Comprehensive Analysis of lncRNA-Mediated ceRNA Crosstalk and Identification of Prognostic Biomarkers in Wilms’ Tumor

Zheng, Hong; Li, Bai-Hui; Liu, Chang; Li, Jia; Liu, Fengting

doi:10.1155/2020/4951692

Cited by 24 publications

(22 citation statements)

References 35 publications

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“…Based on survival analysis, it was found that high expression of DUXAP8 and ELFN1-AS1 predicts poor prognosis in colon cancer (Chen et al, 2020). Zheng et al found that high expression of AC135178.1, LINC00535, and LMO7-AS1 correlated with poor survival in patients with childhood kidney cancer (Zheng H. et al, 2020). Cheng et al identified that the expression profiles of 3 lncRNAs by using a LASSO regression model, including CYP4A22-AS1, AP000695.6, and RP11-108M12.3, were significantly related to the prognosis of gastric carcinoma (Cheng, 2018).…”

Section: Discussionmentioning

confidence: 99%

A Prognostic Model Based on the Immune-Related lncRNAs in Colorectal Cancer

Qin

Wei

et al. 2021

Front. Genet.

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BackgroundColorectal cancer (CRC) is one of the most common malignant tumors with a poor prognosis. At present, the pathogenesis is not completely clear. Therefore, finding reliable prognostic indicators for CRC is of important clinical significance. In this study, bioinformatics methods were used to screen the prognostic immune-related lncRNAs of CRC, and a prognostic risk scoring model based on immune-related lncRNAs signatures were constructed to provide a basis for prognostic evaluation and immunotherapy of CRC patients.MethodsThe clinical information and RNA-seq data of CRC patients were obtained from The Cancer Genome Atlas (TCGA) database. The information of immune-related lncRNA was downloaded from the immunology database and analysis portal. The differentially expressed immune-related lncRNAs (IRLs) were screened by the edgeR package of R software. The prognostic value of IRLs was studied. Based on Cox regression analysis, a prognostic index (IRLPI) based on IRLs was established, and the relationship between the risk score and the clinicopathological characteristics of CRC was analyzed to determine the effectiveness of the risk score model as an independent prognostic factor.ResultsA total of 240 differentially expressed IRLs were identified between normal colorectal cancer tissues and normal colorectal cancer tissues, in which 8 were significantly associated with the survival of CRC patients (P < 0.05), including LINC00461, LINC01055, ELFN1-AS1, LMO7-AS1, CYP4A22-AS1, AC079612.1, LINC01351, and MIR31HG. And most of the lncRNAs related to survival were risk factors for the prognosis of CRC. The index established based on the 7 survival-related IRLs found to be highly accurate in monitoring CRC prognosis. Besides, IRLPI was significantly correlated with a variety of pathological factors and immune cell infiltration.ConclusionEight immune-related lncRNAs closely related to the prognosis of CRC patients were identified from the TCGA database. At the same time, an independent IRLPI was constructed, which may be helpful for clinicians to assess the prognosis of patients with CRC and to formulate individualized treatment plans.

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Section: Discussionmentioning

confidence: 99%

A Prognostic Model Based on the Immune-Related lncRNAs in Colorectal Cancer

Qin

Wei

et al. 2021

Front. Genet.

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“…In addition, XIST methylation status has been reported to modulate prostate cancer progression. 21 , 22 Since lncRNA has been implicated in WT, 23 we designed this study to elucidate the underlying mechanism of XIST-mediated WT progression. We found elevated XIST levels in WT tissues compared with adjacent non-tumor healthy tissues and also observed a positive correlation between XIST expression levels and survival duration.…”

Section: Discussionmentioning

confidence: 99%

Long Non-Coding RNA XIST Promotes Wilms Tumor Progression Through the miR-194-5p/YAP Axis

He¹,

Luo²,

Dong³

et al. 2021

CMAR

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Purpose Although the long non-coding RNA (lncRNA) X inactive-specific transcript (XIST) has been reported to have an anti-tumor effect in multiple malignant tumors, its role in Wilms tumor (WT) progression has not been characterized. Thus, we investigated the underlying mechanism by which XIST regulates WT progression. Patients and Methods We performed microarray analysis and real-time quantitative PCR (RT-qPCR) to detect the expression levels of XIST lncRNA, microRNA-194-5p (miR-194-5p), and YAP (yes-associated protein in Hippo pathway) in tumor and matched adjacent normal tissues and blood collected from 49 WT patients. We also conducted bioinformatics analyses to identify differentially expressed genes. We measured the effects of XIST overexpression and knockdown on cell proliferation, apoptosis, migration, and invasion, and its association with the miR-194-5p/YAP pathway in the rhabdoid G401cell line using flow cytometry, transwell assays, immunohistochemistry, Western blot analysis, and the dual luciferase reporter gene assay. Results We found that XIST lncRNA levels were increased in blood and tissue samples of WT patients, and this upregulation was significantly correlated with TNM staging and shorter survival time. Notably, we found that XIST upregulation correlated with miR-194-5p downregulation and YAP upregulation in WT tissues, suggesting that XIST regulates the miR-194-5p/YAP pathway. Conversely, XIST downregulation inhibited WT cell proliferation, migration, and invasion and induced apoptosis. Our study revealed the oncogenic role of the lncRNA XIST in WT and demonstrated its role as a competitive endogenous RNA that regulates the miR-194-5p/YAP pathway. Conclusion Our study demonstrates XIST’s potential as a clinical prognostic biomarker and therapeutic target for WT.

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“…Wilms' tumour (WT), or nephroblastoma, is the most common renal malignancy in children, accounting for nearly 7% of all cancers (89,90). A literature reported the discovery of abnormally increased SNHG6 levels in WT tissues.…”

Section: Lncrna Snhgs In Kidney Cancermentioning

confidence: 99%

Long Noncoding RNA Small Nucleolar Host Gene: A Potential Therapeutic Target in Urological Cancers

Yang

Zheng

et al. 2021

Front. Oncol.

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The incidence of urological cancer has been gradually increasing in the last few decades. However, current diagnostic tools and treatment strategies continue to have limitations. Substantial evidence shows that long noncoding RNAs (lncRNAs) play essential roles in carcinogenesis and the progression, treatment response and prognosis of multiple human cancers, including urological cancers, gastrointestinal tumours, reproductive cancers and respiratory neoplasms. LncRNA small nucleolar RNA host genes (SNHGs), a subgroup of lncRNAs, have been found to be dysregulated in tumour cell biology. In this review, we summarize the impacts of lncRNA SNHGs in urological malignancies and the underlying mechanisms.

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Comprehensive Analysis of lncRNA-Mediated ceRNA Crosstalk and Identification of Prognostic Biomarkers in Wilms’ Tumor

Cited by 24 publications

References 35 publications

A Prognostic Model Based on the Immune-Related lncRNAs in Colorectal Cancer

A Prognostic Model Based on the Immune-Related lncRNAs in Colorectal Cancer

Long Non-Coding RNA XIST Promotes Wilms Tumor Progression Through the miR-194-5p/YAP Axis

Long Noncoding RNA Small Nucleolar Host Gene: A Potential Therapeutic Target in Urological Cancers

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