Long non-coding RNA MALAT1 promotes gastric cancer tumorigenicity and metastasis by regulating vasculogenic mimicry and angiogenesis

Li, Yue; Wu, Zhenzhen; Jia, Yuping; Sun, Li; Li, Lin; Huang, Na; Bin, Jianping; Liao, Yulin; Liao, Wangjun

doi:10.1016/j.canlet.2017.02.035

Cited by 175 publications

(130 citation statements)

References 37 publications

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“…Loss of MALAT1 inhibited endothelial cell proliferation and reduced neonatal retina vascularization. The role of MALAT1 in promoting angiogenesis is further confirmed by two other groups in neuroblastoma and gastric cancer . LncRNA MVIH is another noncoding RNA, which is associated with microvascular invasion and tumor node metastasis in hepatocellular carcinoma .…”

Section: Molecular Mechanism Of Lncrnas In Cancer Metastasismentioning

confidence: 67%

“…56 is further confirmed by two other groups in neuroblastoma 58 and gastric cancer. 59 LncRNA MVIH is another noncoding RNA, which is associated with microvascular invasion and tumor node metastasis in hepatocellular carcinoma. 60 Yuan et al reported that MVIH activates tumor-inducing angiogenesis by inhibiting the secretion of phosphoglycerate kinase 1 (PGK1), which is involved in the angiogenic process as a disulfide reductase.…”

Section: Lncrnas In Angiogenesismentioning

confidence: 99%

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Molecular mechanisms of long noncoding RNAs‐mediated cancer metastasis

Egranov

Yang

et al. 2019

Genes Chromosomes & Cancer

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Cancer metastasis is a multistep process that requires cancer cells to leave the primary site, survive in the blood stream, and finally colonize at a distant organ. It is the major cause of cancer morbidity and mortality. The organ‐specific colonization requires close interaction and communication between cancer cells and host organs. Noncoding RNAs represent the majority of the transcriptome, with long noncoding RNAs (lncRNAs) making up a significant proportion. It has been suggested that lncRNAs play a key role in all stages of tumorigenesis and metastasis. This review will provide an overview of how lncRNAs are involved in cancer cell colonization in specific organ sites and the underlying mechanisms as well as therapeutic strategies.

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Section: Molecular Mechanism Of Lncrnas In Cancer Metastasismentioning

confidence: 67%

Section: Lncrnas In Angiogenesismentioning

confidence: 99%

Molecular mechanisms of long noncoding RNAs‐mediated cancer metastasis

Egranov

Yang

et al. 2019

Genes Chromosomes & Cancer

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“…Mounting evidence, including ours, highlights that lncRNAs play powerful oncogenic or tumor-suppressive roles in nearly all aspects of tumor progression, including proliferation, apoptosis, cell cycle, invasion and metastasis. [6][7][8][9][10][11][12] Regarding metastasis, a small number of lncRNAs, such as linc-RoR, TUG1, NEAT1, PVT1, H19, MALAT1 and BDNF-AS, are reportedly involved in cancer metastasis via the regulation of EMT. [13][14][15][16][17][18] Previously, we isolated a novel estrogen (E2)-induced lncRNA, TC0101441, in EOC cells based on microarray analysis, revealing that this lncRNA is located on chromosome 1 (chr1: 202,377,159: 202,378,011; hg18, http://genome.ucsc.edu/), contains two exons and encodes a 765 bp lncRNA molecule.…”

Section: Introductionmentioning

confidence: 99%

Long noncoding RNA TC0101441 induces epithelial–mesenchymal transition in epithelial ovarian cancer metastasis by downregulating KiSS1

