Long non‐coding RNA CASC7 is associated with the pathogenesis of heart failure via modulating the expression of miR‐30c

Xu, Yu; Liu, Yang; Cai, Ruping; He, Shirong; Dai, Rixin; Yang, Xiheng; Kong, Biao; Qin, Zhenbai; Su, Qiang

doi:10.1111/jcmm.15764

Cited by 17 publications

(15 citation statements)

References 44 publications

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“…Previous studies have confirmed that lncRNAs could act as sponges to regulate miRNAs ( 38 – 40 ). It was found that MIR22HG contained a potential binding site for miR-9 using the bioinformatics database StarBase v2.0 ( Fig.…”

Section: Resultsmentioning

confidence: 86%

Long non‑coding RNA MIR22HG inhibits glioma progression by downregulating microRNA‑9/CPEB3

Nan

Yan

et al. 2020

Oncol Lett

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Glioma is one of the most common and aggressive malignant intracranial tumors worldwide. Recently, non-coding RNAs have been found to play critical roles in the development of glioma. However, the exact mechanisms have not been fully elucidated. In the present study, reverse transcription-quantitative PCR was used to determine the expression level of the long non-coding RNA MIR22HG and microRNA (miR)-9, while western blot analysis was used to detect the protein expression level of CPEB3. The potential binding sites were predicted using the StarBase v2.0 online tool and the hypothesis was verified using a luciferase reporter assay. A Cell Counting Kit-8 assay was used to assess cell viability, while wound healing and Matrigel assays were used to determine the migration and invasion ability of glioma cancer cells. The results showed that MIR22HG expression level was decreased but miR-9 expression level was elevated in glioma tissues and cell lines. Furthermore, MIR22HG was found to sponge miR-9, while CPEB3 was the direct target of miR-9 in the glioma cell line. Functionally, MIR22HG regulated the proliferation, invasion and migration of the glioma cell line by targeting miR-9. CPEB3 may be involved in the progression of the glioma cell line. Taken together, these findings confirmed that MIR22HG suppressed glioma development by inhibiting the miR-9/CPEB3 axis and provides a novel therapeutic strategy for glioma treatment.

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Section: Resultsmentioning

confidence: 86%

Long non‑coding RNA MIR22HG inhibits glioma progression by downregulating microRNA‑9/CPEB3

Nan

Yan

et al. 2020

Oncol Lett

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“…The included studies were published between 2007 and 2021. Twenty-three studies were conducted in China [ 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 ]; ten in the United States [ 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 ]; five in Iran [ 47 , 48 , 49 , 50 , 51 ]; four in Italy [ 52 , 53 , 54 , 55 ]; three in the Netherlands [ 56 , 57 , 58 ]; three in Germany [ 59 , 60 , 61 ]; two in Taiwan [ 62 , 63 ]; two in Australia [ 64 , 65 ]; and one each in New Zealand [ 66 …”

Section: Resultsmentioning

confidence: 99%

“…The included studies assessed different genetic components. Twenty-four studies involved the assessment of single-nucleotide polymorphism (SNP) [ 18 , 19 , 20 , 21 , 26 , 28 , 33 , 39 , 40 , 42 , 43 , 45 , 47 , 48 , 49 , 50 , 51 , 52 , 62 , 63 , 67 , 69 , 72 , 74 ], eight studies were on the transcriptome [ 23 , 29 , 36 , 41 , 46 , 54 , 61 , 71 ], twenty-three studied microRNA (miRNA) [ 14 , 15 , 16 , 22 , 23 , 24 , 29 , 30 , 31 , 32 , 37 , 38 , 44 , 55 , 56 , 57 , 58 , 61 , 65 , 66 , 68 , …”

Section: Resultsmentioning

confidence: 99%

“…Nine of the included studies reported the regulation of lncRNA in HF patients [ 23 , 29 , 31 , 34 , 36 , 41 , 53 , 54 , 59 ]. Four studies involved the examination of lncRNA in cardiac tissue, one study in EAT and one in PBMCs.…”

Section: Resultsmentioning

confidence: 99%

“…Four studies involved the examination of lncRNA in cardiac tissue, one study in EAT and one in PBMCs. In six studies, the modulation of lncRNA in HF patients was validated in peripheral blood [ 23 , 29 , 31 , 34 , 53 , 59 ]. In a study conducted by Greco et al [ 53 ], 13 lncRNAs were significantly modulated (10 up- and 3 downregulated) in HF patients when compared to control subjects.…”

Section: Resultsmentioning

confidence: 99%

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Exploration of Potential Genetic Biomarkers for Heart Failure: A Systematic Review

Chan

Waye

Liu

et al. 2021

IJERPH

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Patients with heart failure (HF) often present with signs and symptoms that are often nonspecific and with a wide differential diagnosis, making diagnosis and prognosis of HF by clinical presentation alone challenging. Our knowledge on genetic diversity is rapidly evolving with high-throughput DNA sequencing technology, which makes a great potential for genetic biomarker development. The present review attempts to provide a comprehensive review on the modification of major genetic components in HF patients and to explore the potential application of these components as clinical biomarkers in the diagnosis and in monitoring the progress of HF. The literature search was conducted using six databases, resulting in the inclusion of eighteen studies in the review. The findings of these studies were summarized narratively. An appraisal of the reporting quality of the included studies was conducted using a twelve-item checklist adapted from the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) checklist. The findings showed that changes in genetic components in patients with HF compared to healthy controls could be noninvasive diagnostic or prognostic tools for HF with higher specificity and sensitivity in comparison with the traditional biomarkers. This review provided evidence for the potential of developing genetic biomarkers of HF.

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Advances in MicroRNA Therapy for Heart Failure: Clinical Trials, Preclinical Studies, and Controversies

Huang,

Zhou,

Zhang

et al. 2023

Cardiovasc Drugs Ther

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Long non‐coding RNA CASC7 is associated with the pathogenesis of heart failure via modulating the expression of miR‐30c

Abstract: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 17 publications

References 44 publications

Long non‑coding RNA MIR22HG inhibits glioma progression by downregulating microRNA‑9/CPEB3

Long non‑coding RNA MIR22HG inhibits glioma progression by downregulating microRNA‑9/CPEB3

Exploration of Potential Genetic Biomarkers for Heart Failure: A Systematic Review

Advances in MicroRNA Therapy for Heart Failure: Clinical Trials, Preclinical Studies, and Controversies

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