Long noncoding RNA TSPOAP1 antisense RNA 1 negatively modulates type I IFN signaling to facilitate influenza A virus replication

Wang, Qi; Zhang, Daining; Feng, Wenjing; Guo, Yidi; Sun, Xiaochuan; Zhang, Maolin; Zhang, Guan; Duan, Ming

doi:10.1002/jmv.25483

Cited by 29 publications

(29 citation statements)

References 34 publications

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“…The ceRNA network indicates that lncRNA may contain bladder cancer-related microRNA (miRNA) recognition elements [ 36 ]. The expression of host lncRNA TSPOAP1-AS1 was significantly induced by influenza A virus (IAV) infection [ 37 ]. Giulietti et al performed a survival analysis and identified TSPOAP1-AS1 as prognostic biomarkers for pancreatic cancer [ 38 ].…”

Section: Discussionmentioning

confidence: 99%

Identification and Validation of a Potential Prognostic 7-lncRNA Signature for Predicting Survival in Patients with Multiple Myeloma

Zhong

Liu

et al. 2020

BioMed Research International

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Background. An increasing number of studies have indicated that the abnormal expression of certain long noncoding RNAs (lncRNAs) is linked to the overall survival (OS) of patients with myeloma. Methods. Gene expression data of myeloma patients were downloaded from the Gene Expression Omnibus (GEO) database (GSE4581 and GSE57317). Cox regression analysis, Kaplan-Meier, and receiver operating characteristic (ROC) analysis were performed to construct and validate the prediction model. Single sample gene set enrichment (ssGSEA) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis were used to predict the function of a specified lncRNA. Results. In this study, a seven-lncRNA signature was identified and used to construct a risk score system for myeloma prognosis. This system was used to stratify patients with different survival rates in the training set into high-risk and low-risk groups. Test set, the entire test set, the external validation set, and the myeloma subtype achieved the authentication of the results. In addition, functional enrichment analysis indicated that 7 prognostic lncRNAs may be involved in the tumorigenesis of myeloma through cancer-related pathways and biological processes. The results of the immune score showed that IF_I was negatively correlated with the risk score. Compared with the published gene signature, the 7-lncRNA model has a higher C-index (above 0.8). Conclusion. In summary, our data provide evidence that seven lncRNAs could be used as independent biomarkers to predict the prognosis of myeloma, which also indicated that these 7 lncRNAs may be involved in the progression of myeloma.

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Section: Discussionmentioning

confidence: 99%

Identification and Validation of a Potential Prognostic 7-lncRNA Signature for Predicting Survival in Patients with Multiple Myeloma

Zhong

Liu

et al. 2020

BioMed Research International

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“…As a general rule, lncRNAs whose expression is altered by the antiviral pathways should show deregulation in response to infection with several other viruses, and/or in response to treatment with IFN and/or different PAMPs. This is the case of lncRNA TSPOAP1-AS1 (TSPOAP1 antisense RNA 1) and MIR155HG (miRNA-155 host gene), upregulated in response to infection with influenza and other viruses and by the dsRNA mimic pI:C (lncRNA TSPOAP1-AS1) [85,86]. Interestingly, lncRNA TSPOAP1-AS1 inhibits IFNβ and ISG transcription, playing a proviral role, whereas MIR155HG functions as an antiviral by inhibiting PTP1B (protein tyrosine phosphatase 1B), resulting in higher production of IFNβ and several ISGs.…”

Section: Lncrnas That Affect the Antiviral Responsementioning

confidence: 99%

LncRNAs in HCV Infection and HCV-Related Liver Disease

Unfried¹,

Fortes²

2020

IJMS

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Long non-coding RNAs (lncRNAs) are transcripts with poor coding capacity that may interact with proteins, DNA, or other RNAs to perform structural and regulatory functions. The lncRNA transcriptome changes significantly in most diseases, including cancer and viral infections. In this review, we summarize the functional implications of lncRNA-deregulation after infection with hepatitis C virus (HCV). HCV leads to chronic infection in many patients that may progress to liver cirrhosis and hepatocellular carcinoma (HCC). Most lncRNAs deregulated in infected cells that have been described function to potentiate or block the antiviral response and, therefore, they have a great impact on HCV viral replication. In addition, several lncRNAs upregulated by the infection contribute to viral release. Finally, many lncRNAs have been described as deregulated in HCV-related HCC that function to enhance cell survival, proliferation, and tumor progression by different mechanisms. Interestingly, some HCV-related HCC lncRNAs can be detected in bodily fluids, and there is great hope that they could be used as biomarkers to predict cancer initiation, progression, tumor burden, response to treatment, resistance to therapy, or tumor recurrence. Finally, there is high confidence that lncRNAs could also be used to improve the suboptimal long-term outcomes of current HCC treatment options.

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“…In support of the positive role of NRAV in influenza virus replication, ectopic expression of human NRAV in mice renders them more susceptible to IAV infection, including faster body weight loss, lower survival, and higher lung viral titre in NRAV transgenic mice compared with wild-type littermates [ 46 ]. Another lncRNA TSPOAP1-AS1 is upregulated by IAV infection in a dose- and time-dependent manner [ 47 ]. TSPOAP1-AS1 promotes IAV replication by suppressing IAV-induced IFNb1 transcription, interferon-sensitive response element (ISRE) activation, and downstream ISGs expression [ 47 ].…”

Section: Roles Of Lncrnas In Influenza Virus Infectionmentioning

confidence: 99%

“…Another lncRNA TSPOAP1-AS1 is upregulated by IAV infection in a dose- and time-dependent manner [ 47 ]. TSPOAP1-AS1 promotes IAV replication by suppressing IAV-induced IFNb1 transcription, interferon-sensitive response element (ISRE) activation, and downstream ISGs expression [ 47 ]. lnc-MxA facilitates the replication of IAV by forming an RNA–DNA triplex with the IFN-β promoter, interfering with the enrichment of IRF3 and p65 at the IFN-β promoter and thus negatively regulating the transcription of IFN-β.…”

Section: Roles Of Lncrnas In Influenza Virus Infectionmentioning

confidence: 99%

Roles of lncRNAs in influenza virus infection

Wang

Cen

2020

Emerging Microbes & Infections

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Recent studies have identified host long noncoding RNAs (lncRNAs) as key regulators of host-virus interactions during viral infection. The influenza A virus (IAV) remains a serious threat to public health and economic stability. It is well known that thousands of lncRNAs are differentially expressed upon IAV infection, some of which regulate IAV infection by modulating the host innate immune response, affecting cellular metabolism, or directly interacting with viral proteins. Some of these lncRNAs appear to be required for IAV infection, but the molecular mechanisms are not completely elucidated. In this review, we summarize the roles of host lncRNAs in regulating IAV infection and provide an overview of the lncRNA-mediated regulatory network. The goal of this review is to stimulate further research on the function of both well-established and newly discovered lncRNAs in IAV infection.

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Long noncoding RNA TSPOAP1 antisense RNA 1 negatively modulates type I IFN signaling to facilitate influenza A virus replication

Cited by 29 publications

References 34 publications

Identification and Validation of a Potential Prognostic 7-lncRNA Signature for Predicting Survival in Patients with Multiple Myeloma

Identification and Validation of a Potential Prognostic 7-lncRNA Signature for Predicting Survival in Patients with Multiple Myeloma

LncRNAs in HCV Infection and HCV-Related Liver Disease

Roles of lncRNAs in influenza virus infection

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