Long non-coding RNA SNHG5 regulates chemotherapy resistance through the miR-32/DNAJB9 axis in acute myeloid leukemia

Wang, Dan; Zeng, Ting; Lin, Zhi; Lu, Yan; Wang, Fenglin; Tang, Liyang; Wang, Leyuan; Tang, Daolin; Pan, Chaoyun; Yang, Minghua

doi:10.1016/j.biopha.2019.109802

Cited by 30 publications

(27 citation statements)

References 26 publications

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“…9 While Zhao et al reported that a suppressive role of SNHG5 was detected in gastric cancer. 10 Notably, it was also confirmed that SNHG5 exerted its oncogenic or suppressive effects on other human cancers including glioblastoma, 11 endometrial cancer, 12 acute myeloid leukemia, 13 chronic myeloid leukemia, 14 melanoma, 15 colorectal cancer 16 and osteosarcoma. 17 Additional clinical features analysis revealed that SNHG5 had a close correlation with tumor stage and overall survival.…”

Section: Introductionmentioning

confidence: 77%

“…38 In vitro, the cytotoxicity tests have confirmed that the overexpression of SNHG5 promoted adriamycin (ADM) resistance in AML cells, while SNHG5 knockdown had an opposite influence. 13 Interestingly, tumor volume and weight of xenograft models were also inhibited by SNHG5 knockdown. 38 Mechanically, SNHG5 mainly targeted miR-489-3p/sex determining region Y-box 4 (SOX4) axis or miR-32/DNAJB9 axis to act as an oncogenic factor in AML.…”

Section: Endometrial Cancer (Ec)mentioning

confidence: 99%

“…19 In addition, Wnt/β-catenin signaling, p38/MAPK signaling, mTOR signaling and ROCK signaling were significantly activated by SNHG5. 11,13,17,20 Surprisingly, Zhao et al also verified that several biological molecules or proteins, such as metastasisassociated genes protein 2 (MTA2), spermatogenesis associated serine rich 2 (SPATS2), p27 and TRAIL-R1 (DR4) were involved in the functional process of SNHG5. 10,[21][22][23] In this review, we generalized the latest progress in the expression, function and regulation of lncRNA SNHG5 in multiple human cancers (Table 1-2) and further explored its potential role as a clinical biomarker and therapeutic target for cancers ( Figure 1-3).…”

Section: Introductionmentioning

confidence: 99%

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Latest Advances of Long Non-Coding RNA SNHG5 in Human Cancers

Han¹,

Shi²,

Cao³

et al. 2020

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Long non-coding RNAs (lncRNAs) have been potent regulators in the initiation and development of human cancers regarding their biological roles in the modulation of dosage compensation effect, epigenetics and cell differentiation. Recently, aberrant expression of lncRNA small nucleolar RNA host gene 5 (SNHG5) has been observed in various solid tumors, which was intently correlated with tumor range, metastasis, pathological stage and prognosis. Additional mechanical investigation disclosed that SNHG5 was involved in multiple cellular activities, including proliferation, migration, invasion, cell-cycle, apoptosis and autophagy, via targeting miRNAs, signaling pathways and other biological molecules or proteins. In this review, we summarized the latest advances made towards understanding the roles of SNHG5 in human cancers and further discussed potential methods that could be adopted for clinical interventions.

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Section: Introductionmentioning

confidence: 77%

Section: Endometrial Cancer (Ec)mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Latest Advances of Long Non-Coding RNA SNHG5 in Human Cancers

Han¹,

Shi²,

Cao³

et al. 2020

OTT

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“…Information, including type name, the degree of correspondence between the probe and the original data, in addition to their active sequence structure information, are provided in Table I. After combining literature reports (37)(38)(39)(40)(41), four potential miRNAs which have been documented to serve a role in exosome-induced microglia autophagy were identified: rno-miR-32-3p, rno-miR-211-3p, rno-miR-188-5p and rno-miR-465-5p. RT-qPCR was performed to investigate the differences in the relative expression of these four potential target miRNAs in the microglia cells in the presence or absence of bone marrow-derived neural progenitor exosomes (Fig.…”

