Long non‑coding RNA HOX transcript antisense RNA promotes expression of 14‑3‑3σ in non‑small cell lung cancer

Wang, Ranran; Yan, Bin; Zheng, Li; Jiang, Yiqun; Mao, Chao; Wei, Xiang; Zhou, Xinmin

doi:10.3892/etm.2017.5041

Cited by 14 publications

(11 citation statements)

References 24 publications

(34 reference statements)

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“…Moreover, HOTAIR can inhibit JUN and CDKN1A [221]. Furthermore, in NSCLC tumors tissues and PC9 cell line, HOTAIR can activate WNT3A, CTNNB1, APC, ABCC1, and ABCB1, and can also promote the expression of 14-3-3σ (SFN) [222,223]. In NSCLC tumor tissues and A459 cell line, HOTAIR would also upregulate CSC-related biomarkers such as NANOG, POU5F1, SOX2, MYC, CTNNB1, and KLF4 [113].…”

Section: Hotair and Lung Cancermentioning

confidence: 99%

Exosomal Long Non-Coding RNAs in Lung Diseases

Poulet

Njock

Moermans

et al. 2020

IJMS

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Within the non-coding genome landscape, long non-coding RNAs (lncRNAs) and their secretion within exosomes are a window that could further explain the regulation, the sustaining, and the spread of lung diseases. We present here a compilation of the current knowledge on lncRNAs commonly found in Chronic Obstructive Pulmonary Disease (COPD), asthma, Idiopathic Pulmonary Fibrosis (IPF), or lung cancers. We built interaction networks describing the mechanisms of action for COPD, asthma, and IPF, as well as private networks for H19, MALAT1, MEG3, FENDRR, CDKN2B-AS1, TUG1, HOTAIR, and GAS5 lncRNAs in lung cancers. We identified five signaling pathways targeted by these eight lncRNAs over the lung diseases mentioned above. These lncRNAs were involved in ten treatment resistances in lung cancers, with HOTAIR being itself described in seven resistances. Besides, five of them were previously described as promising biomarkers for the diagnosis and prognosis of asthma, COPD, and lung cancers. Additionally, we describe the exosomal-based studies on H19, MALAT1, HOTAIR, GAS5, UCA1, lnc-MMP2-2, GAPLINC, TBILA, AGAP2-AS1, and SOX2-OT. This review concludes on the need for additional studies describing the lncRNA mechanisms of action and confirming their potential as biomarkers, as well as their involvement in resistance to treatment, especially in non-cancerous lung diseases.

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Section: Hotair and Lung Cancermentioning

confidence: 99%

Exosomal Long Non-Coding RNAs in Lung Diseases

Poulet

Njock

Moermans

et al. 2020

IJMS

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“…Long non-coding RNA (lncRNA) is a class of noncoding RNA molecules containing > 200 nucleotides and regulating gene expression through a variety of mechanisms, including chromatin remodeling, regulation of gene expression on transcriptional, post-transcriptional, translational, and post-translational level, modulation of other RNA species such as microRNA, and generation of small interfering RNA (Fang and Fullwood, 2016). Functionally, lncRNA critically regulates the pathogenesis of human diseases, including tumorigenesis and cancer progression (Chen et al, 2017;Dou et al, 2017;Qian et al, 2017;Wang et al, 2017;Zuo et al, 2017). The differentiation antagonizing non-protein coding RNA (DANCR) is a newly identified lncRNA dysregulated and presenting multiple oncogenic activities in many human cancers (Thin et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

The long non‐coding RNA DANCR regulates the inflammatory phenotype of breast cancer cells and promotes breast cancer progression via EZH2‐dependent suppression of SOCS3 transcription

