Genomic Insight into the Role of lncRNAs in Cancer Susceptibility

Abstract

With the development of advanced genomic methods, a large amount of long non-coding RNAs (lncRNAs) have been found to be important for cancer initiation and progression. Given that most of the genome-wide association study (GWAS)-identified cancer risk SNPs are located in the noncoding region, the expression and function of lncRNAs are more likely to be affected by the SNPs. The SNPs may affect the expression of lncRNAs directly through disrupting the binding of transcription factors or indirectly by affecting the expression of regulatory factors. Moreover, SNPs may disrupt the interaction between lncRNAs and other RNAs or proteins. Unveiling the relationship of lncRNA, protein-coding genes, transcription factors and miRNAs from the angle of genomics will improve the accuracy of disease prediction and help find new therapeutic targets.

Association between lncRNA‐H19 polymorphisms and hepatoblastoma risk in an ethic Chinese population

“…29 Emerging evidence has suggested that lncRNA SNPs can affect the function and expression of cancer-associated genes, leading to increased cancer susceptibility. 30 In this case-control study of 213 patients with hepatoblastoma and 958 healthy controls, we found that rs2839698, rs3024270 and rs217727 H19 polymorphisms are significantly associated with hepatoblastoma susceptibility.…”

Association between lncRNA‐H19 polymorphisms and hepatoblastoma risk in an ethic Chinese population

“…29 Emerging evidence has suggested that lncRNA SNPs can affect the function and expression of cancer-associated genes, leading to increased cancer susceptibility. 30 In this case-control study of 213 patients with hepatoblastoma and 958 healthy controls, we found that rs2839698, rs3024270 and rs217727 H19 polymorphisms are significantly associated with hepatoblastoma susceptibility.…”

Genetic Polymorphisms of Long Non-coding RNA Linc00312 Are Associated With Susceptibility and Predict Poor Survival of Nasopharyngeal Carcinoma

“…A great number of studies have indicated SNPs of lncRNA have great potential as predictive markers for carcinogenesis, prognosis, and drug resistance (Gao and Wei, 2017;Minotti et al, 2018). Our previous findings have suggested NPC patients with lncRNA GAS5 rs2067079 CT genotypes were linked with an obviously increased risk of severe myelosuppression during concurrent radiochemotherapy period compared with CC genotype carriers (Guo et al, 2017).…”

Biology and Clinical Implications of the 19q13 Aggressive Prostate Cancer Susceptibility Locus

“…PCAT19 codes an IncRNA and harbors rs11672691 in its second intron. Given that many IncRNAs play an important role in cancer initiation and progression (Gao and Wei, 2017; Kopp and Mendell, 2018), we hypothesized that PCAT19 and CEACAM21 may possess unknown function in PCa. To test this, we performed knockdown assays using lentivirus-mediated short hairpin (shRNA) against CEACAM21 or PCAT19 in multiple PCa cell models.…”

“…As reviewed extensively elsewhere (Gao and Wei, 2017), recent studies reported the association of IncRNAs with PCa and other types of cancer susceptibility. Notably, in a recent work (Guo et al, 2016), the PCa risk variant of rs7463708 was found to disrupt the binding of ONECUT2 and increased the expression of PCAT1 , a well-studied PCa-associated IncRNA (Gao and Wei, 2017). These findings defined the relationships between IncRNAs and SNPs within major part of human genome with non-protein-coding capacity.…”

Association between lncRNA‐H19 polymorphisms and hepatoblastoma risk in an ethic Chinese population

“…29 Emerging evidence has suggested that lncRNA SNPs can affect the function and expression of cancer-associated genes, leading to increased cancer susceptibility. 30 In this case-control study of 213 patients with hepatoblastoma and 958 healthy controls, we found that rs2839698, rs3024270 and rs217727 H19 polymorphisms are significantly associated with hepatoblastoma susceptibility.…”

Genetic Polymorphisms of Long Non-coding RNA Linc00312 Are Associated With Susceptibility and Predict Poor Survival of Nasopharyngeal Carcinoma

“…A great number of studies have indicated SNPs of lncRNA have great potential as predictive markers for carcinogenesis, prognosis, and drug resistance (Gao and Wei, 2017;Minotti et al, 2018). Our previous findings have suggested NPC patients with lncRNA GAS5 rs2067079 CT genotypes were linked with an obviously increased risk of severe myelosuppression during concurrent radiochemotherapy period compared with CC genotype carriers (Guo et al, 2017).…”

Biology and Clinical Implications of the 19q13 Aggressive Prostate Cancer Susceptibility Locus

“…PCAT19 codes an IncRNA and harbors rs11672691 in its second intron. Given that many IncRNAs play an important role in cancer initiation and progression (Gao and Wei, 2017; Kopp and Mendell, 2018), we hypothesized that PCAT19 and CEACAM21 may possess unknown function in PCa. To test this, we performed knockdown assays using lentivirus-mediated short hairpin (shRNA) against CEACAM21 or PCAT19 in multiple PCa cell models.…”

“…As reviewed extensively elsewhere (Gao and Wei, 2017), recent studies reported the association of IncRNAs with PCa and other types of cancer susceptibility. Notably, in a recent work (Guo et al, 2016), the PCa risk variant of rs7463708 was found to disrupt the binding of ONECUT2 and increased the expression of PCAT1 , a well-studied PCa-associated IncRNA (Gao and Wei, 2017). These findings defined the relationships between IncRNAs and SNPs within major part of human genome with non-protein-coding capacity.…”

Association between lncRNA‐H19 polymorphisms and hepatoblastoma risk in an ethic Chinese population

“…29 Emerging evidence has suggested that lncRNA SNPs can affect the function and expression of cancer-associated genes, leading to increased cancer susceptibility. 30 In this case-control study of 213 patients with hepatoblastoma and 958 healthy controls, we found that rs2839698, rs3024270 and rs217727 H19 polymorphisms are significantly associated with hepatoblastoma susceptibility.…”

Genetic Polymorphisms of Long Non-coding RNA Linc00312 Are Associated With Susceptibility and Predict Poor Survival of Nasopharyngeal Carcinoma

“…A great number of studies have indicated SNPs of lncRNA have great potential as predictive markers for carcinogenesis, prognosis, and drug resistance (Gao and Wei, 2017;Minotti et al, 2018). Our previous findings have suggested NPC patients with lncRNA GAS5 rs2067079 CT genotypes were linked with an obviously increased risk of severe myelosuppression during concurrent radiochemotherapy period compared with CC genotype carriers (Guo et al, 2017).…”

Biology and Clinical Implications of the 19q13 Aggressive Prostate Cancer Susceptibility Locus

“…PCAT19 codes an IncRNA and harbors rs11672691 in its second intron. Given that many IncRNAs play an important role in cancer initiation and progression (Gao and Wei, 2017; Kopp and Mendell, 2018), we hypothesized that PCAT19 and CEACAM21 may possess unknown function in PCa. To test this, we performed knockdown assays using lentivirus-mediated short hairpin (shRNA) against CEACAM21 or PCAT19 in multiple PCa cell models.…”

“…As reviewed extensively elsewhere (Gao and Wei, 2017), recent studies reported the association of IncRNAs with PCa and other types of cancer susceptibility. Notably, in a recent work (Guo et al, 2016), the PCa risk variant of rs7463708 was found to disrupt the binding of ONECUT2 and increased the expression of PCAT1 , a well-studied PCa-associated IncRNA (Gao and Wei, 2017). These findings defined the relationships between IncRNAs and SNPs within major part of human genome with non-protein-coding capacity.…”