Long non-coding RNA MALAT1 interacts with miR-124 and modulates tongue cancer growth by targeting JAG1

Abstract

Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), a long non-coding RNA (lncRNA), was the earliest discovered to be correlated with cancer and contributes to the initiation and development of several types of tumors. Dysregulation of MALAT1 expression is frequently observed in many types of cancer such as gastric cancer, esophageal squamous cell carcinoma and glioma. To date, the role of MALAT1 and the underlying mechanisms in tongue cancer development remain unclear. In the present study, we studied the influence of MALAT1 on tongue cancer cell lines and clinical tongue cancer samples so as to detect its function and the underlying mechanism. In the present study, lncRNA-MALAT1 was specifically upregulated in tongue cancer cell lines and overexpression promoted tongue cancer cell growth by targeting miR-124. Knockdown of MALAT1 suppressed the growth and invasion of human tongue cancer cells and inhibited metastasis in vitro and in vivo. In addition, miR-124-dependent jagged1 (JAG1) regulation was required for MALAT1-induced tongue cancer cell growth. Our data revealed that MALAT1 inhibited tongue cancer cell growth and metastasis through miR-124-dependent JAG1 regulation. In conclusion, we revealed that MALAT1 may play an oncogenic role by increasing proliferation and metastasis of tongue cancer and is a potential therapeutic target in human tongue cancer.

MALAT1 modulates the autophagy of retinoblastoma cell through miR‐124‐mediated stx17 regulation

“…By sponging miR‐124 in Parkinson disease, MALAT1 contributes to cell apoptosis . Through direct binding to miR‐124, MALAT1 inhibits miR‐124 expression, and subsequently upregulates the expression of JAG1, a downstream target of miR‐124 in tongue cancer . More importantly, miR‐124 itself has been reported to regulate autophagy.…”

“…In addition to MALAT1, miR‐124, a known tumor suppressor, has also been reported to regulate cell apoptosis and autophagy in dopaminergic neurons . More importantly, MALAT1 exerts its functions in diseases, at least partially through interaction with miR‐124 …”

Genomic Insight into the Role of lncRNAs in Cancer Susceptibility

“…Hypoxia-inducible factor-1α antisense transcript ( HIF1A-AS ) is also a well-established oncogene associated with renal cancer [9,10]. Two lncRNAs named MALAT1 and H19 were found to be oncogenes in lung cancer and other cancer types [11,12,13,14,15,16]. Both of them need to interact with microRNAs to execute functions.…”

Clinical Analysis of Long Non-coding RNA (LncRNA): Therapeutic Targeting of Tumorigenesis and Tumor Disease

“…Some lncRNAs such as RP1, RP4, RP11 and RP13 profiles are going to be used to study tumor prognosis with up-expressed and down expression in breast cancer [14] . The oncogenic lncRNA and tumor suppressive lncRNA profiles are discovered to relate with many tumor diseases, including hepatocellular carcinoma, lung cancer, colorectal cancer, breast cancer, prostate cancer, stomach cancer and glioblastoma [15] . lncRNAs Biomarkers in circulating lncRNA and body liquid…”