lncRNA AGAP2-AS1 Facilitates Tumorigenesis and Ferroptosis Resistance through SLC7A11 by IGF2BP2 Pathway in Melanoma

An, Lifeng; Huang, Jingwen; Ge, Shenguang; Zhang, Xin; Wang, Jing

doi:10.1155/2022/1972516

Cited by 11 publications

(10 citation statements)

References 37 publications

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“…For instance, An et al reported that AGAP2-AS1 was significantly higher in melanoma than in healthy tissues, and the researchers found that the level of AGAP2-AS1 in cancer tissues was significantly connected to the TNM stage of the patient's malignancy. Individuals who had a high level of AGAP2-AS1 had a survival duration that was noticeably lower than that of patients who had a low level of AGAP2-AS1, and this was true for both progression-free survival and overall survival [ 31 ]. In melanoma, inhibiting the expression of the long noncoding RNA AGAP2-AS1 has the functional effect of reducing carcinogenesis and ferroptosis resistance via the SLC7A11-IGF2BP2 pathway.…”

Section: Discussionmentioning

confidence: 99%

Long Noncoding RNA LINC02249 Is a Prognostic Biomarker and Correlates with Immunosuppressive Microenvironment in Skin Cutaneous Melanoma

Han

Shen

et al. 2022

Journal of Oncology

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Skin cutaneous melanoma (SKCM) is one of the most aggressive and life-threatening tumors. It has a high incidence rate, as well as significant metastasis and fatality rates. To successfully treat SKCM and to increase the overall survival rate, early identification and risk stratification are both absolutely necessary. Long noncoding RNAs (lncRNAs) play a significant regulatory role in a variety of cancers. However, the expression and function of many lncRNAs have not been investigated. We evaluated the expression profile of the long noncoding RNA LINC02249 (LINC02249) in pan-cancers by using data on gene expression obtained from TCGA and GTEx. The biological function of LINC02249 was determined by gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG). The prognostic value of LINC02249 expression in SKCM patients was statistically analyzed. Besides, the ssGSEA approach was utilized in order to investigate the degree to which LINC02249 expression is correlated with tumor immune infiltration. In this study, the expression of LINC02249 was found to be abnormally high in a variety of tumors, according to our findings. When compared with nontumor specimens, the level of expression of LINC02249 was shown to be significantly elevated in SKCM samples. GO and KEGG assays revealed LINC02249 may be involved in tumor progression. High expression of LINC02249 was associated with shorter overall survival and disease-specific survival of SKCM patients. More importantly, multivariate methods revealed that LINC02249 expression was an independent prognostic factor for SKCM cases. Using ssGSEA, we found that the expression of LINC02249 was negatively associated with different tumor-infiltrating immune cells, especially aDC, Treg, and macrophages. Overall, our findings suggested that LINC02249 can serve as a novel biomarker to predict the prognosis and immune infiltration in SKCM.

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Section: Discussionmentioning

confidence: 99%

Long Noncoding RNA LINC02249 Is a Prognostic Biomarker and Correlates with Immunosuppressive Microenvironment in Skin Cutaneous Melanoma

Han

Shen

et al. 2022

Journal of Oncology

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“…AGAP2 antisense RNA 1 (AGAP2-AS1) is a lincRNA that was first found overexpressed in human NSCLC, being also implicated in other malignant diseases such as colorectal cancer and melanoma [161][162][163]. By interacting with specific RNA-binding proteins, namely enhancers of zeste 2 polycomb repressive complex 2 subunit (EZH2) and LSD1, some lncRNAs can regulate cell phenotypes.…”

Section: Agap2-as1mentioning

confidence: 99%

Long Non-Coding RNAs in Venous Thromboembolism: Where Do We Stand?

Marques

Tavares

Neto

et al. 2023

IJMS

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Venous thromboembolism (VTE), a common condition in Western countries, is a cardiovascular disorder that arises due to haemostatic irregularities, which lead to thrombus generation inside veins. Even with successful treatment, the resulting disease spectrum of complications considerably affects the patient’s quality of life, potentially leading to death. Cumulative data indicate that long non-coding RNAs (lncRNAs) may have a role in VTE pathogenesis. However, the clinical usefulness of these RNAs as biomarkers and potential therapeutic targets for VTE management is yet unclear. Thus, this article reviewed the emerging evidence on lncRNAs associated with VTE and with the activity of the coagulation system, which has a central role in disease pathogenesis. Until now, ten lncRNAs have been implicated in VTE pathogenesis, among which MALAT1 is the one with more evidence. Meanwhile, five lncRNAs have been reported to affect the expression of TFPI2, an important anticoagulant protein, but none with a described role in VTE development. More investigation in this field is needed as lncRNAs may help dissect VTE pathways, aiding in disease prediction, prevention and treatment.

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“…These findings reveal the important role of miRNA in regulating ferroptosis in MM. Increased expression of the lncRNA AGAP2-AS1 promotes tumorigenesis by promoting ferroptosis evasion through increased SLC7A11 mRNA stability by the m 6 A modification in an IGF2BP2-dependent manner in MM ( An et al, 2022 ). AGAP2-AS1 functions as an oncogene in MM, and its increased expression is known to be significantly associated with a poor prognosis ( An et al, 2022 ).…”

Section: The Role Of Ferroptosis In Melanomamentioning

confidence: 99%

Ferroptosis as a promising therapeutic strategy for melanoma

Ta,

Jiang,

Zhang

et al. 2023

Front. Pharmacol.

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Malignant melanoma (MM) is the most common and deadliest type of skin cancer and is associated with high mortality rates across all races and ethnicities. Although present treatment options combined with surgery provide short-term clinical benefit in patients and early diagnosis of non-metastatic MM significantly increases the probability of survival, no efficacious treatments are available for MM. The etiology and pathogenesis of MM are complex. Acquired drug resistance is associated with a pool prognosis in patients with advanced-stage MM. Thus, these patients require new therapeutic strategies to improve their treatment response and prognosis. Multiple studies have revealed that ferroptosis, a non-apoptotic form of regulated cell death (RCD) characterized by iron dependant lipid peroxidation, can prevent the development of MM. Recent studies have indicated that targeting ferroptosis is a promising treatment strategy for MM. This review article summarizes the core mechanisms underlying the development of ferroptosis in MM cells and its potential role as a therapeutic target in MM. We emphasize the emerging types of small molecules inducing ferroptosis pathways by boosting the antitumor activity of BRAFi and immunotherapy and uncover their beneficial effects to treat MM. We also summarize the application of nanosensitizer-mediated unique dynamic therapeutic strategies and ferroptosis-based nanodrug targeting strategies as therapeutic options for MM. This review suggests that pharmacological induction of ferroptosis may be a potential therapeutic target for MM.

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lncRNA AGAP2-AS1 Facilitates Tumorigenesis and Ferroptosis Resistance through SLC7A11 by IGF2BP2 Pathway in Melanoma

Cited by 11 publications

References 37 publications

Long Noncoding RNA LINC02249 Is a Prognostic Biomarker and Correlates with Immunosuppressive Microenvironment in Skin Cutaneous Melanoma

Long Noncoding RNA LINC02249 Is a Prognostic Biomarker and Correlates with Immunosuppressive Microenvironment in Skin Cutaneous Melanoma

Long Non-Coding RNAs in Venous Thromboembolism: Where Do We Stand?

Ferroptosis as a promising therapeutic strategy for melanoma

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