Section: Morphology and Particle Size Distribution Of Exosomes From Bmentioning

confidence: 99%

Bone marrow stromal cells‑derived exosomes target DAB2IP to induce microglial cell autophagy, a new strategy for neural stem cell transplantation in brain injury

et al. 2020

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Bone marrow stromal cells (MSCs) are a useful source of stem cells for the treatment of various brain injury diseases due to their abundant supply and fewer ethical problems compared with transplant treatment. However, the clinical application of MSCs is limited due to allograft rejection and immunosuppression in the process of MSCs transplantation. According to previous studies, microglial cell autophagy occurs following co-culture with MSCs. In the present study, exosomes were obtained from MSCs and subsequently characterized using transmission electron microscopy, atomic force microscopy and dynamic light scattering particle size analysis. The type of microRNAs (miRs) found in the exosomes was then analyzed via gene chip. The results demonstrated that microglial cell autophagy could be induced by exosomes. This mechanism was therefore investigated further via reverse transcription-quantitative PCR, western blotting and luciferase assays. These results demonstrated that exosomes from MSCs could induce microglial cell autophagy through the miR-32-mediated regulation of disabled homolog 2-interacting protein, thus providing a theoretical basis for the clinical application of miRs in MSCs.

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“…9 Also, several members of SNHG family including SNHG1, SNHG3, and SNHG5 have been found to be dysregulated and play a crucial role in leukemogenesis, and also have prognostic value in AML. [10][11][12][13][14] Since little studies investigated the expression and clinical implications of SNHGs in AML, we systemically determined the prognostic role of SNHGs expression in patients with AML.…”

Section: Introductionmentioning

confidence: 99%

Identification of Long Non-Coding RNA SNHG Family as Promising Prognostic Biomarkers in Acute Myeloid Leukemia

Shi¹,

Ding²,

Lü³

2020

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Background: Small nucleolar RNA host gene (SNHG) family members are newly recognized lncRNAs, which have been revealed to be oncogenes in several cancers. However, little studies investigated the expression and clinical implications of SNHGs in AML. Methods: Herein, we systemically determined the prognostic role of the expression of SNHG family members in acute myeloid leukemia (AML). Results: Among the expression of all SNHG family members, we identified that only SNHG7 and SNHG12 expression were found to have prognostic effects on overall survival (OS) and leukemia-free survival (LFS) in AML by Cox regression univariate analysis. Furthermore, Kaplan-Meier analysis showed that SNHG7 higher-expressed cases had markedly longer OS and LFS time than SNHG7 lower-expressed cases, whereas SNHG12 higher-expressed cases had markedly shorter OS and LFS time than SNHG12 lower-expressed cases. Interestingly, SNHG7 and SNHG12 expression were also associated with several prognosis-related clinical/molecular features such as white blood cell counts, FAB/cytogenetic classifications, IDH1 mutation, RUNX1 mutation, and NPM1 mutation. Despite the associations, Cox regression multivariate analysis confirmed the independent prognostic impact of SNHG7 and SNHG12 expression in AML. Notably, we further validated that both SNHG7 and SNHG12 expression was significantly increased in newly diagnosed AML patients. Conclusion: Our findings demonstrated that SNHG7 and SNHG12 expression act as independent prognostic indicators in AML.

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Long non-coding RNA SNHG5 regulates chemotherapy resistance through the miR-32/DNAJB9 axis in acute myeloid leukemia

Cited by 30 publications

References 26 publications

<p>Latest Advances of Long Non-Coding RNA SNHG5 in Human Cancers</p>

<p>Latest Advances of Long Non-Coding RNA SNHG5 in Human Cancers</p>

Bone marrow stromal cells‑derived exosomes target DAB2IP to induce microglial cell autophagy, a new strategy for neural stem cell transplantation in brain injury

<p>Identification of Long Non-Coding RNA <em>SNHG</em> Family as Promising Prognostic Biomarkers in Acute Myeloid Leukemia</p>

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