Roles of lncRNAs in influenza virus infection

Wang, Jing; Cen, Shan

doi:10.1080/22221751.2020.1778429

Cited by 29 publications

(23 citation statements)

References 76 publications

(94 reference statements)

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“…Although great progress has been made in the diagnosis and treatment for HCC, these achievements were far from improving the survival time and cure rate of HCC patients. More and more studies had shown that lncRNAs play an important role in various biological processes of human body (Wang et al 2020;Qu et al 2020;Lu et al 2020). In order to understand the development, diagnosis and treatment of the disease we need to explore the regulation mode of human gene deeply and immediately.…”

Section: Discussionmentioning

confidence: 99%

WITHDRAWN: A Novel Long Non-coding RNA, ENSG00000236199, Inhibits Proliferation and Metastasis through NRIP1 by Sponging miR-576-5p in Hepatocellular Carcinoma

Cui

Lin

Zhao

et al. 2020

Preprint

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Background: Hepatocellular carcinoma (HCC) is a common malignancy of the digestive system. A novel long non-coding RNA, ENSG00000236199 (lncRNA-199) , whose role in tumors has not been reported, especially in HCC. Methods: The expression of lncRNA-199 and miR-576-5p were detected by Real-time quantitative polymerase chain reaction (RT-qPCR), NRIP1 was measured by Western blotting. HCC cell proliferation and metastasis of HCC were examined using functional tests. Luciferase reporter assay was performed to confirm the relationship between lncRNA-199 and miR-576-5p, between miR-576-5p and NRIP1. Results: LncRNA-199 was frequently down-regulated in HCC and this down-regulation was negatively correlated with prognosis. Overexpression of lncRNA-199 could inhibit the growth and metastasis of HCC, while knockdown lncRNA-199 had the opposite effect. Down-regulated lncRNA-199 also could induce epithelial-mesenchymal transformation (EMT). Luciferase reporter assay demonstrated lncRNA-199 could modulate NRIP1 by sponge miR-576-5p. Conclusion: LncRNA-199 inhibited growth and metastasis through miR-576-5p/NRIP1 axis in HCC. This study revealed a novel unknown lncRNA function in malignant tumors, especially in HCC. At the same time, the regulatory mechanism of lncRNA-199 in HCC was clarified.

show abstract

Section: Discussionmentioning

confidence: 99%

WITHDRAWN: A Novel Long Non-coding RNA, ENSG00000236199, Inhibits Proliferation and Metastasis through NRIP1 by Sponging miR-576-5p in Hepatocellular Carcinoma

Cui

Lin

Zhao

et al. 2020

Preprint

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“…Deregulation of lncRNA has been observed in many infectious diseases, especially in diseases caused by viral infection and reviewed [ 18 ]. Infections with influenza virus (IAV), HIV, herpes simplex virus (HSV), hepatitis C virus (HCV), hepatitis B virus (HBV), severe acute respiratory syndrome coronavirus (SARS-CoV) and others alter the expression of host lncRNA 19 , 20 . Expression of lncRNA EGOT, NEAT1, BISPR/LncBST2, LINC01191/VIN/lnc-ACTR3, ISR (IFN-stimulated lncRNA) 2 and ISR8, LOC100506319/LINC01988/LncRNA-PAAN, LOC102637961/lncRNA-ACOD1, MIR155HG, TSPOAP1-AS1, PSMB8-AS1, PSORS1C3, IVRPIE was increased and expression of NRAV/DYNLL1AS1 was decreased in IAV infected cells 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 .…”

Section: Introductionmentioning

confidence: 99%

In silico analysis of altered expression of long non-coding RNA in SARS-CoV-2 infected cells and their possible regulation by STAT1, STAT3 and interferon regulatory factors

Laha

Saha

Dutta

et al. 2021

Heliyon

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Altered expression of long noncoding RNA (lncRNA), longer than 200 nucleotides without potential for coding protein, has been observed in diverse human diseases including viral diseases. It is largely unknown whether lncRNA would deregulate in SARS-CoV-2 infection, causing ongoing pandemic COVID-19. To identify, if lncRNA was deregulated in SARS-CoV-2 infected cells, we analyzed in silico the data in GSE147507. It was revealed that expression of 20 lncRNA like MALAT1, NEAT1 was increased and 4 lncRNA like PART1, TP53TG1 was decreased in at least two independent cell lines infected with SARS-CoV-2. Expression of NEAT1 was also increased in lungs tissue of COVID-19 patients. The deregulated lncRNA could interact with more than 2800 genes/proteins and 422 microRNAs as revealed from the database that catalogs experimentally determined interactions. Analysis with the interacting gene/protein partners of deregulated lncRNAs revealed that these genes/proteins were associated with many pathways related to viral infection, inflammation and immune functions. To find out whether these lncRNAs could be regulated by STATs and interferon regulatory factors (IRFs), we used ChIPBase v2.0 that catalogs experimentally determined binding from ChIP-seq data. It was revealed that any one of the transcription factors IRF1, IRF4, STAT1, STAT3 and STAT5A had experimentally determined binding at regions within -5kb to +1kb of the deregulated lncRNAs in at least 2 independent cell lines/conditions. Our analysis revealed that several lncRNAs could be regulated by IRF1, IRF4 STAT1 and STAT3 in response to SARS-CoV-2 infection and lncRNAs might be involved in antiviral response. However, these in silico observations are necessary to be validated experimentally.

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“…The known and the unknown lncRNA expression in EBOV, LPS and RESTV cells identi ed. Cellular lncRNAs which actively expressed during viral infections may help to promote the virus replications, suppress the antiviral immune response [34]. In total, 1581 known and 405 novel lncRNA identi ed.…”

Section: Discussionmentioning

confidence: 99%

The Systematic Analysis of lncRNA Expression in Ebola-infected Human Macrophages

Naorem

Sinnarasan

Paul

et al. 2021

Preprint

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Ebola is a dangerous virus which causes severe headache, muscle pain, hemorrhagic fever, and multi-organ failure. The underlying mechanism of Ebola-human interaction at the molecular level remains unexplored. The recently reported research revealed that lncRNA are known to be important in the pathogenesis of viruses. The study carried out the comprehensive analysis of lncRNA identification in EBOLA, LPS and RESTV infected MDMs. In EBOLA, the total number of known lncRNA is EBOLA 555 in, in RESTV 476, in LPS 550 and the novel lncRNAs in EBOLA 142, RESTV 127, in LPS 136 identified. Also, differentially expressed lncRNAs and neighbourhood genes of each lncRNA about 100kb identified for analysis.The study reported the known and novel lncRNA in EBOLA, LPS and RESTV infected cells of MDMs. The results of the study may help to understand the immune response further.

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Roles of lncRNAs in influenza virus infection

Cited by 29 publications

References 76 publications

WITHDRAWN: A Novel Long Non-coding RNA, ENSG00000236199, Inhibits Proliferation and Metastasis through NRIP1 by Sponging miR-576-5p in Hepatocellular Carcinoma

WITHDRAWN: A Novel Long Non-coding RNA, ENSG00000236199, Inhibits Proliferation and Metastasis through NRIP1 by Sponging miR-576-5p in Hepatocellular Carcinoma

In silico analysis of altered expression of long non-coding RNA in SARS-CoV-2 infected cells and their possible regulation by STAT1, STAT3 and interferon regulatory factors

The Systematic Analysis of lncRNA Expression in Ebola-infected Human Macrophages

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