2018
DOI: 10.1186/s13045-018-0663-8
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Long non-coding RNAs in esophageal cancer: molecular mechanisms, functions, and potential applications

Abstract: Esophageal cancer (EC) is the sixth leading cause of cancer-related death worldwide. The lack of early diagnostic biomarkers and effective prognostic indicators for metastasis and recurrence has resulted in the poor prognosis of EC. In addition, the underlying molecular mechanisms of EC development have yet to be elucidated. Accumulating evidence has demonstrated that lncRNAs play a vital role in the pathological progression of EC. LncRNAs may regulate gene expression through the recruitment of histone-modifyi… Show more

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Cited by 60 publications
(39 citation statements)
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References 158 publications
(158 reference statements)
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“…Long noncoding RNAs (IncRNAs) are defined as RNA transcripts that are longer than 200 nt with no potential of protein coding; however, they exhibit greater tissue specificity than miRNAs and messenger RNAs (mRNAs) [6]. It was reported that lncRNAs play an important role in regulating tumor progression and tumor biological behaviors such as gene expression, cell proliferation, cell differentiation, immune responses, and apoptosis, with the most crucial process being the regulation of competing endogenous RNAs (ceRNAs) [7,8]. e ceRNA hypothesis, first proposed by Salmena et al in 2011, gained a lot of attention in terms of tumorigenesis [9].…”
Section: Introductionmentioning
confidence: 99%
“…Long noncoding RNAs (IncRNAs) are defined as RNA transcripts that are longer than 200 nt with no potential of protein coding; however, they exhibit greater tissue specificity than miRNAs and messenger RNAs (mRNAs) [6]. It was reported that lncRNAs play an important role in regulating tumor progression and tumor biological behaviors such as gene expression, cell proliferation, cell differentiation, immune responses, and apoptosis, with the most crucial process being the regulation of competing endogenous RNAs (ceRNAs) [7,8]. e ceRNA hypothesis, first proposed by Salmena et al in 2011, gained a lot of attention in terms of tumorigenesis [9].…”
Section: Introductionmentioning
confidence: 99%
“…4 Accumulating evidences have showed that lncRNAs play active and functional roles in the development and progression of ESCC, via their regulatory effects on the proliferation, apoptosis, stemness, chemoresistance, invasion and metastasis of the cancer cells. 5 For example, knockdown of AK001796 led to an increase expression levels of p53 and p21, suggesting the role of AK001796 in regulating cell proliferation and cell cycle in ESCC cells. 6 Prostate cancer associated transcript-1 (PCAT-1), a lncRNA with a length of~1900 nt, was originally identified in prostate cancer by large-scale RNA-Seq analyses in 2011.…”
Section: Introductionmentioning
confidence: 92%
“…LncRNAs have attracted increasing attention in recent years. Although lncRNAs represent transcripts without protein-coding potential, they could control gene expression at multiple levels with epigenetic (e.g., DNA methylation, histone modifications, and chromatin remodeling), transcriptional (e.g., recruitment of RNA polymerase II, transcription factors and cofactors), and post-transcriptional (e.g., sponging of miR-NAs, alternative splicing, regulating mRNA stability, regulating translation, interacting with proteins) regulations [15][16][17]. Increasing evidence suggests that many lncRNAs show abnormal expression levels in various tumors [18].…”
Section: Introductionmentioning
confidence: 99%