Long Non-Coding RNA Expression Profiles for the Characterization of Different Bladder Cancer Grade

Cao, Yuepeng; Zhou, Jun; Li, Weijian; Shao, Yang; Tian, Tian; Xie, Kaipeng; Yan, Xiang

doi:10.1159/000494542

Cited by 11 publications

(9 citation statements)

References 32 publications

(32 reference statements)

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“…LncRNAs regulate gene expression at the post-transcriptional level, including protein synthesis, RNA maturation, and transport (8). Previous studies report that lncRNAs play a role in tumorigenesis and metastasis in different cancer types (3,(9)(10)(11)(12). Several lncRNAs are reported to play important roles in the progression and invasion of bladder cancer.…”

Section: Introductionmentioning

confidence: 99%

RETRACTED: Long Noncoding RNA SNHG1 Activates Autophagy and Promotes Cell Invasion in Bladder Cancer

Guo

Xie

et al. 2021

Front. Oncol.

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LncRNAs play important roles in bladder cancer. However, only a few studies report on the correlation between lncRNAs expression and autophagy in bladder cancer. This study aimed to explore the effect of lncRNA on autophagy in bladder cancer. The findings showed high expression of SNHG1 in the bladder cancer cells and tumor tissues. The high expression of SNHG1 was positively correlated with bladder cancer cell invasion, proliferation, and autophagy. This finding implies that SNHG1 promotes bladder cancer cell invasion and proliferation via autophagy. Further analysis of the mechanism of action of SNHG1 showed that it functions as a sponge of miRNA-493 in bladder cancer. miRNA-493 binds on the 3’ -UTR of ATG14 mRNA thus affecting ATG14 protein expression, which is implicated in autophagy. These findings are supported by previous preclinical studies using multiple Bca cell lines and TCGA, which demonstrate that SNHG1 plays an oncogenic role by acting as a sponge of miR-493-5p or as its ceRNA. Upregulation of SNHG1 promotes proliferation, invasion, and autophagy of bladder cancer cells through the miR-493-5p/ATG14/autophagy pathway. Therefore, SNHG1 may act as a potential therapeutic target for the treatment of bladder cancer.

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Section: Introductionmentioning

confidence: 99%

RETRACTED: Long Noncoding RNA SNHG1 Activates Autophagy and Promotes Cell Invasion in Bladder Cancer

Guo

Xie

et al. 2021

Front. Oncol.

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“…In addition to the latter our analysis also revealed lncRNAs ( DLX6-AS1 ) that regulate the expression of distant mRNAs ( DLX6-AS1 ) 26,27 . Interestingly, previous brain related studies have also found some of our top DE lncRNAs, LBX2-AS1 28 and LUCAT1 29,30 as significantly co-expressed with other mRNAs expressed in brain (Fig. 1c).…”

Section: Resultssupporting

confidence: 61%

Transcriptome-wide Profiling of Cerebral Cavernous Malformations Patients Reveal Important Long noncoding RNA molecular signatures

Subhash

Kalmbach

Wegner

et al. 2019

Sci Rep

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Cerebral cavernous malformations (CCMs) are low-flow vascular malformations in the brain associated with recurrent hemorrhage and seizures. The current treatment of CCMs relies solely on surgical intervention. Henceforth, alternative non-invasive therapies are urgently needed to help prevent subsequent hemorrhagic episodes. Long non-coding RNAs (lncRNAs) belong to the class of non-coding RNAs and are known to regulate gene transcription and involved in chromatin remodeling via various mechanism. Despite accumulating evidence demonstrating the role of lncRNAs in cerebrovascular disorders, their identification in CCMs pathology remains unknown. The objective of the current study was to identify lncRNAs associated with CCMs pathogenesis using patient cohorts having 10 CCM patients and 4 controls from brain. Executing next generation sequencing, we performed whole transcriptome sequencing (RNA-seq) analysis and identified 1,967 lncRNAs and 4,928 protein coding genes (PCGs) to be differentially expressed in CCMs patients. Among these, we selected top 6 differentially expressed lncRNAs each having significant correlative expression with more than 100 differentially expressed PCGs. The differential expression status of the top lncRNAs, SMIM25 and LBX2-AS1 in CCMs was further confirmed by qRT-PCR analysis. Additionally, gene set enrichment analysis of correlated PCGs revealed critical pathways related to vascular signaling and important biological processes relevant to CCMs pathophysiology. Here, by transcriptome-wide approach we demonstrate that lncRNAs are prevalent in CCMs disease and are likely to play critical roles in regulating important signaling pathways involved in the disease progression. We believe, that detailed future investigations on this set of identified lncRNAs can provide useful insights into the biology and, ultimately, contribute in preventing this debilitating disease.

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“…Furthermore, LUCAT1 also acts on esophageal squamous cell carcinoma where it regulates the stability of DNMT1 leading to the formation and metastasis of this carcinoma 28 . LUCAT1 and CCNB1 had a positive relationship in regulating the progress of bladder cancer 29 . It was also found to present a differential expression on head and neck squamous cell carcinoma, together with other lncRNAs 30 and it exerts an oncogenic function in cervical cancer by binding to miR-181a 31 .…”

Section: Introductionmentioning

confidence: 92%

LncRNA LUCAT1 as a novel prognostic biomarker for patients with papillary thyroid cancer

Lasa

Fernández

Martos-Martínez

et al. 2019

Sci Rep

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In recent years, long non-coding RNAs have emerged as a novel class of regulators of cancer biological processes. While they are dysregulated in many cancer types, little is known about their expression and functional profiles. This study has been focused on the determination of the role of a specific lncRNA in papillary thyroid cancer. Quantitative reverse transcription PCR was performed to detect the expression levels of 84 lncRNAs in 61 papillary thyroid carcinoma tissues and their adjacent non-tumor tissues. The highest fold-change was obtained for lung cancer associated transcript 1 LUCAT1, and thus, this study determines the expression and biological implication of lncRNA LUCAT1 through different in vitro and ex vivo approaches in this tumor. LUCAT1 was specifically located at the cell nucleus in tumoral regions of patient tissues. Furthermore, LUCAT1 knockdown significantly reduced both cell proliferation and invasion ex vivo and induced cell-cycle arrest and apoptosis. These facts were corroborated by an enhanced expression of P21, P57, P53 and BAX, and a reduced expression of EZH2 and HDAC1. In addition, a significant decrease was observed on DNMT1 and NRF2 genes, helping to clarify the role of LUCAT1 on PTC. Our study reveals the involvement of LUCAT1 in PTC development, through acting in cell-cycle regulation, proliferation, epigenetic modifications through LUCAT1/ CDK1/ EZH2/ P57/ P21/ HDAC1/ DNMT1/ P53/ BAX axis and apoptosis, via extrinsic pathway activating caspases. These findings indicate that LUCAT1 is maybe a potential therapeutic target and molecular biomarker for PTC.

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Long Non-Coding RNA Expression Profiles for the Characterization of Different Bladder Cancer Grade

Cited by 11 publications

References 32 publications

RETRACTED: Long Noncoding RNA SNHG1 Activates Autophagy and Promotes Cell Invasion in Bladder Cancer

RETRACTED: Long Noncoding RNA SNHG1 Activates Autophagy and Promotes Cell Invasion in Bladder Cancer

Transcriptome-wide Profiling of Cerebral Cavernous Malformations Patients Reveal Important Long noncoding RNA molecular signatures

LncRNA LUCAT1 as a novel prognostic biomarker for patients with papillary thyroid cancer

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