Long non-coding RNA POLR2E rs3787016 is associated with the risk of papillary thyroid carcinoma in Chinese population

Chen, Bifeng; Li, Jinfeng; Yi, Can; Jiao, Yuwei; Gu, Xiaoqing; Feng, Xianhong

doi:10.1016/j.prp.2018.04.008

Cited by 11 publications

(9 citation statements)

References 18 publications

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“…Similar results have also been reported in the Chinese and Iranian populations [14,16], albeit no significant association of rs3787016 with the PCa risk and standard prognostic parameters regarding PCa progression have been identified in the Serbian population [15]. Moreover, further studies have also been conducted for several other cancer types, and it has been reported that POLR2E rs3787016 polymorphism is significantly associated with the risk for breast cancer, cervical cancer, esophageal cancer, and papillary thyroid carcinoma [20][21][22][23],…”

Section: Discussionsupporting

confidence: 74%

“…According to a recent report, SNP rs3787016 (A>G), localized in the fourth intron of the RNA polymerase II subunit E (POLR2E) lncRNA gene [13], may serve as a genetic risk factor for different types of cancer including prostate cancer (PCa) [14][15][16], lung cancer [17], liver cancer [17], breast cancer [18,19], cervical cancer [18], esophageal cancer [20], papillary thyroid carcinoma [21], and glioma [22]. Although the literature presents conflicting notions, it is believed that rs3787016 may serve as a genetic factor that affects the susceptibility to cancer.…”

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confidence: 99%

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The POLR2E rs3787016 polymorphism is associated with susceptibility to and prognosis of gastric cancer

Zhang¹,

Wu²,

Li³

et al. 2021

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Long non-coding RNAs (lncRNAs) have been proposed as promising diagnostic and prognostic biomarkers for cancer. We investigated the associations of RNA polymerase II subunit E (POLR2E) rs3787016 polymorphism with the risk and prognosis of gastric cancer (GC). The study subjects included 368 GC patients who underwent surgical resection and 294 healthy volunteers, adjusted for age, gender, smoking status, alcohol status, and Helicobacter pylori infection status. The data was subjected to logistic regression analyses and revealed that the subjects carrying AA genotype of rs3787016 in POLR2E had a significant 1.85-1.98-fold increased risk of GC when compared with those carrying GG genotype (adjusted OR = 1.979, 95% CI = 1.198-3.267; p = 0.008) or those carrying AG/GG genotypes (adjusted OR = 1.847, 95% CI = 1.222-2.793; p = 0.004). For the GC patients, the AA genotype of rs3787016 was significantly correlated with poorly differentiated GC (p = 0.018), advanced TNM stage (p = 0.023), higher depth of invasion (p = 0.022), positive lymph node metastasis (p = 0.01), and worse overall survival (OS; p = 0.004). Multivariate analysis confirmed that the PO LR2E rs3787016 polymorphism is an independent prognostic factor for GC (HR = 1.668, 95% CI = 1.058-2.631; p = 0.028). Our cumulative results thus suggest that the presence of POLR2E rs3787016 polymorphism could serve as a genetic factor that affects the susceptibility to and the prognosis of GC.

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Section: Discussionsupporting

confidence: 74%

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confidence: 99%

The POLR2E rs3787016 polymorphism is associated with susceptibility to and prognosis of gastric cancer

Zhang¹,

Wu²,

Li³

et al. 2021

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“…Rs3787016, localizes to the fourth intron of RNA polymerase II polypeptide E (POLR2E) 16 gene, has been investigated by several researchers on its association with cancer risk [16,[30][31][32][33][34][35][36][37].The most important function of LncRNAs is involvement in the transcriptional or posttranscriptional regulation of gene expression [38]. Abnormal expressions of these RNAs facilitate tumor-cell proliferation, invasion and survival in cancer development and progression [39][40][41].…”

Section: Discussionmentioning

confidence: 99%

Association of rs3746444 in MiRNA-499 and rs3787016 in Long Non-coding RNAs POLR2E with Prostate Cancer: an updated meta-analysis and systematic review

