Long latent development of trophoblastic disease

S, Guvener; Kazancigil, A; Erez, Selçuk

doi:10.1016/0002-9378(72)90848-4

Cited by 9 publications

(1 citation statement)

References 7 publications

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“…Of patients assigned uncertain etiology, one was deduced GCO because of the presence of a corpus luteum [ 25 ], which can be suggestive, but not pathognomonic of gestational etiology; three patients were diagnosed with NGCO because of no intercourse in 10 years (G5P3) [ 26 ], long duration from the antecedent pregnancy(G1P1) [ 2 ], or husband’s undergoing vasectomy(G4P2) [ 27 ]. None of them can be excluded from gestational etiology since GCO has been reported to arise many years after an abortion or molar pregnancy, even in postmenopausal woman [ 28 – 31 ]. Other cases were diagnosed with NGCO simply according to pathology.…”

Section: Discussionmentioning

confidence: 99%

A gestational choriocarcinoma of the ovary diagnosed by DNA polymorphic analysis: a case report and systematic review of the literature

et al. 2017

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BackgroundChoriocarcinoma of the ovary is rare. This tumor can arise from gestational tissue or pure germ cells of the ovary, the former results in gestational choriocarcinoma. The clinical characteristics and histology of both tumor types are identical, differentiation of these tumors is necessary for effective treatment. One strategy for the differentiation of these tumors types is to identify the presence of paternal DNA by DNA polymorphic analysis.Case presentationIn the present case, a 27-year-old patient with a history of amenorrhea, lower abdominal pain and vaginal bleeding received a laparoscopic dissection of cystic mass of the right ovary according to an initial diagnosis of ectopic pregnancy. Primary choriocarcinoma of the ovary was diagnosed by pathology, but its origin was uncertain. DNA polymorphic analysis was then performed and a gestational origin was confirmed. The patient subsequently exhibited an excellent response to chemotherapy, achieved complete remission and gave birth to a healthy baby.ConclusionDifferentiation between two etiologies of primary choriocarcinoma can be achieved with DNA polymorphic analysis and it is necessary to distinguish between them to approach to an appropriate treatment of a patient.

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Section: Discussionmentioning

confidence: 99%

A gestational choriocarcinoma of the ovary diagnosed by DNA polymorphic analysis: a case report and systematic review of the literature

et al. 2017

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Pure nongestational choriocarcinoma of the ovary report of a case

Vance

Geisinger

1985

Cancer

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The authors report a case of pure nongestational choriocarcinoma of the ovary (NGCO) in a prepubertal female patient and emphasize the electron microscopic and immunohistochemical findings. Pure NGCO accounts for 0.6% or less of all ovarian neoplasms. Distinction from gestational choriocarcinoma of the ovary (GCO) is important because of the worse prognosis of NGCO. No distinctive ultrastructural or immunohistochemical differences were found between NGCO and GCO. Cytogenetic studies may be indicated in future cases to investigate potential reasons for the difference in prognosis.

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Choriocarcinoma and Placental Site Trophoblastic Tumor

Mazur¹,

Kurman²

1987

Clinical Perspectives in Obstetrics and Gynecology

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Long latent development of trophoblastic disease

Cited by 9 publications

References 7 publications

A gestational choriocarcinoma of the ovary diagnosed by DNA polymorphic analysis: a case report and systematic review of the literature

A gestational choriocarcinoma of the ovary diagnosed by DNA polymorphic analysis: a case report and systematic review of the literature

Pure nongestational choriocarcinoma of the ovary report of a case

Choriocarcinoma and Placental Site Trophoblastic Tumor

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