Long Noncoding RNA UCA1 Correlates With Electropathology in Patients With Atrial Fibrillation

Ramos, Kennedy Silva; Wijdeveld, Leonoor F.J.; Schie, Mathijs S. van; Taverne, Yannick J.H.J.; Boon, Reinier A.; Groot, Natasja M.S. de; Brundel, Bianca J. J. M.

doi:10.1016/j.jacep.2023.02.018

Cited by 4 publications

(4 citation statements)

References 37 publications

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“…One of its directs targets is NRF2, regulating cell viability and ROS levels. Sarrah levels were also decreased in the right atrial appendage of atrial fibrillation patients ( 198 ). However, serum levels of Sarrah were increased, suggesting disposal of Sarrah out of cells upon injury.…”

Section: Non-coding Rnas In Pathophysiological Processes Leading To H...mentioning

confidence: 99%

“…Furthermore, H19 overexpression was shown to alleviate hypertrophic response in isoprenaline-induced hypertrophy models by regulating SMAD4 via sponging miR-145-3p ( 103 ). Moreover, H19 knockout mice showed severe HF upon pressure overload and cardiomyocyte-targeted murine and human AAV9-mediated H19 therapy was able to improve cardiac function ( 198 ). LncRNA H19 is also involved in the development of cardiac fibrosis.…”

Section: Non-coding Rnas In Pathophysiological Processes Leading To H...mentioning

confidence: 99%

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Non-coding RNAs in the pathophysiology of heart failure with preserved ejection fraction

Jalink,

Schonk,

Boon

et al. 2024

Front. Cardiovasc. Med.

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Heart failure with preserved ejection fraction (HFpEF) is the largest unmet clinical need in cardiovascular medicine. Despite decades of research, the treatment option for HFpEF is still limited, indicating our ongoing incomplete understanding on the underlying molecular mechanisms. Non-coding RNAs, comprising of microRNAs (miRNAs), long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs), are non-protein coding RNA transcripts, which are implicated in various cardiovascular diseases. However, their role in the pathogenesis of HFpEF is unknown. Here, we discuss the role of miRNAs, lncRNAs and circRNAs that are involved in the pathophysiology of HFpEF, namely microvascular dysfunction, inflammation, diastolic dysfunction and cardiac fibrosis. We interrogated clinical evidence and dissected the molecular mechanisms of the ncRNAs by looking at the relevant in vivo and in vitro models that mimic the co-morbidities in patients with HFpEF. Finally, we discuss the potential of ncRNAs as biomarkers and potential novel therapeutic targets for future HFpEF treatment.

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Section: Non-coding Rnas In Pathophysiological Processes Leading To H...mentioning

confidence: 99%

Section: Non-coding Rnas In Pathophysiological Processes Leading To H...mentioning

confidence: 99%

Non-coding RNAs in the pathophysiology of heart failure with preserved ejection fraction

Jalink,

Schonk,

Boon

et al. 2024

Front. Cardiovasc. Med.

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“…Circulating lncRNA urothelial carcinoma-associated 1 (UCA1) may serve as a biomarker for acute myocardial infarction [ 93 , 94 ]. In addition, UCA1 was associated with electropathology in patients with atrial fibrillation [ 95 ]. Diao et al [ 77 ] studied the role of lncRNA UCA1 present in exosomes derived from human umbilical cord MSCs and found that UCA1 protects against H/R injury in cardiac microvascular endothelial cells using a rat model of I/R injury.…”

Section: The Role Of Msc-derived Lncrnas In Cardiac Injury and Repairmentioning

confidence: 99%

Mesenchymal Stem Cell-Derived Long Noncoding RNAs in Cardiac Injury and Repair

Tran,

Cruz,

Chan

et al. 2023

Cells

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Cardiac injury, such as myocardial infarction and heart failure, remains a significant global health burden. The limited regenerative capacity of the adult heart poses a challenge for restoring its function after injury. Mesenchymal stem cells (MSCs) have emerged as promising candidates for cardiac regeneration due to their ability to differentiate into various cell types and secrete bioactive molecules. In recent years, attention has been given to noncoding RNAs derived from MSCs, particularly long noncoding RNAs (lncRNAs), and their potential role in cardiac injury and repair. LncRNAs are RNA molecules that do not encode proteins but play critical roles in gene regulation and cellular responses including cardiac repair and regeneration. This review focused on MSC-derived lncRNAs and their implications in cardiac regeneration, including their effects on cardiac function, myocardial remodeling, cardiomyocyte injury, and angiogenesis. Understanding the molecular mechanisms of MSC-derived lncRNAs in cardiac injury and repair may contribute to the development of novel therapeutic strategies for treating cardiovascular diseases. However, further research is needed to fully elucidate the potential of MSC-derived lncRNAs and address the challenges in this field.

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“…Current patient-cohort studies analyze RNA that is extracted from whole atrial tissue. Left and right atrial appendage tissues are appropriate for studying the electropathology of AF, as both structural remodeling and electrical conduction disorders can be observed in these tissues in the context of AF [ 1 , 78 , 79 ]. However, a drawback of sequencing bulk RNA from the atrial tissue is that the observed changes in gene expression mostly embody large scale shifts, instead of specific mechanisms in individual cell types.…”

Section: Challenges and Perspectives In Rna Sequencing Technologiesmentioning

confidence: 99%

Dissecting the Molecular Mechanisms Driving Electropathology in Atrial Fibrillation: Deployment of RNA Sequencing and Transcriptomic Analyses

Huiskes,

Creemers,

Brundel

2023

Cells

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Despite many efforts to treat atrial fibrillation (AF), the most common progressive and age-related cardiac tachyarrhythmia in the Western world, the efficacy is still suboptimal. A plausible reason for this is that current treatments are not directed at underlying molecular root causes that drive electrical conduction disorders and AF (i.e., electropathology). Insights into AF-induced transcriptomic alterations may aid in a deeper understanding of electropathology. Specifically, RNA sequencing (RNA-seq) facilitates transcriptomic analyses and discovery of differences in gene expression profiles between patient groups. In the last decade, various RNA-seq studies have been conducted in atrial tissue samples of patients with AF versus controls in sinus rhythm. Identified differentially expressed molecular pathways so far include pathways related to mechanotransduction, ECM remodeling, ion channel signaling, and structural tissue organization through developmental and inflammatory signaling pathways. In this review, we provide an overview of the available human AF RNA-seq studies and highlight the molecular pathways identified. Additionally, a comparison is made between human RNA-seq findings with findings from experimental AF model systems and we discuss contrasting findings. Finally, we elaborate on new exciting RNA-seq approaches, including single-nucleotide variants, spatial transcriptomics and profiling of different populations of total RNA, small RNA and long non-coding RNA.

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Long Noncoding RNA UCA1 Correlates With Electropathology in Patients With Atrial Fibrillation

Cited by 4 publications

References 37 publications

Non-coding RNAs in the pathophysiology of heart failure with preserved ejection fraction

Non-coding RNAs in the pathophysiology of heart failure with preserved ejection fraction

Mesenchymal Stem Cell-Derived Long Noncoding RNAs in Cardiac Injury and Repair

Dissecting the Molecular Mechanisms Driving Electropathology in Atrial Fibrillation: Deployment of RNA Sequencing and Transcriptomic Analyses

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