MiRNA-202-5p promotes Colorectal Carcinogenesis through suppression of PTEN

Huang, Jing; Zhang, Yaqin; Xu, Yuan; Xie, Qi; Wu, Shuang; Dong, Yi; Chen, Bing; Xia, Yang; Guo, Lili; Li, Qun; Hu, Wanglai

doi:10.7150/jca.56186

Cited by 4 publications

(4 citation statements)

References 40 publications

(61 reference statements)

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“…In contrast, downregulated miR-202-5p induced the converse effects in MCF-7/DOX cells promoting the inhibition of the PI3K/AKT pathway [ 13 ]. Similar oncogenic functions for miR-202 were observed in human colorectal cancer samples that showed c-Myc driven upregulation of miR-202-5p suppressed PTEN, which in turn increased the phosphorylation of AKT and enhanced CRC cell proliferation [ 36 ]. In addition, we have recently shown that inhibiting the direct interaction between miR-202 and PTEN negatively regulated the PI3K/AKT pathway and thereby reduced the migration and the invasion of highly metastatic breast cancer cells [ 17 ].…”

Section: The Mir-202/pten/akt Axis In Tumor Progressionmentioning

confidence: 71%

“…Lower levels of miR-202-5p in CRC tissues was found to be positively correlated with postoperative survival, and overexpression reduced the proliferation rate and inhibited tumor growth and metastasis of CRC cells [ 32 , 33 , 34 , 35 ]. On the other hand, a more recent study showed miR-202-5p up-regulation in CRC tumors and that its over-expression was critical for CRC cell viability [ 36 ]. However, based on the available preclinical and clinical information ( Table 2 ), a tumor suppressive role of miR-202 in colorectal tumorigenesis appears to predominate.…”

Section: Mir-202 As a Novel Gastrointestinal Tract Tumor Suppressormentioning

confidence: 99%

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The microRNA-202 as a Diagnostic Biomarker and a Potential Tumor Suppressor

Ahmed

Rajendran

Scherthan

2022

IJMS

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MicroRNA-202 (miR-202) is a member of the highly conserved let-7 family that was discovered in Caenorhabditis elegans and recently reported to be involved in cell differentiation and tumor biology. In humans, miR-202 was initially identified in the testis where it was suggested to play a role in spermatogenesis. Subsequent research showed that miR-202 is one of the micro-RNAs that are dysregulated in different types of cancer. During the last decade, a large number of investigations has fortified a role for miR-202 in cancer. However, its functions can be double-edged, depending on context they may be tumor suppressive or oncogenic. In this review, we highlight miR-202 as a potential diagnostic biomarker and as a suppressor of tumorigenesis and metastasis in several types of tumors. We link miR-202 expression levels in tumor types to its involved upstream and downstream signaling molecules and highlight its potential roles in carcinogenesis. Three well-known upstream long non-coding-RNAs (lncRNAs); MALAT1, NORAD, and NEAT1 target miR-202 and inhibit its tumor suppressive function thus fueling cancer progression. Studies on the downstream targets of miR-202 revealed PTEN, AKT, and various oncogenes such as metadherin (MTDH), MYCN, Forkhead box protein R2 (FOXR2) and Kirsten rat sarcoma virus (KRAS). Interestingly, an upregulated level of miR-202 was shown by most of the studies that estimated its expression level in blood or serum of cancer patients, especially in breast cancer. Reduced expression levels of miR-202 in tumor tissues were found to be associated with progression of different types of cancer. It seems likely that miR-202 is embedded in a complex regulatory network related to the nature and the sensitivity of the tumor type and therapeutic (pre)treatments. Its variable roles in tumorigenesis are mediated in part thought its oncogene effectors. However, the currently available data suggest that the involved signaling pathways determine the anti- or pro-tumorigenic outcomes of miR-202’s dysregulation and its value as a diagnostic biomarker.

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Section: The Mir-202/pten/akt Axis In Tumor Progressionmentioning

confidence: 71%

Section: Mir-202 As a Novel Gastrointestinal Tract Tumor Suppressormentioning

confidence: 99%

The microRNA-202 as a Diagnostic Biomarker and a Potential Tumor Suppressor

Ahmed

Rajendran

Scherthan

2022

IJMS

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“…MiR‐202‐5p suppression or forced expression led to reduction or stimulation of CRC cell growth, respectively. Furthermore, enhanced miR‐202‐5p expression was commonly linked to lower PTEN level and increased phosphorylation of Akt in CRC tissues 77 …”

Section: Pi3k/akt Regulation By Micrornas In Solid Tumorsmentioning

confidence: 99%

“…Furthermore, enhanced miR-202-5p expression was commonly linked to lower PTEN level and increased phosphorylation of Akt in CRC tissues. 77…”

Section: Colorectal Cancer (Crc)mentioning

confidence: 99%

Detailed role of microRNA‐mediated regulation of PI3K/AKT axis in human tumors

Al‐Hawary,

Ruzibakieva,

Gupta

et al. 2023

Cell Biochemistry & Function

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The regulation of signal transmission and biological processes, such as cell proliferation, apoptosis, metabolism, migration, and angiogenesis are greatly influenced by the PI3K/AKT signaling pathway. Highly conserved endogenous non‐protein‐coding RNAs known as microRNAs (miRNAs) have the ability to regulate gene expression by inhibiting mRNA translation or mRNA degradation. MiRNAs serve key role in PI3K/AKT pathway as upstream or downstream target, and aberrant activation of this pathway contributes to the development of cancers. A growing body of research shows that miRNAs can control the PI3K/AKT pathway to control the biological processes within cells. The expression of genes linked to cancers can be controlled by the miRNA/PI3K/AKT axis, which in turn controls the development of cancer. There is also a strong correlation between the expression of miRNAs linked to the PI3K/AKT pathway and numerous clinical traits. Moreover, PI3K/AKT pathway‐associated miRNAs are potential biomarkers for cancer diagnosis, therapy, and prognostic evaluation. The role and clinical applications of the PI3K/AKT pathway and miRNA/PI3K/AKT axis in the emergence of cancers are reviewed in this article.

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