Long Non-Coding RNA in Esophageal Cancer: A Review of Research Progress

Yang, Chenbo; Chen, Kuisheng

doi:10.3389/pore.2022.1610140

Cited by 17 publications

(15 citation statements)

References 90 publications

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“…Third, by guiding the relevant RNA-binding proteins, lncRNAs are able to mediate the target genes via cis- or trans-regulation to specific protein complex sites [ 33 , 34 ]. Fourth, scaffolds, lncRNAs can be used as a platform; on this platform, a variety of related molecular complexes can be combined together to enhance the information transmission and interaction between molecular complexes [ 35 , 36 ]. Studies have found that the growth and development of the body, the occurrence and development of tumors, cell proliferation, and apoptosis are all related to the abnormal expression of lncRNAs, especially in tumorigenesis [ 37 ].…”

Section: Discussionmentioning

confidence: 99%

lncRNA AGAP2-AS1 Facilitates Tumorigenesis and Ferroptosis Resistance through SLC7A11 by IGF2BP2 Pathway in Melanoma

Huang

et al. 2022

Computational and Mathematical Methods in Medicine

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Long noncoding RNAs (lncRNAs) stand as indispensable regulators of initiation and development in melanoma (melanoma). However, the action molecular mechanisms linked to melanoma remain unclear. In the current study, the findings revealed that AGAP2-AS1 was considerably greater in melanoma than in healthy tissues and that the level of AGAP2-AS1 in cancer tissue was significantly linked to the cancerous TNM stage of patients. Individuals with high AGAP2-AS1 had a considerably shorter survival duration than patients with low AGAP2-AS1, regardless of progression-free survival or overall survival. Functionally, downregulating the expression of AGAP2-AS1 can inhibit the growth of melanocytes. Compared with the control group, AGAP2-AS1 knockdown increased Erastin-mediated iron death in melanoma cells. However, iron death inhibitor FERSINT-1 restored this effect, while Erastin induced melanoma cell death. Besides, intracellular iron and Fe2+ levels increased after AGAP2-AS1 knockdown in melanoma cells treated with Erastin compared with the si-NC group. In addition, AGAP2-AS1 silencing resulted in a significant decrease in glutathione (GSH) content in Erastin-treated melanoma cells. The mechanistic results suggest AGAP2-AS1 increases SLC7A11 mRNA stability through the IGF2BP2 pathway. In this investigation, we discovered new activities for AGAP2-AS1 and firstly discovered its mechanistic basis in ferroptosis and melanoma formation that might help in the search for potential therapy options in melanoma.

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Section: Discussionmentioning

confidence: 99%

lncRNA AGAP2-AS1 Facilitates Tumorigenesis and Ferroptosis Resistance through SLC7A11 by IGF2BP2 Pathway in Melanoma

Huang

et al. 2022

Computational and Mathematical Methods in Medicine

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“…LncRNAs are mainly transcribed by RNA polymerase II, typically by a 5′7-methylguanosine cap and a 3′ poly (A) tail. Similar to messenger RNAs, they are involved in the pathogenesis of cancer [ 11 , 13 , 14 , 15 , 16 , 17 , 18 ]. Different classes of lncRNAs are generated from introns, exons, intergenic regions, telomerases, enhancers, or promoters [ 19 ].…”

Section: Long Non-coding Rnas and Potential Therapeutic Targeting In ...mentioning

confidence: 99%

The Regulatory Functions and the Mechanisms of Long Non-Coding RNAs in Cervical Cancer

Yang

Al-Hendy

2022

Cells

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Cervical cancer is one of the leading causes of death in gynecology cancer worldwide. High-risk human papillomaviruses (HPVs) are the major etiological agents for cervical cancer. Still, other factors also contribute to cervical cancer development because these cancers commonly arise decades after initial exposure to HPV. So far, the molecular mechanisms underlying the pathogenesis of cervical cancer are still quite limited, and a knowledge gap needs to be filled to help develop novel strategies that will ultimately facilitate the development of therapies and improve cervical cancer patient outcomes. Long non-coding RNAs (lncRNAs) have been increasingly shown to be involved in gene regulation, and the relevant role of lncRNAs in cervical cancer has recently been investigated. In this review, we summarize the recent progress of ascertaining the biological functions of lncRNAs in cervical cancer, from the perspective of cervical cancer proliferation, invasion, and metastasis. In addition, we provide the current state of knowledge by discussing the molecular mechanisms underlying the regulation and emerging role of lncRNAs in the pathogenesis of cervical cancer. Comprehensive and deeper insights into lncRNA-mediated alterations and interactions in cellular events will help develop novel strategies to treat patients with cervical cancer.

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“…It plays an important role in the occurrence, development and metastasis of various cancers, [6,7] and could act as biomarkers for early diagnosis and prognosis evaluation of EC. [8,9] Recently, it has been reported that 11 CRs were selected to construct a prognostic signature, which could effectively predict the outcome of bladder cancer patients. [10] However, the relationship between CRs-related lncRNAs and EC has never been researched.…”

Section: Introductionmentioning

confidence: 99%

A novel prognosis prediction of esophageal cancer based on chromatin regulator-related lncRNA

et al. 2023

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It has been reported that chromatin regulators (CRs), as one of the essential upstream regulators of tumor development, were screened to construct a prognostic model for predicting the outcome of tumor patients. However, the prognostic model based on CRs-related long noncoding RNAs (lncRNAs) in esophageal cancer (EC) has never been researched. This study aims to construct a novel CRs-related lncRNA signature to evaluate the prognostic ability of EC patients. We obtained the transcriptome data and clinical information of patients with EC from the Cancer Genome Atlas database, 870 CRs-related genes from previous topic research. Univariate, multivariate Cox, the least absolute shrinkage and selection operator regression analyses were used to establish the risk model. The receiver operating characteristic curve, principal component analysis, nomogram, quantitative real-time PCR were performed to evaluate the independence and accuracy of the model. The biological functions and immune microenvironment of the risk model were analyzed by gene set enrichment analyses and R softwares. A novel 3 CRs-related lncRNAs risk model composed of AC079684.1, TMEM75, LINC00365, as an independent and superior factor, was established for prognosis prediction of EC patients. Quantitative real-time PCR analysis verified upregulated AC079684.1 and TMEM75 mRNA levels and downregulated LINC00365 mRNA level in EC tissues compared with normal tissues. Gene set enrichment analysis analysis displayed Kyoto encyclopedia of genes and genomes and gene ontology pathways enriched in risk groups, such as focal adhesion, pathways in cancer, epidermal cell differentiation. Immune cells and immune checkpoints were more likely to be activated in the high-risk group. Finally, we found most of the compounds in the high-risk group exhibited higher sensitivity through therapeutic drug screening. The 3 CRs-related lncRNAs risk model could independently predict the prognosis of EC and provide immunotherapy guidance for patients with EC.

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Long Non-Coding RNA in Esophageal Cancer: A Review of Research Progress

Cited by 17 publications

References 90 publications

lncRNA AGAP2-AS1 Facilitates Tumorigenesis and Ferroptosis Resistance through SLC7A11 by IGF2BP2 Pathway in Melanoma

lncRNA AGAP2-AS1 Facilitates Tumorigenesis and Ferroptosis Resistance through SLC7A11 by IGF2BP2 Pathway in Melanoma

The Regulatory Functions and the Mechanisms of Long Non-Coding RNAs in Cervical Cancer

A novel prognosis prediction of esophageal cancer based on chromatin regulator-related lncRNA

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