Long Non-coding RNA PVT1 Inhibits miR-30c-5p to Upregulate Rock2 to Modulate Cerebral Ischemia/Reperfusion Injury Through MAPK Signaling Pathway Activation

Zhang, Hao; Li, Minghong; Liang, Junquan; Li, Meng; Sun, Xiaoou

doi:10.1007/s12035-021-02539-y

Cited by 7 publications

(4 citation statements)

References 56 publications

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“…The previous observations substantiate these findings showing that SOX9 deletion in mice imparted a protective effect against transient middle cerebral artery occlusion injury, resulting in improved post-stroke neurological recovery and neuroprotection [73]. From in vitro oxygen-glucose deprivation and reperfusion models, it is evident that miR-30c targets 3 UTR of SOX9 [44], homeodomain-interacting protein kinase 1 (HIPK1) [72], and Rho-associated coiled-coil containing protein kinase 2 (ROCK2) [74] gene, which might attenuate oxidative stress and inflammation. Experimental data revealed that "miR-30c-5p antagomir" enhanced oxidative stress, inflammation, infarct area, and neurological deficits in a transient middle cerebral artery occlusion rat model.…”

Section: Mir-30c In Strokesupporting

confidence: 59%

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Emerging Role of MicroRNA-30c in Neurological Disorders

Kumar

Li²

2022

IJMS

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MicroRNAs (miRNAs or miRs) are a class of small non-coding RNAs that negatively regulate the expression of target genes by interacting with 3′ untranslated regions of target mRNAs to induce mRNA degradation and translational repression. The miR-30 family members are involved in the development of many tissues and organs and participate in the pathogenesis of human diseases. As a key member of the miR-30 family, miR-30c has been implicated in neurological disorders such as Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, and stroke. Mechanistically, miR-30c may act as a multi-functional regulator of different pathogenic processes such as autophagy, apoptosis, endoplasmic reticulum stress, inflammation, oxidative stress, thrombosis, and neurovascular function, thereby contributing to different disease states. Here, we review and discuss the biogenesis, gene regulation, and the role and mechanisms of action of miR-30c in several neurological disorders and therapeutic potential in clinics.

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Section: Mir-30c In Strokesupporting

confidence: 59%

“…These effects were prevented by the upregulation of miR-30c-5p by sevoflurane or flurbiprofen axetil pretreatments [44,72]. MiR-30c-5p attenuates pathological pathways such as mitogen-activated protein kinases by targeting ROCK2 [74], which presents a novel therapeutic target, miR-30c/ROCK2, in the pathogenesis of stroke.…”

Section: Mir-30c In Strokementioning

confidence: 98%

Emerging Role of MicroRNA-30c in Neurological Disorders

Kumar

Li²

2022

IJMS

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“…In the same way, a reduction in apoptosis and an increase in cell viability were reported in primary brain neurons induced by OGD/R. Noteworthy, PVT1 acts as a ceRNA for miR-30c-5p, modulating Rock2, which activates the mitogen-activated protein kinase (MAPK) pathway and exacerbates cerebral I/R injury [91].…”

Section: Lncrna Pvt1 In Hypoxic/anoxic Conditionsmentioning

confidence: 56%

LncRNAs and CircRNAs as Strategies against Pathological Conditions Caused by a Hypoxic/Anoxic State

Anchesi,

Schepici,

Mazzon

2023

Biomolecules

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Brain damage can be induced by oxygen deprivation. It is known that hypoxic or anoxic conditions can lead to changes in the expression levels of non-coding RNAs (ncRNAs), which, in turn, can be related to Central Nervous System (CNS) injuries. Therefore, it could be useful to investigate the involvement of non-coding RNAs (ncRNAs), as well as the underlying mechanisms which are able to modulate them in brain damage induced by hypoxic or anoxic conditions. In this review, we focused on recent research that associates these conditions with long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs). The results of this review demonstrate that the expression of both lncRNAs and circRNAs can be influenced by oxygen deprivation conditions and so they can contribute to inducing damage or providing neuroprotection by affecting specific molecular pathways. Furthermore, several experimental studies have shown that ncRNA activity can be regulated by compounds, thus also modifying their transcriptomic profile and their effects on CNS damages induced by hypoxic/anoxic events.

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“…MiR-182-5p and miR-193b-3p also exert neuroprotective effects in cerebral ischemia–reperfusion injury by negatively regulating the inflammatory response mediated by Toll-like receptor 4 and 5-lipoxygenase, respectively [ 101 , 102 ]. Additionally, miR-30c acts by inhibiting neuronal apoptosis in ischemia–reperfusion injury of the brain, thus suppressing the expression of SOX9/MAPK [ 103 , 104 ], while miR-449a downregulates the expression of amphiregulin (AREG) [ 105 ].…”

Section: Regulation Of Signaling Pathways In Ischemia and Reperfusion...mentioning

confidence: 99%

The Role of microRNAs in Epigenetic Regulation of Signaling Pathways in Neurological Pathologies

Tregub,

Ibrahimli,

Averchuk

et al. 2023

IJMS

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In recent times, there has been a significant increase in researchers’ interest in the functions of microRNAs and the role of these molecules in the pathogenesis of many multifactorial diseases. This is related to the diagnostic and prognostic potential of microRNA expression levels as well as the prospects of using it in personalized targeted therapy. This review of the literature analyzes existing scientific data on the involvement of microRNAs in the molecular and cellular mechanisms underlying the development of pathologies such as Alzheimer’s disease, cerebral ischemia and reperfusion injury, and dysfunction of the blood–brain barrier.

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Long Non-coding RNA PVT1 Inhibits miR-30c-5p to Upregulate Rock2 to Modulate Cerebral Ischemia/Reperfusion Injury Through MAPK Signaling Pathway Activation

Cited by 7 publications

References 56 publications

Emerging Role of MicroRNA-30c in Neurological Disorders

Emerging Role of MicroRNA-30c in Neurological Disorders

LncRNAs and CircRNAs as Strategies against Pathological Conditions Caused by a Hypoxic/Anoxic State

The Role of microRNAs in Epigenetic Regulation of Signaling Pathways in Neurological Pathologies

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