2019
DOI: 10.1038/s41598-019-50913-7
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Abstract: In recent years, long non-coding RNAs have emerged as a novel class of regulators of cancer biological processes. While they are dysregulated in many cancer types, little is known about their expression and functional profiles. This study has been focused on the determination of the role of a specific lncRNA in papillary thyroid cancer. Quantitative reverse transcription PCR was performed to detect the expression levels of 84 lncRNAs in 61 papillary thyroid carcinoma tissues and their adjacent non-tumor tissue… Show more

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Cited by 43 publications
(26 citation statements)
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“…It has been proved to be closely related to many tumor diseases [9,10]. LncRNA LUCAT1 has been proved to be involved in ovarian cancer and thyroid carcinoma [11,12] in previous studies, but its role in CC is still unclear. We speculated that LUCAT1 might be closely related to the occurrence of CC.…”
Section: Introductionmentioning
confidence: 99%
“…It has been proved to be closely related to many tumor diseases [9,10]. LncRNA LUCAT1 has been proved to be involved in ovarian cancer and thyroid carcinoma [11,12] in previous studies, but its role in CC is still unclear. We speculated that LUCAT1 might be closely related to the occurrence of CC.…”
Section: Introductionmentioning
confidence: 99%
“…LUCAT1 (Ensembl: ENSG00000248323) was suggested as a potential prognostic biomarker for PTC patients. 13 But its exact functions on TC cell behaviors and the molecular mechanisms are largely unknown. Here, we first determined expression of LUCAT1 in the collected tumor and normal samples from 47 patients.…”
Section: Resultsmentioning
confidence: 99%
“… 11 , 12 It was suggested as a potential prognostic biomarker for patients with PTC. 13 But its exact function on TC progression remains largely unknown. 11 Importantly, data on a bioinformatics system ( http://starbase.sysu.edu.cn/ ) suggested miR-493 as a sponge for LUCAT1, while a disintegrin and metalloproteinase-10 (ADAM10) was suggested as a target mRNA of miR-493.…”
Section: Introductionmentioning
confidence: 99%
“…Another limitation is that, at this point, we have only confirmed the group of lncRNAs through performing a qRT-PCR. Thus, different further studies should be made to validate the obtained results, such as in situ hybridization to detect differences of lncRNA expression among normal and tumoral adjacent part of the tumour, studies in cell lines of MTC, such as TT cells (invasion, proliferation, silencing/overexpression of lncRNA target, apoptosis, cell cycle assays …) [ 8 , 40 ].…”
Section: Discussionmentioning
confidence: 99%