Long non-coding ribonucleic acid H19 and ten-eleven translocation enzyme 1 messenger RNA expression levels in uterine fibroids may predict their postoperative recurrence

Abstract

To investigate the predictive value of long non-coding RNA (lncRNA) H19 and the teneleven translocation enzyme 1 (TET1) transcriptional expression in postoperative recurrence of uterine fibroids (UFs). METHODS: Seventy-five patients with UF, who underwent surgical treatment, were enrolled in the treatment group, and 60 healthy individuals were enrolled in the control group. The relative expression levels of lncRNA H19 and TET1 mRNA in the serum and UF tissues were analyzed. The patients were further divided into a better curative (BC) group and a poor efficacy (PE) group to analyze the predictive value of lncRNA H19 and TET1 and the independent risk factors affecting the recurrence of UF. RESULTS: Compared with the control group, lncRNA H19 expression levels were significantly higher, while TET1 expression levels were significantly lower in the treatment group (po0.001). The area under the receiver operating characteristic (ROC) curve (AUC) values of the two indicators for diagnostic importance were found to be 0.872 and 0.826, respectively. Compared with the PE group, lncRNA H19 expression levels were significantly lower, while TET1 expression levels were significantly higher in the BC group (po0.001). The AUC values of the two indicators for their predictive efficacy were 0.788 and 0.812, respectively. Logistic regression analysis showed that age, menarche age, maximum diameter of UFs, number of UFs, lncRNA H19 levels, and TET1 levels were independent risk factors affecting UF recurrence. The AUC values of lncRNA H19 and TET1 for their predictive value for postoperative recurrence were 0.814 and 0.765, respectively. CONCLUSIONS: The lncRNA H19 and TET1 have high diagnostic and predictive efficacy for determining the postoperative recurrence of UFs.

The role of long non-coding RNA H19 in infertility

“…Both H19 and TET1 are independent risk factors for the recurrence of UFs. In addition, they are quite effective at diagnosing and predicting the post-surgical recurrence of UFs [ 44 ]. Combined with the idea that single nucleotide polymorphisms (SNPs) of H19 are related to a growing risk of leiomyosarcoma and tumor size [ 45 , 46 ], these findings indicate an essential role for H19 in the pathogenesis of UFs.…”

A View on Uterine Leiomyoma Genesis through the Prism of Genetic, Epigenetic and Cellular Heterogeneity

“…TET3 expression in the UL also depends on sex steroid hormones and increases under combined exposure to oestrogen and progesterone [ 298 ]. Furthermore, reduced TET1 expression in UL cells is associated with the risk of tumour recurrence [ 299 ].…”