Long noncoding RNA &lt;em&gt;SPRY4-IT1&lt;/em&gt; promotes malignant development of colorectal cancer by targeting epithelial&amp;ndash;mesenchymal transition

Dong, Chen; Ding, Qiong; Wu, Yu; Gao, Ming; Wang, Yilian

doi:10.2147/ott.s111794

Cited by 43 publications

(31 citation statements)

References 23 publications

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“…Among these four prognostic lncRNAs, SPRY4-IT1 has been widely reported in many cancer types [ 21 , 25 ], whereas none of the other three lncRNAs have been reported to be associated with human cancers. So, we attempt to further examine the expression pattern of SPRY4-IT1 in LUAD patients.…”

Section: Resultsmentioning

confidence: 99%

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Up-regulation of long non-coding RNA SPRY4-IT1 promotes tumor cell migration and invasion in lung adenocarcinoma

Zhang

Chi²,

Zhao

2017

Oncotarget

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Long non-coding RNAs (lncRNAs) play important role in a variety of biological processes, and are tightly associated with tumorigenesis and cancer prognosis. However, the potential power of lncRNA signatures in predicting survival of patients with lung adenocarcinoma (LUAD) has not been investigated. Here, we identified a four-lncRNA signature (SPRY4-IT1, LINC00941,GPR158-AS1 and KCNK15-AS1) displaying prognostic values for LUAD using The Cancer Genome Atlas (TCGA) dataset. Based on the four-lncRNA signature, the LUAD patients can be classified into high-risk and low-risk groups with significantly different survival. We further validated the expression of SPRY4-IT1 in LUAD tissues and corresponding normal lung tissues using quantitative real-time PCR in Chinese LUAD patients. The results showed that SPRY4-IT1 was significantly up-regulated in LUAD tissues. Further analysis indicated that LUAD patients with high SPRY4-IT1 expression have significantly poorer overall survival in Chinese LUAD patients. Moreover, knock-down of SPRY4-IT1 can inhibit the lung cancer cell migration and invasion. The present work indicated that SPRY4-IT1 may play a pivotal role in promoting tumor migration and invasion in LUAD. Our work implicates the promising effect of SPRY4-IT1 on the prognosis of LUAD.

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Section: Resultsmentioning

confidence: 99%

“…A four-lncRNA signature displayed prognostic values for LUAD. Notably, SPRY4-IT1 has been reported to be desregulated in several human cancers [ 11 , 21 , 22 ], such as hepatocellular carcinoma [ 23 ] and melanoma [ 24 ]. However, the underlying molecular mechanism of SPRY4-IT1 remains unclear in LUAD.…”

Section: Introductionmentioning

confidence: 99%

Up-regulation of long non-coding RNA SPRY4-IT1 promotes tumor cell migration and invasion in lung adenocarcinoma

Zhang

Chi²,

Zhao

2017

Oncotarget

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“…Among the eligible articles, 31 were from China, 3 from Japan and 1 from Czech Republic. In the including 34 studies, 29 articles analyzed the relationship between the expression of lncRNAs and gender[16–20, 24–29, 31, 32, 34–37, 39–46, 48–51], 7 studies estimated the association between lncRNAs and tumor size[19, 24, 25, 27, 41, 42, 48], 16 studies estimated the association between lncRNAs and tumor differentiation[16, 17, 19, 24, 25, 28, 29, 34, 36, 37, 39, 40, 43, 45, 46, 48], 24 studies were about lymph node metastasis(LNM)[16–20, 26, 27, 29–32, 34–37, 39, 40, 42–46, 48, 50], and 20 were about distant metastasis[16, 18–20, 25, 27–29, 35–37, 39, 40, 42–46, 48, 50], 18 studies demonstrated that lncRNAs were correlated with TNM stage[…”

Section: Resultsmentioning

confidence: 99%

The prognostic value of abnormally expressed lncRNAs in colorectal cancer: A meta-analysis

