nurbubu T.; Zavadskiy, Sergey P.; Astakhov, Dmitry V.; Sologova, Susanna S.; Margaryan, Arus G.; Safrygina, Anastasiya A.; Smolyarchuk, Elena A.

doi:10.1016/j.heliyon.2023.e19223

Cited by 2 publications

(1 citation statement)

References 151 publications

(257 reference statements)

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“…An abundance of research has shown that lncRNAs participate in some biological processes of HCC, including proliferation, invasion, ferroptosis and metastasis, etc. ( 9 , 10 ). For instance, one study shows that HCC ferroptosis associative lncRNA (HEPFAL) is shown to mediate the ubiquitination of SLC7A11 to promote ferroptosis in HCC ( 11 ).…”

Section: Introductionmentioning

confidence: 99%

Suppression of hepatocellular carcinoma progression by long noncoding RNA apolipoprotein C1 pseudogene via the regulation of the microRNA-106b-PTEN axis

Qian,

Chen,

Chen

et al. 2023

Transl Cancer Res

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Background Numerous researches have reported that long noncoding RNAs (lncRNAs) participate in tumor development and progression. LncRNA apolipoprotein C-I pseudogene 1 ( APOC1P1 ), a pseudogene located in 19q13.2 between apolipoprotein C-I and apolipoprotein C-IV, is involved in a variety of diseases. However, the role of lncRNA APOC1P1 in hepatocellular carcinoma (HCC) remains unknown. Methods Quantitative polymerase chain reaction (qPCR) was performed to examine the expression of APOC1P1 , miR-106b, and PTEN (phosphatase and TENsin homolog deleted on chromosome 10) in HCC tissues, adjacent normal tissues, and specific cell lines (LO2, Bel-7407, HCCLM3, MHCC-97H, Hep G2, and Huh-7). Upregulation of APOC1P1 and downregulation of miR-106b were conducted via application of vector transfection and microRNA (miRNA) inhibitor. Bioinformatics analysis and luciferase reporter assay were used to verify the binding sites of APOC1P1 , miR-106b, and PTEN. Cell proliferation and invasion were determined with Cell Counting Kit-8 (CCK-8) and Transwell experiments. Subcellular location analysis was used to determine the distribution of APOC1P1 in cells, and Western blotting was used to detect the expression of PTEN. Results It was found that the expressions of APOC1P1 and PTEN were downregulated, while that of miR-106b was upregulated in HCC tissues and cells. Subcellular location analysis showed that APOC1P1 was localized in cytoplasm and competitively bound to miR-106b. APOC1P1 overexpression and miR-106b inhibition suppressed HCC cell proliferation and invasion. qPCR indicated the negative correlation between APOC1P1 expression and miR-106b expression in HCC tissues and a positive correlation between APOC1P1 and PTEN. Conclusions Our findings suggested that the lncRNA APOC1P1 inhibits HCC progression by competitively binding to miR-106b, leading to elevated PTEN expression, inhibiting cell proliferation and invasion in HCC cells. These results provide new insights into the diagnosis and therapy of HCC.

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Section: Introductionmentioning

confidence: 99%

Suppression of hepatocellular carcinoma progression by long noncoding RNA apolipoprotein C1 pseudogene via the regulation of the microRNA-106b-PTEN axis

Qian,

Chen,

Chen

et al. 2023

Transl Cancer Res

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Exploring the enigma: history, present, and future of long non-coding RNAs in cancer

Naseer,

Malik,

Zhang

et al. 2024

Discov Onc

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Long noncoding RNAs (lncRNAs), which are more than 200 nucleotides in length and do not encode proteins, play crucial roles in governing gene expression at both the transcriptional and posttranscriptional levels. These molecules demonstrate specific expression patterns in various tissues and developmental stages, suggesting their involvement in numerous developmental processes and diseases, notably cancer. Despite their widespread acknowledgment and the growing enthusiasm surrounding their potential as diagnostic and prognostic biomarkers, the precise mechanisms through which lncRNAs function remain inadequately understood. A few lncRNAs have been studied in depth, providing valuable insights into their biological activities and suggesting emerging functional themes and mechanistic models. However, the extent to which the mammalian genome is transcribed into functional noncoding transcripts is still a matter of debate. This review synthesizes our current understanding of lncRNA biogenesis, their genomic contexts, and their multifaceted roles in tumorigenesis, highlighting their potential in cancer-targeted therapy. By exploring historical perspectives alongside recent breakthroughs, we aim to illuminate the diverse roles of lncRNA and reflect on the broader implications of their study for understanding genome evolution and function, as well as for advancing clinical applications.

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Differentially expressed non-coding RNAs and their regulatory networks in liver cancer

Cited by 2 publications

References 151 publications

Suppression of hepatocellular carcinoma progression by long noncoding RNA apolipoprotein C1 pseudogene via the regulation of the microRNA-106b-PTEN axis

Suppression of hepatocellular carcinoma progression by long noncoding RNA apolipoprotein C1 pseudogene via the regulation of the microRNA-106b-PTEN axis

Exploring the enigma: history, present, and future of long non-coding RNAs in cancer

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