Pure nongestational choriocarcinoma of the ovary report of a case

Abstract

The authors report a case of pure nongestational choriocarcinoma of the ovary (NGCO) in a prepubertal female patient and emphasize the electron microscopic and immunohistochemical findings. Pure NGCO accounts for 0.6% or less of all ovarian neoplasms. Distinction from gestational choriocarcinoma of the ovary (GCO) is important because of the worse prognosis of NGCO. No distinctive ultrastructural or immunohistochemical differences were found between NGCO and GCO. Cytogenetic studies may be indicated in future cases to investigate potential reasons for the difference in prognosis.

A gestational choriocarcinoma of the ovary diagnosed by DNA polymorphic analysis: a case report and systematic review of the literature

“…Histologically, combining with other germ cell elements such as embryonal carcinoma or dysgerminoma in the tumor imply a non-gestational etiology. When sole choriocarcinoma is present, it is difficult to distinguish the etiology by routine histologic examination, even no significant ultrastructural differences are displayed between non-gestational and gestational choriocarcinoma [5]. HCG level does not distinguish between two types of tumor.…”

Choriocarcinome primitif de l'ovaire : à propos d'un cas

“…Le choriocarcinome primitif de l'ovaire est égale-ment de diagnostic très rare. Ne sont décrits que quelques cas dans la littérature, le plus souvent chez de très jeunes patientes prépubaires ou vierges [2,10,11]. Cependant, le diagnostic de choriocarcinome primitif devient extrêmement difficile en période d'activité génitale et la plupart des cas cliniques analysés ne concerne que de très fortes suspicions [12].…”

Pure nongestational ovarian choriocarcinoma: A scoping review

“…Of these, nine occurred in premenarchal females [12][13][14][15][16][17][18], 11 occurred in postmenarchal females but were confirmed by DNA analysis [18,[19][20][21][22][23][24][25], and eight were considered possible cases of pure NGOC according to the strict criteria described above in the methods section [18,[26][27][28][29][30][31][32] ( Tables 1-3).…”

“…Two cases were treated with surgical therapy alone [15]. Two cases were treated with PVB (cisplatin, bleomycin, and vinblastine) therapy [16,18]. One case was treated with vincristine, methotrexate, leukovorin, bleomycin, Adriamycin, and cyclophosphamide [14].…”

“…One patient was reported to be alive and well at ten-year follow-up [15], one patient had no evidence of disease at six-month follow-up [18], one had no evidence of disease at 17-month follow-up [19], and one had no evidence of disease at one year followup [20]. One patient died from immediate postoperative complications [15], and one patient was reported dead of disease [20].…”