Lin

Tang

Zheng

et al. 2019

Intl Journal of Cancer

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Peritoneal metastasis is a critical feature and clinical challenge in epithelial ovarian cancer (EOC). We previously identified a novel long noncoding RNA (lncRNA, TC0101441) in epithelial ovarian cancer (EOC) using microarrays. However, the impact of TC0101441 on EOC metastasis and prognosis remains unclear. TC0101441 expression in EOC tissues and its correlation with clinicopathological factors and prognosis were examined. A series of in vitro and in vivo assays were performed to elucidate the roles and mechanism of TC0101441 in EOC metastasis. We found that TC0101441 levels were elevated in EOC tissues compared with those in normal controls and significantly correlated with an advanced clinical stage and lymph node metastasis. TC0101441 was determined to be an independent prognostic predictor of overall survival (OS) and disease‐free survival (DFS). Furthermore, loss‐of‐function assays showed that TC0101441 promoted the invasive and metastatic capacities of EOC cells both in vitro and in vivo. Mechanistically, the prometastatic effects of TC0101441 were linked to the induction of epithelial–mesenchymal transition (EMT). Importantly, KiSS1 was identified as a downstream target gene of TC0101441 and was downregulated by TC0101441 in EOC cells. After TC0101441 was silenced, the corresponding phenotypes of EOC cell invasion and EMT were reversed by the overexpression of KiSS1. Taken together, our data suggest that TC0101441 functions as a potential promigratory/invasive oncogene by promoting EMT and metastasis in EOC through downregulation of KiSS1, which may represent a novel prognostic marker and therapeutic target in EOC.

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“…For example, lncRNA urothelial cancer associated 1 ( UCA1 ) is upregulated in gastric cancer tissues, and promotes the growth and cell cycle process through binding to enhancer of zeste 2 polycomb repressive complex 2 subunit (EZH2) and facilitating cyclin D1 expression in gastric cancer cells [14]. Metastasis-associated lung adenocarcinoma transcript 1 ( MALAT1 ) increases the tumorigenesis and metastasis of gastric cancer via facilitating vasculogenic mimicry and angiogenesis [15]. LncRNA XLOC_010235 is over-expressed in gastric cancer, and promotes the metastasis by associating with snail family zinc finger 1 [16].…”

Section: Introductionmentioning

confidence: 99%

Ets-1 promoter-associated noncoding RNA regulates the NONO/ERG/Ets-1 axis to drive gastric cancer progression

Chen

Hong

et al. 2018

Oncogene

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Emerging studies have indicated the essential functions of long noncoding RNAs (lncRNAs) during cancer progression. However, whether lncRNAs contribute to the upregulation of v-ets erythroblastosis virus E26 oncogene homolog 1 (Ets-1), an established oncogenic protein facilitating tumor invasion and metastasis, in gastric cancer remains elusive. Herein, we identified Ets-1 promoter-associated noncoding RNA (pancEts-1) as a novel lncRNA associated with the gastric cancer progression via mining of publicly available datasets and rapid amplification of cDNA ends. RNA pull-down, RNA immunoprecipitation, in vitro binding, and RNA electrophoretic mobility shift assays indicated the binding of pancEts-1 to non-POU domain containing octamer binding (NONO) protein. Mechanistically, pancEts-1 facilitated the physical interaction between NONO and Ets related gene (ERG), resulting in increased ERG transactivation and transcription of Ets-1 associated with gastric cancer progression. In addition, pancEts-1 facilitated the growth and aggressiveness of gastric cancer cells via interacting with NONO. In gastric cancer tissues, pancEts-1, NONO, and ERG were upregulated and significantly correlated with Ets-1 levels. High levels of pancEts-1, NONO, ERG, or Ets-1 were respectively associated with poor survival of gastric cancer patients, whereas simultaneous expression of all of them (HR = 3.012, P = 0.105) was not an independent prognostic factor for predicting clinical outcome. Overall, these results demonstrate that lncRNA pancEts-1 exhibits oncogenic properties that drive the progression of gastric cancer via regulating the NONO/ERG/Ets-1 axis.

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Long non-coding RNA MALAT1 promotes gastric cancer tumorigenicity and metastasis by regulating vasculogenic mimicry and angiogenesis

Cited by 175 publications

References 37 publications

Molecular mechanisms of long noncoding RNAs‐mediated cancer metastasis

Molecular mechanisms of long noncoding RNAs‐mediated cancer metastasis

Long noncoding RNA TC0101441 induces epithelial–mesenchymal transition in epithelial ovarian cancer metastasis by downregulating KiSS1

Ets-1 promoter-associated noncoding RNA regulates the NONO/ERG/Ets-1 axis to drive gastric cancer progression

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