DLX6-AS1: a putative lncRNA candidate in multiple human cancers

Sheykhhasan, Mohsen; Ahmadyousefi, Yaghoub; Seyedebrahimi, Reihaneh; Tanzadehpanah, Hamid; Manoochehri, Hamed; Dama, Paola; Hosseini, Nashmin Fayazi; Akbari, Mohammad Reza; Farsani, Mohsen Eslami

doi:10.1017/erm.2021.17

Cited by 17 publications

(9 citation statements)

References 78 publications

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“…Apoptosis, invasion, and metastasis have all been linked to the activity of miRNAs ( Noda 2012 ) ( Si et al, 2019 ). However, upregulation of miR-21 and lncRNA (long non-coding RNA) has been linked to various cancers, such as malignant B-cell lymphoma and breast cancer ( Feng and Tsao, 2016 ; Chi et al, 2019 ; Zhao et al, 2021 ; Sheykhhasan et al, 2021 ). Let-7 miRNA, on the other hand, is known as the “keeper of differentiation” and has been discovered as possible cancer and immune response therapeutic agent ( Gilles and Slack, 2018 ; Chirshev et al, 2019 ).…”

Section: Discussionmentioning

confidence: 99%

Tris(2-Pyridylmethylamine)V(O)2 Complexes as Counter Ions of Diprotonated Decavanadate Anion: Potential Antineoplastic Activity

et al. 2022

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The synthesis and theoretical-experimental characterization of a novel diprotanated decavanadate is presented here due to our search for novel anticancer metallodrugs. Tris(2-pyridylmethyl)amine (TPMA), which is also known to have anticancer activity in osteosarcoma cell lines, was introduced as a possible cationic species that could act as a counterpart for the decavanadate anion. However, the isolated compound contains the previously reported vanadium (V) dioxido-tpma moieties, and the decavanadate anion appears to be diprotonated. The structural characterization of the compound was performed by infrared spectroscopy and single-crystal X-ray diffraction. In addition, DFT calculations were used to analyze the reactive sites involved in the donor-acceptor interactions from the molecular electrostatic potential maps. The level of theory mPW1PW91/6–31G(d)-LANL2DZ and ECP = LANL2DZ for the V atom was used. These insights about the compounds’ main interactions were supported by analyzing the noncovalent interactions utilizing the AIM and Hirshfeld surfaces approach. Molecular docking studies with small RNA fragments were used to assess the hypothesis that decavanadate’s anticancer activity could be attributed to its interaction with lncRNA molecules. Thus, a combination of three potentially beneficial components could be evaluated in various cancer cell lines.

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Section: Discussionmentioning

confidence: 99%

Tris(2-Pyridylmethylamine)V(O)2 Complexes as Counter Ions of Diprotonated Decavanadate Anion: Potential Antineoplastic Activity

et al. 2022

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“…The lncRNAs as ceRNAs lncRNAs are non-coding RNAs with a length typically exceeding 200 nucleotides (Refs [22][23][24][25]. Around 30 000 to 60 000 lncRNAs have been discovered in humans (Ref.…”

Section: The Cerna Crosstalk In Crcmentioning

confidence: 99%

Competing Endogenous RNAs (ceRNAs) in Colorectal Cancer: A Review

Akhbari

Zafari

Sheykhhasan

2022

Expert Rev. Mol. Med.

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Colorectal Cancer (CRC) is a common type of cancer and the second leading cause of cancer-related deaths worldwide. Competing endogenous RNAs (ceRNAs) that contain microRNA response elements (MREs) are involved in CRC progression. They can compete with microRNAs (miRNAs) via their MREs, which can combine non-coding and coding RNAs via complex ceRNA networks. This molecular interaction has the potential to affect a wide variety of biological processes, and many cancers can occur as a result of an imbalanced ceRNA network. Recent research indicates that numerous dysregulated RNAs in CRC may function as ceRNAs, regulating multiple biological functions of the tumor, including proliferation, apoptosis, metastasis, invasion, and migration. In this review, we discussed the role of protein-coding and non-coding RNAs, such as long non-coding RNAs (lncRNAs), circular RNAs (circRNAs), and pseudogenes, in the occurrence of ceRNA networks in CRC, and their function in cancer-related pathways, like Wnt/β-catenin, Mitogen-Activated Protein Kinase (MAPK), and Transforming Growth Factor β (TGF-β) signaling pathways. Additionally, we discussed validated ceRNAs associated with CRC biological functions and their potential role as novel prognostic and diagnostic biomarkers. Examining the role of ceRNAs in CRC sheds new light on cancer treatment and pathogenesis.

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“…The Encyclopedia of DNA Elements project revealed that approximately 80% of the human genome is transcribed into 14,880 long non-coding RNAs (lncRNAs) from 9,277 loci ( 15 ). LncRNAs are defined as non-protein coding transcripts longer than 200 nucleotides, although recent literature suggesting some lncRNAs can encode small peptides or small proteins ( 16 ). Currently, lncRNA research has moved to the forefront of human cancer research, as recent findings have revealed a crucial role for lncRNAs in gene modulation.…”

Section: Introductionmentioning

confidence: 99%

Use of long non-coding RNAs for the molecular diagnosis of papillary thyroid cancer

Kim

et al. 2022

Front. Oncol.

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ObjectiveImproved molecular testing for common somatic mutations and the identification of mRNA and microRNA expression classifiers are promising approaches for the diagnosis of thyroid nodules. However, there is a need to improve the diagnostic accuracy of such tests for identifying thyroid cancer. Recent findings have revealed a crucial role of long non-coding RNAs (lncRNAs) in gene modulation. Thus, we aimed to evaluate the diagnostic value of selected lncRNAs from The Atlas of Noncoding RNAs in Cancer (TANRIC) thyroid cancer dataset.MethodsLncRNAs in TANRIC thyroid cancer dataset that have significantly increased or decreased expression in papillary thyroid cancer (PTC) tissues were selected as candidates for PTC diagnosis. Surgical specimens from patients who underwent thyroidectomy were used to determine the separation capability of candidate lncRNAs between malignant and benign nodules. Fine needle aspiration samples were obtained and screened for candidate lncRNAs to verify their diagnostic value.ResultsLRRC52-AS1, LINC02471, LINC02082, UNC5B-AS1, LINC02408, MPPED2-AS1, LNCNEF, LOC642484, ATP6V0E2-AS1, and LOC100129129 were selected as the candidate lncRNAs. LRRC52-AS1, LINC02082, UNC5B-AS1, MPPED2-AS1, LNCNEF, and LOC100129129 expression levels were significantly increased or decreased in malignant nodules compared to those in benign nodules and paired normal thyroid tissues. The combination of LRRC52-AS1, LINC02082, and UNC5B-AS1 showed favorable results for the diagnosis of PTC from fine needle aspirates, with 88.9% sensitivity and 100.0% specificity.ConclusionsLncRNA expression analysis is a promising approach for advancing the molecular diagnosis of PTC. Further studies are needed to identify lncRNAs of additional diagnostic value.

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DLX6-AS1: a putative lncRNA candidate in multiple human cancers

Cited by 17 publications

References 78 publications

Tris(2-Pyridylmethylamine)V(O)2 Complexes as Counter Ions of Diprotonated Decavanadate Anion: Potential Antineoplastic Activity

Tris(2-Pyridylmethylamine)V(O)2 Complexes as Counter Ions of Diprotonated Decavanadate Anion: Potential Antineoplastic Activity

Competing Endogenous RNAs (ceRNAs) in Colorectal Cancer: A Review

Use of long non-coding RNAs for the molecular diagnosis of papillary thyroid cancer

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