Mesenchymal Stem Cell-Derived Long Noncoding RNAs in Cardiac Injury and Repair

Abstract

Cardiac injury, such as myocardial infarction and heart failure, remains a significant global health burden. The limited regenerative capacity of the adult heart poses a challenge for restoring its function after injury. Mesenchymal stem cells (MSCs) have emerged as promising candidates for cardiac regeneration due to their ability to differentiate into various cell types and secrete bioactive molecules. In recent years, attention has been given to noncoding RNAs derived from MSCs, particularly long noncoding RNAs (lncRNAs), and their potential role in cardiac injury and repair. LncRNAs are RNA molecules that do not encode proteins but play critical roles in gene regulation and cellular responses including cardiac repair and regeneration. This review focused on MSC-derived lncRNAs and their implications in cardiac regeneration, including their effects on cardiac function, myocardial remodeling, cardiomyocyte injury, and angiogenesis. Understanding the molecular mechanisms of MSC-derived lncRNAs in cardiac injury and repair may contribute to the development of novel therapeutic strategies for treating cardiovascular diseases. However, further research is needed to fully elucidate the potential of MSC-derived lncRNAs and address the challenges in this field.

Intracranial aneurysm circulating exosome-derived LncRNA ATP1A1-AS1 promotes smooth muscle cells phenotype switching and apoptosis

“…Exosomal LncRNAs play a crucial role in the pathomechanisms of cancers, cardiovascular diseases and central nervous diseases; however, their expression and functional implications in IAs remain unexplored [23][24][25][26][27]. In this study, we applied next-generation sequencing (NGS) to profile the differentially expressed LncRNAs in circulating exosomes from IA patients, subsequently confirming these findings through quantitative real-time polymerase chain reaction (qRT-PCR).…”

Emerging Strategies in Mesenchymal Stem Cell-Based Cardiovascular Therapeutics

“…Genetic modifications of MSCs for targeted repair are performed using both viral vectors and non-viral methods, enhancing specificity and efficacy in regenerative treatments. The ease of isolation and expansion of MSCs in vitro makes them suitable candidates for transfection and targeted recruitment at inflammation sites [178][179][180].…”