Liu

Wang

et al. 2020

Preprint

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Background It has been proved that a significant proportion of prostate cancer diagnoses may be associated with a strong hereditary component. Micro-RNAs and Long Non-coding RNAs are a group of a noncoding small molecule, which play critical roles in signalling pathways, metabolism, apoptosis and cancer development. Exercising a meta-analysis to examine the relationship between rs3746444, rs3787016 and prostate cancer (PCa) risk was the main objective of our study. Results 10 case-control studies were included, while 6 on rs3787016 and 4 on rs3746444. On the whole, the genotypes carrying the T allele, in which were verified an increased risk between rs3787016 and PCa risk.( T vs C: odds ratio(OR) = 1.802, 95% CI 1.015–3.198, P value of heterogeneity(PH) = 0.00%; CT vs CC: OR = 1.179,95% CI 1.091–1.275, PH = 0.41; TT vs CC: .OR = 1.418, 95% CI 1.229–1.636, PH= 0.961; TT + CT vs CC: OR = 1.216, 95% CI 1.129–1.310, PH= 0.408; TT vs CT + CC: OR = 1.328, 95%CI 1.159–1.521, PH = 0.987). A vital relevance was performed by this meta-analysis in three models between rs3746444 and PCa risk, in which a tendency of increased PCa risk could be found (C vs T: OR = 1.197, 95% CI 1.035–1.384, PH= 0.837; CC vs TT: OR = 1. 137, 95% CI 0.813–1.590, PH = 0.392; CC + CT vs TT: OR = 1.426, 95% CI 1.166–1.743, PH= 0.406.). Conclusion Our findings proposed that rs3746444 in MiRNA-499 and rs3787016 in Long Non-coding RNAs POLR2E polymorphisms increased the risk of developing PCa. Further functional studies are warranted to reveal the role of the polymorphism in carcinogenesis.

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“…The expression and function of lncRNAs could be affected by genetic variations in the lncRNAs gene. In this regard, numerous investigations have examined the re-lationship between the POLR2E rs3787016 polymorphism and various cancers, including squamous cell carcinoma (ESCC) (23), prostate (20)(21)(22)24), thyroid (26), breast (27,28), cervical (28), liver, and lung cancer (25). In the current study, we conducted a meta-analysis to address the precise role of POLR2E rs3787016 in overall cancer susceptibility.…”

Section: Discussionmentioning

confidence: 99%

“…The POLR2E LncRNA gene is mapped to chromosome 19 (19p13). Several investigations have focused on identifying a relationship between the POLR2E rs3787016 polymorphism and the risk of cancer in various populations (20)(21)(22)(23)(24)(25)(26)(27)(28), but, overall, the findings have been inconsistent and conflicting. To comprehensively assess the correlation between the POLR2E rs3787016 polymorphism and cancer susceptibility, we designed and performed the current meta-analysis.…”

Section: Contextmentioning

confidence: 99%

Association between Long Non-coding RNA POLR2E rs3787016 Polymorphism and Cancer Susceptibility: A Meta-analysis of 8725 Cancer Cases and 10710 Controls

2020

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Objectives: Several studies have reported a correlation between the POLR2E rs3787016 polymorphism and cancer development, but findings are inconsistent. Therefore, we designed the current study to understand how rs3787016 polymorphism impacts cancer susceptibility. Methods: We searched the Scopus, Web of Science, and PubMed databases for studies related to the topic of interest published up to March 2019. A total of 11 relevant studies, encompassing 8,761 cancer cases and 10,534 controls, were retrieved and subject to quantitative analysis. The strength of the relationship was evaluated using the pooled odds ratios (ORs) with 95% confidence intervals (CIs). Results: Overall, the findings proposed a positive association between rs189037 polymorphism and susceptibility to cancer in homozygous (OR = 1.32, 95% CI = 1.11 - 1.57, P = 0.002, TT vs. CC), recessive (OR = 1.21, 95% CI = 1.06-1.39, P = 0.005, TT vs. CT + CC), and allele (OR = 1.12, 95% CI = 1.02-1.22, P = 0.021, T vs. C) genetic models. Stratified analysis showed that rs3787016 increased the risk of prostate and breast cancer. In addition, we found a significant association between the variant and increased cancer risk in Asian and Caucasian populations. Conclusions: In summary, the findings of the current meta-analysis suggest that the POLR2E rs3787016 polymorphism is an indicator of cancer susceptibility.

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Long non-coding RNA POLR2E rs3787016 is associated with the risk of papillary thyroid carcinoma in Chinese population

Cited by 11 publications

References 18 publications

The POLR2E rs3787016 polymorphism is associated with susceptibility to and prognosis of gastric cancer

The POLR2E rs3787016 polymorphism is associated with susceptibility to and prognosis of gastric cancer

Association of rs3746444 in MiRNA-499 and rs3787016 in Long Non-coding RNAs POLR2E with Prostate Cancer: an updated meta-analysis and systematic review

Association between Long Non-coding RNA POLR2E rs3787016 Polymorphism and Cancer Susceptibility: A Meta-analysis of 8725 Cancer Cases and 10710 Controls

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