Long Noncoding RNA DLX6-AS1 Regulates the Growth and Aggressiveness of Colorectal Cancer Cells Via Mediating the miR-26a/EZH2 Axis

Kong, Weiqi; Liang, Jianjing; Du, Jing; Ye, Zhen-Xiong; Gao, Peng; Liang, Yulong

doi:10.1089/cbr.2020.3589

Cited by 13 publications

(16 citation statements)

References 31 publications

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“…26 LncRNAs and miRNAs are elaborated to Also, increased DLX6-AS1 is presented in colorectal cancer tissues and depleting DLX6-AS1 restricts metastasis of colorectal cancer cells and arrests cell phase progression. 28 Besides, oesophageal squamous cell carcinoma specimens express elevated DLX6-AS1 and DLX6-AS1 down-regulation is attributed to depressed cell proliferation and metastasis. 29 Crucially, the network between DLX6-AS1 and its regulatory gene miR-193b-3p has been deciphered and the results imply that DLX6-AS1 is negatively connected with and targeted to miR-193b-3p.…”

Section: Discussionmentioning

confidence: 99%

“… 27 Also, increased DLX6‐AS1 is presented in colorectal cancer tissues and depleting DLX6‐AS1 restricts metastasis of colorectal cancer cells and arrests cell phase progression. 28 Besides, oesophageal squamous cell carcinoma specimens express elevated DLX6‐AS1 and DLX6‐AS1 down‐regulation is attributed to depressed cell proliferation and metastasis. 29…”

Section: Discussionmentioning

confidence: 99%

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Silencing long non‐coding RNA DLX6‐AS1 or restoring microRNA‐193b‐3p enhances thyroid carcinoma cell autophagy and apoptosis via depressing HOXA1

Wang

et al. 2021

J Cellular Molecular Medi

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Thyroid carcinoma (TC), as the most prevalent endocrine malignancy, is mainly originated from thyroid follicular epithelial cells, encouraging the rise of papillary, follicular and poorly differentiated or anaplastic entities whereas about 5% TC from parathyroid follicular thyroid cells. 1 Anaplastic thyroid carcinoma (ATC) is rare but extremely aggressive with a high mortality rate while differentiated TC is relatively common and indolent. 2 Various therapies such as surgery, radiotherapy and chemotherapy have been implied in the use of TC, but with limitations in drug resistance, postoperative complications and side effects or unmet efficacy. 3 Facing to the obstacles in treating TC, the requirement for therapeutic agents targeting TC positions a priority.The co-expression network of long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) has been extensively discussed in TC.Exactly, it is recorded that miR-146b-5p negatively regulates lncRNA MALAT1 to function in papillary TC (PTC) cell invasion and proliferation. 4 Also, by co-working with miR-206 and miR-599, lncRNA

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Silencing long non‐coding RNA DLX6‐AS1 or restoring microRNA‐193b‐3p enhances thyroid carcinoma cell autophagy and apoptosis via depressing HOXA1

Wang

et al. 2021

J Cellular Molecular Medi

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“…(Ref. 36) showed that CRC patients at advanced stage or with lymphatic metastasis had higher DLX6-AS1 expression (Ref. 36).…”

Section: The Effect Of Dlx6-as1 On Digestive System Cancersmentioning

confidence: 99%

“…36) showed that CRC patients at advanced stage or with lymphatic metastasis had higher DLX6-AS1 expression (Ref. 36). One of the mechanisms was the regulation of the growth and aggressiveness of CRC cells via mediating miR-26a and a significant negative correlation between DLX6-AS1 and miR-26a was observed (Ref.…”

Section: The Effect Of Dlx6-as1 On Digestive System Cancersmentioning

confidence: 99%

“…One of the mechanisms was the regulation of the growth and aggressiveness of CRC cells via mediating miR-26a and a significant negative correlation between DLX6-AS1 and miR-26a was observed (Ref. 36). It was found that, miR-26a is a tumour suppressor gene, and can inhibit the malignant biological features of CRC cells (Ref.…”

Section: The Effect Of Dlx6-as1 On Digestive System Cancersmentioning

confidence: 99%

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DLX6-AS1: a putative lncRNA candidate in multiple human cancers

Sheykhhasan

Ahmadyousefi

Seyedebrahimi

et al. 2021

Expert Rev. Mol. Med.

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Long non-coding RNAs (lncRNAs) have important roles in regulating the expression of genes and act as biomarkers in the initial development of different cancers. Increasing research studies have verified that dysregulation of lncRNAs occurs in various pathological processes including tumorigenesis and cancer progression. Among the different lncRNAs, DLX6-AS1 has been reported to act as an oncogene in the development and prognoses of different cancers, by affecting many different signalling pathways. This review summarises and analyses the recent research studies describing the biological functions of DLX6-AS1, its overall effect on signalling pathways and the molecular mechanisms underlying its action on the expression of genes in multiple human cancers. Our critical analysis suggests that different signalling pathways associated to this lncRNA may be used as a biomarker for diagnosis, or targets of treatment in cancers.

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The role of epigenetic modifications in Colorectal Cancer Metastasis

Liang

et al. 2022

Clin Exp Metastasis

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Distant metastasis is the major contributor to the high mortality rate of colorectal cancer (CRC). To overcome the poor prognosis caused by distant metastasis, the mechanisms of CRC metastasis should be further explored. Epigenetic events are the main mediators of gene regulation and further affect tumor progression. Recent studies have found that some epigenetic enzymes are often dysregulated or mutated in multiple tumor types, which prompted us to study the roles of these enzymes in CRC metastasis. In this review, we summarized the alteration of enzymes related to various modifications, including histone modification, nonhistone modification, DNA methylation, and RNA methylation, and their epigenetic mechanisms during the progression of CRC metastasis. Existing data suggest that targeting epigenetic enzymes is a promising strategy for the treatment of CRC metastasis.

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Long Noncoding RNA DLX6-AS1 Regulates the Growth and Aggressiveness of Colorectal Cancer Cells Via Mediating the miR-26a/EZH2 Axis

Cited by 13 publications

References 31 publications

Silencing long non‐coding RNA DLX6‐AS1 or restoring microRNA‐193b‐3p enhances thyroid carcinoma cell autophagy and apoptosis via depressing HOXA1

Silencing long non‐coding RNA DLX6‐AS1 or restoring microRNA‐193b‐3p enhances thyroid carcinoma cell autophagy and apoptosis via depressing HOXA1

DLX6-AS1: a putative lncRNA candidate in multiple human cancers

The role of epigenetic modifications in Colorectal Cancer Metastasis

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