Long non‐coding RNA linc01433 promotes migration and invasion in non‐small cell lung cancer

Qian, Banglun; Wang, Xiang; Mao, Chao; Jiang, Yiqun; Shi, Ying; Chen, Ling; Liu, Shuang; Wang, Bin; Pan, Shu; Tao, Yongguang; Shi, Hongcan

doi:10.1111/1759-7714.12623

Cited by 20 publications

(20 citation statements)

References 49 publications

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“…A recent study has reported over-expression of LINC01433 in NSCLC samples compared with the normal non-tumoral tissues. Their in vitro experiments also verified the results of the previous study regarding the oncogenic role of this lncRNA [8]. Based on these studies, we aimed to confirm these results in Iranian NSCLC patients.…”

Section: Introductionsupporting

confidence: 82%

“…There was no significant difference in the expression of LINC01433 between tumoral and non-tumoral tissues (expression ratio 0.67, p = 0.42). Expression of this lncRNA was not associated with any [8], which was not revealed in our study. In brief, our study did not verify the overexpression of LINC01433 in NSCLC Iranian patients despite the reported oncogenic role of this lncRNA.…”

Section: Expression Assaycontrasting

confidence: 77%

“…Another long intergenic RNA with possible participation of lung carcinogenesis has been LINC01433. Two independent groups have demonstrated oncogenic roles of this lncRNAs via in vitro assays [7,8]. Moreover, the results of in vivo experiments support such role in animal models [7].…”

Section: Discussionmentioning

confidence: 80%

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Expression Analysis of the Long Non-Coding RNA LINC01433 in Lung Cancer

Niazi¹,

Garazhian²,

Esfandi³

et al. 2019

Klin Onkol

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Background: Lung cancer is one of the most fatal human cancers both in males and females. This type of cancer is categorized to different subtypes among them is non-small cell lung cancer (NSCLC). NSCLC accounts for about 80% of all cases. Long non-coding RNAs (lncRNAs) have been shown to influence the pathogenic course of lung cancer. However, the contribution of LINC01433 lncRNA in this type of cancer in Iranian patients is not clear. Purpose: In the current project, we evaluated expression of LINC01433 in 42 NSCLC samples and their paired non-tumoral tissues using quantitative real time polymerase chain reaction method. Samples were collected from patients admitted to Labbafinejad Hospital during 2016-2017. Results: There was no significant difference in the expression of LINC01433 between tumoral and non-tumoral tissues (expression ratio 0.67, p = 0.42). Expression of this lncRNA was not associated with any of clinical and demographic data including age, gender, smoking history, stage or cancer subtype. Conclusion: Based on the similar expression levels of this lncRNA between tumoral and non-tumoral tissues and lack of association between expression levels and clinical data, this lncRNA is not a possible contributor to lung cancer in Iranian patients. However, expression analysis of this lncRNA in larger sample sizes is needed to verify our results. Key wordslung cancer -expression -long non-coding RNA Souhrn Východiska: Karcinom plic je jedním z nejfatálnějších karcinomů jak u mužů, tak u žen. Tento typ karcinomu je rozdělen do různých podtypů, k nimž patří nemalobuněčný karcinom plic (non-small cell lung cancer -NSCLC). NSCLC představuje asi 80 % všech případů. Bylo prokázáno, že dlouhé nekódující RNA (long non-coding RNA -lncRNA) ovlivňují patogenezi karcinomu plic. Vliv lncRNA LINC01433 na tento typ karcinomu u íránských pacientů však není jednoznačný. Cíl: V tomto projektu jsme pomocí kvantitativní polymerázové řetězové reakce v reálném čase vyhodnotili expresi LINC01433 ve 42 vzorcích NSCLC a jejich párových nenádorových tkáních. Vzorky byly odebrány od pacientů přijatých do nemocnice Labbafinejad v letech 2016-2017. Výsledky: Nebyl nalezen žádný významný rozdíl v expresi LINC01433 mezi nádorovými a nenádorovými tkáněmi (poměr exprese 0,67; p = 0,42). Exprese této lncRNA nebyla spojena s žádnými klinickými a demografickými údaji vč. věku, pohlaví, historie kouření, stadia nebo podtypu karcinomu. Závěr: Na základě podobných hladin exprese této lncRNA mezi nádorovými a nenádorovými tkáněmi a chybějící asociace mezi hladinami exprese a klinickými údaji nemá tato lncRNA vliv na karcinom plic u íránských pacientů. K ověření našich výsledků je však nutná analýza exprese této lncRNA na větším vzorku pacientů. Klíčová slovakarcinom plic -exprese -dlouhé nekódující RNA The authors declare they have no potential conflicts of interest concerning drugs, products, or services used in the study.Autoři deklarují, že v souvislosti s předmětem studie nemají žádné komerční zájmy.The Editorial Board declares that the manu...