Wang

et al. 2017

PLoS ONE

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BackgroundColorectal cancer (CRC) is the third most prevalent cancer type and the third leading cause of cancer-related deaths worldwide, it is urgently needed to discover a new marker for the progress of CRC. Many long noncoding RNAs (lncRNAs) have been reported to be abnormally expressed in CRC, and may be feasible as effective biomarkers and prognostic factors. The aim of this study was to identify the prognostic value of various lncRNAs in CRC.MethodsPubmed, Web of Science, Embase and Cochrane Library were searched for potentially related studies. A total of 34 eligible studies including 30 on overall survival (OS), 7 on disease-free survival (DFS), 1 on relapse-free survival (RFS), 2 on disease-specific survival (DSS) and 29 on clinicopathological features were qualified from the databases.ResultsThe results showed that the expression levels of lncRNAs were significantly associated with poor OS (hazard ratio (HR) = 2.08, 95% confidence interval (CI) = 1.68–2.57, P<0.001, I2 = 70%), DFS (HR = 1.79, 95% CI = 1.54–2.08, P<0.001, I2 = 6%) and DSS (HR = 0.11, 95% CI = 0.02–0.54, P = 0.007, I2 = 14%). Subgroup analysis further showed that lncRNA transcription level was significantly associated with tumor differentiation (odds ratio (OR) = 0.51, 95% CI = 0.34–0.77, P = 0.001), lymph node metastasis (OR = 1.63, 95% CI = 1.23–2.17, P = 0.0007), distant metastasis (OR = 2.06, 95% CI = 1.29–3.30, P = 0.002), TNM stage (OR = 0.44, 95% CI = 0.32–0.62, P<0.001), tumor invasion depth (OR = 0.48, 95% CI = 0.39–0.60, P<0.001).ConclusionsThe meta-analysis demonstrated that abnormal lncRNA transcription level may serve as a promising indicator for prognostic of patients with CRC.

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“…Knockdown of lncRNA SPRY4-IT1 inhibited the migration and invasion of colorectal cancer cells and induced cell cycle arrest 19. The lncRNA FTX could inhibit HCC cell growth and metastasis both in vitro and in vivo 20.…”

Section: Discussionmentioning

confidence: 99%

Long non-coding RNA CCAT2 is associated with poor prognosis in hepatocellular carcinoma and promotes tumor metastasis by regulating Snail2-mediated epithelial–mesenchymal transition

Xu¹,

Wang²,

Zhang³

et al. 2017

OTT

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Increasing evidence has demonstrated that aberrant expressions of long non-coding RNAs (lncRNAs) are involved in various malignancies, including hepatocellular carcinoma (HCC). This study aimed to investigate the role of lncRNA colon cancer-associated transcript 2 (CCAT2) in the progression of HCC. Quantitative real-time polymerase chain reaction analysis confirmed that CCAT2 was upregulated in HCC cell lines and cancerous tissues compared with normal liver cell line and adjacent normal tissue samples. The level of CCAT2 was positively associated with tumor–node–metastasis stages and vessel invasion. Survival analyses revealed that high CCAT2 expression predicted poor prognostic outcomes, serving as an independent prognostic factor for HCC patients. Patients with high CCAT2 expression had a 1.849-fold increased risk of death compared with those with low CCAT2 expression. Moreover, we also found that knockdown of CCAT2 expression reduced cell migration and invasion in vitro. We further demonstrated that CCAT2 played a key role in enhancing the epithelial–mesenchymal transition (EMT) through the regulation of vimentin, E-cadherin and transcription factor snail2 expression. Taken together, our findings showed that high CCAT2 expression is associated with poor survival in HCC patients. CCAT2 promotes HCC progression by regulating Snail2-induced EMT. CCAT2 may be a prognostic biomarker and therapeutic target for HCC.

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Long noncoding RNA <em>SPRY4-IT1</em> promotes malignant development of colorectal cancer by targeting epithelial–mesenchymal transition

Cited by 43 publications

References 23 publications

Up-regulation of long non-coding RNA SPRY4-IT1 promotes tumor cell migration and invasion in lung adenocarcinoma

Up-regulation of long non-coding RNA SPRY4-IT1 promotes tumor cell migration and invasion in lung adenocarcinoma

The prognostic value of abnormally expressed lncRNAs in colorectal cancer: A meta-analysis

Long non-coding RNA CCAT2 is associated with poor prognosis in hepatocellular carcinoma and promotes tumor metastasis by regulating Snail2-mediated epithelial–mesenchymal transition

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Long noncoding RNA <em>SPRY4-IT1</em> promotes malignant development of colorectal cancer by targeting epithelial&ndash;mesenchymal transition

Cited by 43 publications

References 23 publications

Up-regulation of long non-coding RNA SPRY4-IT1 promotes tumor cell migration and invasion in lung adenocarcinoma

Up-regulation of long non-coding RNA SPRY4-IT1 promotes tumor cell migration and invasion in lung adenocarcinoma

The prognostic value of abnormally expressed lncRNAs in colorectal cancer: A meta-analysis

Long non-coding RNA CCAT2 is associated with poor prognosis in hepatocellular carcinoma and promotes tumor metastasis by regulating Snail2-mediated epithelial&ndash;mesenchymal transition

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Long noncoding RNA <em>SPRY4-IT1</em> promotes malignant development of colorectal cancer by targeting epithelial–mesenchymal transition

Long non-coding RNA CCAT2 is associated with poor prognosis in hepatocellular carcinoma and promotes tumor metastasis by regulating Snail2-mediated epithelial–mesenchymal transition