Long non‐coding RNA MILNR1 retards colorectal cancer growth by inhibiting c‐Myc

Xia, Yang; Guo, Lili; Wang, Zifei; Wu, Shuang; Xu, Yuan; Zhang, Yaqin; Huang, Jing; Lei, Yu; Hu, Wanglai

doi:10.1002/cac2.12079

Cited by 6 publications

(5 citation statements)

References 11 publications

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“…Previous studies have reported that PTEN induces Akt termination by dephosphorylating phosphatidylinositol (3,4,5) trisphosphate (PI(3,4,5)P3) [33,34]. As anticipated, miR-202-5p mimics increased Akt activation in HCT116 cells in contrast to decreased Akt activation by miR-202-5p antagomirs (Fig.…”

Section: Mir-202-5p Directly Targets Pten and Increases Akt Activationsupporting

confidence: 71%

“…Colorectal cancer is the world's third most deadly cancer killing almost 700,000 people annually [1,2]. The pathogenesis of colorectal cancer (CRC) is still not clearly understood despite important progress being made in diagnostic and therapeutic strategies [3,4]. Therefore, the clarification of the molecular mechanisms that underlying colorectal carcinogenesis is instantly needed [5,6].…”

Section: Introductionmentioning

confidence: 99%

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MiRNA-202-5p promotes Colorectal Carcinogenesis through suppression of PTEN

Huang¹,

Zhang²,

Xu³

et al. 2021

J. Cancer

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Colorectal cancer (CRC) is still one of the leading causes of cancer-associated death in the modern society. The biological function of miR-202-5p for CRC development remains controversial, largely due to the fact that miR-202-5p can be tumor-suppressive or oncogenic in different contexts. Obtained results indicated that aberrant expression of miR-202-5p was observed in majority of human CRC samples and miR-202-5p was transcriptionally up-regulated by c-Myc. In addition, miR-202-5p functions to promote the activation of PI3K/Akt signaling pathway by directly suppressing PTEN. Silencing or enforced expression of miR-202-5p resulted in CRC cell proliferation inhibition and enhancement, respectively. Importantly, decreased PTEN level and increased phosphorylation of Akt were frequently associated with elevated miR-202-5p expression in colorectal cancer tissues. Increased miR-202-5p expression may serve as a tumor promoter by directly targeting PTEN in colorectal cancer.

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Section: Mir-202-5p Directly Targets Pten and Increases Akt Activationsupporting

confidence: 71%

Section: Introductionmentioning

confidence: 99%

MiRNA-202-5p promotes Colorectal Carcinogenesis through suppression of PTEN

Huang¹,

Zhang²,

Xu³

et al. 2021

J. Cancer

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“…For instance, EPIC1 (epigenetically induced lnCRNA1) binds to c-Myc protein to enhance c-Myc occupancy at target gene promoters [21] . We have also found that MILNR1 (c-Myc interacting long non-coding RNA 1) inhibits c-Myc transcriptional activity via interactions in cis [22] . Thirdly, the expression of c-Myc can also be controlled by lncRNAs, as occurs with lncRNA MIF (c-Myc inhibitory factor) that induces c-Myc degradation by increasing the expression of Fbxw7 (F-box and WD repeat domain containing 7), a well-known E3 ubiquitin ligase that targets c-Myc.…”

Section: Introductionmentioning

confidence: 70%

“…To dissect out the underlying molecular mechanisms responsible for the pro-survival activity of MEF, we hypothesized that, like many other regulatory lncRNAs, MEF acts through direct binding to protein effectors [ 22 , 25 ]. Of note, mass spectrometry analysis after RNA-pulldown assays against MEF identified hnRNPK (heterogeneous nuclear ribonucleoprotein K) and TRIM25 (tripartite motif containing 25) as candidate MEF binding proteins ( Fig.…”

Section: Resultsmentioning

confidence: 99%

Reciprocal regulation of lncRNA MEF and c-Myc drives colorectal cancer tumorigenesis

Wu,

Dai,

Zhu

et al. 2024

Neoplasia

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“…Molecular biomarkers or signatures are extremely valuable tools for the early diagnosis and accurate prognosis of cancer in modern times (8,9). Long non-coding RNAs (lncRNAs) are a class of nonprotein coding RNA molecules with more than 200 nucleotides (10) that have a variety of regulatory functions on cancer cell proliferation, genomic stability, metabolism, angiogenesis, immunity, and metastasis (11)(12)(13)(14)(15)(16). Moreover, lncRNAs were considered important candidate biomarkers due to their specific spatiotemporal expression and diversity in cancer (17).…”

Section: Introductionmentioning

confidence: 99%

Identification of a seven-lncRNAs panel that serves as a prognosis predictor and contributes to the malignant progression of laryngeal squamous cell carcinoma

et al. 2023

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BackgroundLaryngeal squamous cell carcinoma (LSCC) is one of the most frequent head and neck cancers worldwide. Long non-coding RNAs (lncRNAs) play a critical role in tumorigenesis. However, the clinical significance of lncRNAs in LSCC remains largely unknown.MethodsIn this study, transcriptome sequencing was performed on 107 LSCC and paired adjacent normal mucosa (ANM) tissues. Furthermore, RNA expression and clinical data of 111 LSCC samples were obtained from The Cancer Genome Atlas (TCGA) database. Bioinformatics analysis were performed to construct a model for predicting the overall survival (OS) of LSCC patients. Moreover, we investigated the roles of lncRNAs in LSCC cells through loss-of-function experiments.ResultsA seven-lncRNAs panel including ENSG00000233397, BARX1-DT, LSAMP-AS1, HOXB-AS4, MNX1-AS1, LINC01385, and LINC02893 was identified. The Kaplan–Meier analysis demonstrated that the seven-lncRNAs panel was significantly associated with OS (HR:6.21 [3.27-11.81], p-value<0.0001), disease-specific survival (DSS) (HR:4.34 [1.83-10.26], p-value=0.0008), and progression-free interval (PFI) (HR:3.78 [1.92-7.43], p-value=0.0001). ROC curves showed the seven-lncRNAs panel predicts OS with good specificity and sensitivity. Separately silencing the seven lncRNAs inhibited the proliferation, migration, and invasion capacity of LSCC cells.ConclusionCollectively, this seven-lncRNAs panel is a promising signature for predicting the prognosis of LSCC patients, and these lncRNAs could serve as potential targets for LSCC treatment.

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Long non‐coding RNA MILNR1 retards colorectal cancer growth by inhibiting c‐Myc

Cited by 6 publications

References 11 publications

MiRNA-202-5p promotes Colorectal Carcinogenesis through suppression of PTEN

MiRNA-202-5p promotes Colorectal Carcinogenesis through suppression of PTEN

Reciprocal regulation of lncRNA MEF and c-Myc drives colorectal cancer tumorigenesis

Identification of a seven-lncRNAs panel that serves as a prognosis predictor and contributes to the malignant progression of laryngeal squamous cell carcinoma

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