Advances in MicroRNA Therapy for Heart Failure: Clinical Trials, Preclinical Studies, and Controversies

Huang, Shengyuan; Zhou, Yong; Zhang, Yiru; Liu, Ningyuan; Liu, Jiachen; Liu, Liming; Fan, Chengming

doi:10.1007/s10557-023-07492-7

Cited by 2 publications

(1 citation statement)

References 89 publications

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“…Although non-coding RNA-based therapies for tendon injuries hold promise, it is essential to carefully consider and address any potential side effects and safety concerns associated with these treatments. The introduction of non-coding RNAs into the body may trigger an immune response ( Huang et al, 2023 ) and off-target effects ( Fink and Wolfe, 2011 ), leading to inflammation or other adverse reactions. Toxicity is another concern, particularly if RNAs are not effectively targeted to the affected area, potentially causing damage to healthy cells and tissues.…”

Section: Discussionmentioning

confidence: 99%

Advances in non-coding RNA in tendon injuries

Wang,

Chen,

Zou

et al. 2024

Front. Genet.

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Tendons serve as important weight-bearing structures that smoothly transfer forces from muscles to skeletal parts, allowing contracted muscle movements to be translated into corresponding joint movements. For body mechanics, tendon tissue plays an important role. If the tendons are damaged to varying degrees, it can lead to disability or pain in patients. That is to say, tendon injuries havea significant impact on quality of life and deserve our high attention. Compared to other musculoskeletal tissues, tendons are hypovascular and hypo-cellular, and therefore have a greater ability to heal, this will lead to a longer recovery period after injury or even disability, which will significantly affect the quality of life. There are many causes of tendon injury, including trauma, genetic factors, inflammation, aging, and long-term overuse, and the study of related mechanisms is of great significance. Currently, tendon there are different treatment modalities, like injection therapy and surgical interventions. However, they have a high failure rate due to different reasons, among which the formation of adhesions severely weakens the tissue strength, affecting the functional recovery and the patient’s quality of life. A large amount of data has shown that non coding RNAs can play a huge role in this field, thus attracting widespread attention from researchers from various countries. This review summarizes the relevant research progress on non-coding RNAs in tendon injuries, providing new ideas for a deeper understanding of tendon injuries and exploring new diagnostic and therapeutic approaches.

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Section: Discussionmentioning

confidence: 99%

Advances in non-coding RNA in tendon injuries

Wang,

Chen,

Zou

et al. 2024

Front. Genet.

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The Double-Edged Sword of ROS in Muscle Wasting and COPD: Insights from Aging-Related Sarcopenia

Chan,

Selemidis,

Vlahos

2024

Antioxidants

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An elevation in reactive oxygen species (ROS) is widely accepted to be a key mechanism that drives chronic obstructive pulmonary disease (COPD) and its major co-morbidity, skeletal muscle wasting. However, it will be perhaps a surprise to many that an elevation in ROS in skeletal muscle is also a critical process for normal skeletal muscle function and in the adaptations to physical exercise. The key message here is that ROS are not solely detrimental. This duality of ROS suggests that the mere use of a broad-acting antioxidant is destined to fail in alleviating skeletal muscle wasting in COPD because it will also be influencing critical physiological ROS-dependent processes. Here, we take a close look at this duality of ROS in skeletal muscle physiology and pathophysiology pertaining to COPD and will aim to gain critical insights from other skeletal muscle wasting conditions due to aging such as sarcopenia.

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Advances in MicroRNA Therapy for Heart Failure: Clinical Trials, Preclinical Studies, and Controversies

Cited by 2 publications

References 89 publications

Advances in non-coding RNA in tendon injuries

Advances in non-coding RNA in tendon injuries

The Double-Edged Sword of ROS in Muscle Wasting and COPD: Insights from Aging-Related Sarcopenia

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