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Section: Introductionsupporting

confidence: 82%

Section: Expression Assaycontrasting

confidence: 77%

See 1 more Smart Citation

Expression Analysis of the Long Non-Coding RNA LINC01433 in Lung Cancer

Niazi¹,

Garazhian²,

Esfandi³

et al. 2019

Klin Onkol

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“…Various studies have suggested that the dysregulation of lncRNA is associated with lung cancer. Compared to normal lung tissue, linc01433 is significantly overexpressed and promotes migration and invasion in NSCLC . LINC00094 is highly expressed in lung cancer tissues and could be a molecular target for therapy for smoking‐related lung cancer .…”

Section: Long Non‐coding Rnas (Lncrnas) and Non‐small Cell Lung Cancementioning

confidence: 99%

“…Compared to normal lung tissue, linc01433 is significantly overexpressed and promotes migration and invasion in NSCLC. 13 LINC00094 is highly expressed in lung cancer tissues and could be a molecular target for therapy for smoking-related lung cancer. 14 In recent years, emerging evidence has confirmed the role of lncRNAs in drug resistance.…”

Section: Introductionmentioning

confidence: 99%

Role of long non‐coding RNA in drug resistance in non‐small cell lung cancer

Wang

et al. 2018

Thoracic Cancer

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Lung cancer is the leading cause of cancer‐associated death, and non‐small cell lung cancer (NSCLC) accounts for 85% of all lung cancer cases. Many drugs have been used to treat NSCLC in order to improve patient prognosis. Platinum‐based chemotherapy is the first‐line treatment for locally advanced or metastatic patients. For patients with activating EGFR mutations, tyrosine kinase inhibitors are the best treatment choice. NSCLC initially exhibits an excellent response to treatment; however, acquired resistance has been observed in many patients, leading to ineffective treatment. Clinical resistance is an impediment in the treatment of patients with advanced NSCLC. Many sequencing technologies have shown that long non‐coding RNA (lncRNA) is expressed differently between drug‐resistant and drug‐sensitive lung cancer cells. We review the literature on lncRNA in drug resistance of NSCLC. The aim of this review is to gain insight into the molecular mechanisms of drug resistance, mainly focusing on the role of lncRNA in NSCLC.

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LINC01433 promotes hepatocellular carcinoma progression via modulating the miR‐1301/STAT3 axis

Huang¹,

Zhang

et al. 2018

Journal Cellular Physiology

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Long noncoding RNAs (lncRNAs) have been demonstrated to play significant roles in hepatocellular carcinoma (HCC) tumor progression. LINC01433 has been implicated in the progression of lung cancer. However, its biological role in HCC remains poorly understood. In our current study, we focused on the detailed mechanism of LINC01433 in HCC development. First, it was exhibited that LINC01433 was remarkably elevated in HCC cells, which indicated that LINC01433 was involved in HCC. Then, knockdown of LINC01433 was able to restrain HCC cell proliferation and cell colony formation and greatly induced cell apoptosis. On the contrary, overexpression of LINC01433 promoted HCC cell proliferation, increased cell colony formation, and enhanced cell invasion capacity. Subsequently, we found that miR-1301 was remarkably decreased in HCC cells, and it can serve as a target of LINC01433 according to bioinformatics analysis. In addition, the binding correlation between them was validated by performing RNA pull-down experiments and RIP assay. Moreover, STAT3 was predicted and validated as a target of miR-1301, and it was shown that miR-1301 mimics significantly suppressed STAT3 in HCC cells.Finally, in vivo models were established, and the results demonstrated that silencing of LINC01433 could repress HCC development through modulating miR-1301 and STAT3. Taken together, these results indicated in our study that LINC01433 participated in HCC progression through modulating the miR-1301/STAT3 axis and it might act as a novel biomarker in HCC diagnosis and treatment.

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Long non‐coding RNA linc01433 promotes migration and invasion in non‐small cell lung cancer

Cited by 20 publications

References 49 publications

Expression Analysis of the Long Non-Coding RNA LINC01433 in Lung Cancer

Expression Analysis of the Long Non-Coding RNA LINC01433 in Lung Cancer

Role of long non‐coding RNA in drug resistance in non‐small cell lung cancer

LINC01433 promotes hepatocellular carcinoma progression via modulating the miR‐1301/STAT3 axis

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