Long non-coding RNAs in breast cancer metastasis

Mondal, Priya; Meeran, Syed Musthapa

doi:10.1016/j.ncrna.2020.11.004

Cited by 48 publications

(27 citation statements)

References 110 publications

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“…The migrated cells proliferate and survive in the secondary niche with the help of the components and cells within the tissue microenvironment 112 . Epithelial to mesenchymal transition (EMT) plays an essential role in tumor metastasis in which non-motile epithelial cells are transformed into motile mesenchymal cells containing invasive properties 113 .…”

Section: Circrnas Regulate the Hallmarks Of Breast Cancer In Interaction With Mirnasmentioning

confidence: 99%

Circular RNAs Interaction with MiRNAs: Emerging Roles in Breast Cancer

Gong¹,

Zhou²,

Sun³

2021

Int. J. Med. Sci.

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Despite significant advances in cancer therapy strategies, breast cancer is one of the most common and lethal malignancies worldwide. Characterization of a new class of RNAs using next-generation sequencing opened new doors toward uncovering etiopathogenesis mechanisms of breast cancer as well as prognostic and diagnostic biomarkers. Circular RNAs (circRNAs) are a novel class of RNA with covalently closed and highly stable structures generated primarily from the back-splicing of precursor mRNAs. Although circRNAs exert their function through various mechanisms, acting as a sponge for miRNAs is their primary mechanism of function. Furthermore, growing evidence has shown that aberrant expression of circRNAs is involved in the various hallmarks of cancers. This paper reviews the biogenesis, characteristics, and mechanism of functions of circRNAs and their deregulation in various cancers. Finally, we focused on the circRNAs roles as a sponge for miRNAs in the development, metastasis, angiogenesis, drug resistance, apoptosis, and immune responses of breast cancer.

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Section: Circrnas Regulate the Hallmarks Of Breast Cancer In Interaction With Mirnasmentioning

confidence: 99%

Circular RNAs Interaction with MiRNAs: Emerging Roles in Breast Cancer

Gong¹,

Zhou²,

Sun³

2021

Int. J. Med. Sci.

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“…reviews have discussed the role and significance of lncRNAs in the EMT of tumors (6,20,25). However, to the best of our knowledge, there has not been a review on the role of lncRNAs in EMT in HCC.…”

Section: Long Noncoding Rnas (Lncrnas)mentioning

confidence: 99%

“…LncRNAs are abnormally expressed in tumor cells and play an important regulatory role in tumor proliferation in such cancers as hepatocellular carcinoma ( 22 ), breast cancer ( 23 ), and gastric cancer ( 24 ). In addition, a large number of recent reviews have discussed the role and significance of lncRNAs in the EMT of tumors ( 6 , 20 , 25 ). However, to the best of our knowledge, there has not been a review on the role of lncRNAs in EMT in HCC.…”

Section: Long Noncoding Rnas (Lncrnas)mentioning

confidence: 99%

Role of LncRNAs in the Epithelial-Mesenchymal Transition in Hepatocellular Carcinoma

Yao

et al. 2021

Front. Oncol.

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Hepatocellular carcinoma (HCC) is a type of primary liver cancer with a high incidence and mortality rate. HCC develops insidiously, and most newly diagnosed cases are in the middle and advanced stages. The epithelial-mesenchymal transition (EMT) is a vital mechanism underlying metastasis in patients with advanced HCC. EMT is a multistep and complex procedure. The promotion and inhibition of EMT directly affect the migration and invasion of HCC. LncRNAs are involved in the epigenetic modification of genes, regulation of gene transcription, and posttranslational modification of proteins. LncRNAs also play important roles in regulating EMT progression in HCC and are promising biomarkers and therapeutic targets. This review focused on summarizing the mechanism by which lncRNAs regulate EMT in HCC. In particular, lncRNAs were reported to primarily act as RNA sponges, and the regulation of EMT involves major signaling pathways. Finally, we reviewed the mechanisms by which lncRNAs are involved in drug resistance and discussed the clinical prospects and potential challenges of utilizing lncRNAs to treat HCC.

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“…Alterations in the expression of noncoding RNAs (ncRNAs), including circular RNA (circRNA) [ 12 , 13 , 14 ], microRNA (miRNA) [ 15 , 16 ], and long noncoding RNAs (lncRNAs) [ 17 , 18 ] have been reported in breast tumors and in circulation in BC patients, with specific alterations in endocrine resistance [ 19 , 20 , 21 , 22 ]. miRNAs and lncRNAs are epigenetic regulators of human cancers [ 23 ].…”

Section: Introductionmentioning

confidence: 99%

Identification and Roles of miR-29b-1-3p and miR29a-3p-Regulated and Non-Regulated lncRNAs in Endocrine-Sensitive and Resistant Breast Cancer Cells

Muluhngwi

Klinge

2021

Cancers

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Despite improvements in the treatment of endocrine-resistant metastatic disease using combination therapies in patients with estrogen receptor α (ERα) primary tumors, the mechanisms underlying endocrine resistance remain to be elucidated. Non-coding RNAs (ncRNAs), including microRNAs (miRNA) and long non-coding RNAs (lncRNA), are targets and regulators of cell signaling pathways and their exosomal transport may contribute to metastasis. Previous studies have shown that a low expression of miR-29a-3p and miR-29b-3p is associated with lower overall breast cancer survival before 150 mos. Transient, modest overexpression of miR-29b1-3p or miR-29a-3p inhibited MCF-7 tamoxifen-sensitive and LCC9 tamoxifen-resistant cell proliferation. Here, we identify miR-29b-1/a-regulated and non-regulated differentially expressed lncRNAs in MCF-7 and LCC9 cells using next-generation RNA seq. More lncRNAs were miR-29b-1/a-regulated in LCC9 cells than in MCF-7 cells, including DANCR, GAS5, DSCAM-AS1, SNHG5, and CRND. We examined the roles of miR-29-regulated and differentially expressed lncRNAs in endocrine-resistant breast cancer, including putative and proven targets and expression patterns in survival analysis using the KM Plotter and TCGA databases. This study provides new insights into lncRNAs in endocrine-resistant breast cancer.

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Long non-coding RNAs in breast cancer metastasis

Cited by 48 publications

References 110 publications

Circular RNAs Interaction with MiRNAs: Emerging Roles in Breast Cancer

Circular RNAs Interaction with MiRNAs: Emerging Roles in Breast Cancer

Role of LncRNAs in the Epithelial-Mesenchymal Transition in Hepatocellular Carcinoma

Identification and Roles of miR-29b-1-3p and miR29a-3p-Regulated and Non-Regulated lncRNAs in Endocrine-Sensitive and Resistant Breast Cancer Cells

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