2020

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Long non‐coding RNA (lncRNA) is involved in the regulation of tumorigenesis and metastasis. In this study, we focused on the clinical relevance, biological effects, and molecular mechanisms of the lncRNA differentiation antagonizing non‐protein coding RNA (DANCR) in breast cancer. We compared the expression of DANCR between breast cancer and normal tissues, and between breast cancer cell lines and normal breast epithelial cells using quantitative real‐time PCR (qRT‐PCR) analysis. By knocking down and overexpressing DANCR, we assessed its significance in regulating viability (MTT assay), migration/invasion (Transwell assay), epithelial‐mesenchymal transition (western blot), stemness (mammosphere formation assay and western blot), and production of inflammatory cytokines (qRT‐PCR and ELISA) of breast cancer cells in vitro, as well as xenograft growth in vivo. Furthermore, using ChIP and RNA immunoprecipitation, we examined the reciprocal regulation between DANCR and suppressor of cytokine signaling 3 (SOCS3) in breast cancer. DANCR was significantly up‐regulated in tissue samples from patients with breast cancer, as well as in breast cancer cell lines, as compared with normal tissues and breast epithelial cells, respectively. The highest DANCR expression levels were associated with advanced tumor grades or lymph node metastasis. DANCR was necessary and sufficient to control multiple malignant phenotypes of breast cancer cells in vitro and xenograft growth in vivo. Mechanistically, DANCR promoted the binding of enhancer of zeste homolog 2 (EZH2) to the promoter of SOCS3, thereby epigenetically inhibiting SOCS3 expression. Functionally, SOCS3 up‐regulation or EZH2 inhibition could rescue multiple malignant phenotypes induced by DANCR. Our data indicate that DANCR is a pleiotropic oncogenic lncRNA in breast cancer. Boosting SOCS3 expression may reverse the oncogenic activities of DANCR and thus provide a therapeutic strategy for breast cancer treatment.

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“…Studies have shown that HOTAIR is highly expressed in non-small cell lung cancer (NSCLC) relative to that in normal lung tissues, and is involved in cell migration, growth, invasion, and metastasis [21][22][23][24][25]. Aberrant HOTAIR expression is correlated with metastasis and poor prognosis; in addition, it is considered a potential biomarker for patients with NSCLC.…”

Section: Hotair In Lung Cancermentioning

confidence: 99%

HOTAIR: An Oncogenic Long Non-Coding RNA in Human Cancer

Tang

Hann

2018

Cell Physiol Biochem

213

135

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Long non-coding RNAs (LncRNAs) represent a novel class of noncoding RNAs that are longer than 200 nucleotides without protein-coding potential and function as novel master regulators in various human diseases, including cancer. Accumulating evidence shows that lncRNAs are dysregulated and implicated in various aspects of cellular homeostasis, such as proliferation, apoptosis, mobility, invasion, metastasis, chromatin remodeling, gene transcription, and post-transcriptional processing. However, the mechanisms by which lncRNAs regulate various biological functions in human diseases have yet to be determined. HOX antisense intergenic RNA (HOTAIR) is a recently discovered lncRNA and plays a critical role in various areas of cancer, such as proliferation, survival, migration, drug resistance, and genomic stability. In this review, we briefly introduce the concept, identification, and biological functions of HOTAIR. We then describe the involvement of HOTAIR that has been associated with tumorigenesis, growth, invasion, cancer stem cell differentiation, metastasis, and drug resistance in cancer. We also discuss emerging insights into the role of HOTAIR as potential biomarkers and therapeutic targets for novel treatment paradigms in cancer.

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Long non‑coding RNA HOX transcript antisense RNA promotes expression of 14‑3‑3σ in non‑small cell lung cancer

Abstract: Abstract. Evidence suggests that both 14-

Cited by 14 publications

References 24 publications

Exosomal Long Non-Coding RNAs in Lung Diseases

Exosomal Long Non-Coding RNAs in Lung Diseases

The long non‐coding RNA DANCR regulates the inflammatory phenotype of breast cancer cells and promotes breast cancer progression via EZH2‐dependent suppression of SOCS3 transcription

HOTAIR: An Oncogenic Long Non-Coding RNA in Human Cancer

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