Long-lasting drug delivery systems based on microneedles

Vora, Lalitkumar K.; Moffatt, Kurtis; Donnelly, Ryan F.

doi:10.1016/b978-0-12-821749-8.00010-0

Cited by 13 publications

(3 citation statements)

References 143 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the last two decades, prolonged-release injectable formulations such as implants and microspheres have gained a significant market share. These include polymeric compact tablets of steroids (Norplant®), PLGA microspheres [Lupron Depot® (leuprolide), Nutropin® (somatropin), and Risperal® Consta® (risperidone)], and preformed implants (Zoladex® implant] [45]. The limitations of microspheres and preformed implants are difficult as well as expensive manufacturing steps.…”

Section: Importance Of Lyotropic Liquid Crystalsmentioning

confidence: 99%

Lyotropic liquid crystals for parenteral drug delivery

Chavda

Dawre

Pandya

et al. 2022

Journal of Controlled Release

View full text Add to dashboard Cite

Section: Importance Of Lyotropic Liquid Crystalsmentioning

confidence: 99%

Lyotropic liquid crystals for parenteral drug delivery

Chavda

Dawre

Pandya

et al. 2022

Journal of Controlled Release

View full text Add to dashboard Cite

“…As the SC contains no nociceptors and MNs do not invade deeper where nerve endings are present, they are capable of carrying drugs to the permeable regions of skin without provoking nerves responsible for pain [7,8]. MNs can also obviate the first pass effect, which is a classic drawback of oral drug delivery, by effectively delivering drugs via the intradermal route [9,10].…”

Section: Introductionmentioning

confidence: 99%

Deferasirox Nanosuspension Loaded Dissolving Microneedles for Intradermal Delivery

et al. 2022

View full text Add to dashboard Cite

Microneedles are minimally invasive systems that can deliver drugs intradermally without pain and bleeding and can advantageously replace the hypodermal needles and oral routes of delivery. Deferasirox (DFS) is an iron chelator employed in several ailments where iron overload plays an important role in disease manifestation. In this study, DFS was formulated into a nanosuspension (NSs) through wet media milling employing PVA as a stabilizer and successfully loaded in polymeric dissolving microneedles (DMNs). The release studies for DFS-NS clearly showed a threefold increased dissolution rate compared to pure DFS. The mechanical characterization of DFS-NS-DMNs revealed that the system was sufficiently strong for efficacious skin penetration. Optical coherence tomography images confirmed an insertion of up to 378 µm into full-thickness porcine skin layers. The skin deposition studies showed 60% drug deposition from NS-DMN, which was much higher than from the DFS-NS transdermal patch (DFS-NS-TP) (without needles) or pure DFS-DMNs. Moreover, DFS-NS without DMNs did not deposit well inside the skin, indicating that DMNs played an important role in effectively delivering drugs inside the skin. Therefore, it is evident from the findings that loading DFS-NS into novel DMN devices can effectively deliver DFS transdermally.

show abstract

“…These advantages lead to the administration of lower doses through microneedle patches to achieve the optimal therapeutic effect. There are different types of MNPs such as solid microneedles, coated microneedles, dissolvable microneedles and hollow microneedles [13][14][15]. Among these, dissolvable microneedles patches (dMNPs) have recently gained widespread popularity among scientists due to their low manufacturing cost, improved immunogenicity and ease of use.…”

Section: Introductionmentioning

confidence: 99%

Simvastatin Loaded Dissolvable Microneedle Patches with Improved Pharmacokinetic Performance

Zulcaif

Zafar

Mahmood³

et al. 2022

Micromachines

View full text Add to dashboard Cite

Microneedle patches (MNPs) are one of the emerging approaches for drug delivery involving minimal invasion and improved skin penetration of macro- and micro-entities. Herein, we report dissolvable microneedle patches (dMNPs) as a novel tool for better systemic delivery of Simvastatin in the management of hypocholesteremia. Thiolated chitosan (TC), polyvinyl pyrolidone (PVP) and polyvinyl alcohol (PVA) were employed in the development of dMNPs. Developed patches were characterized through SEM, FTIR, DSC, TGA, PXRD, dissolution testing, tensile strength, elongation (%), skin irritation studies, moisture content and pharmacokinetic evaluation. dMNP F26 exhibited excellent tensile strength (9.85 MPa), penetration potential (~700µm), moisture content (5.95%), elongation (35.54%) and Simvastatin release of 77.92%. Pharmacokinetic properties were also improved, i.e., Cmax 1.97 µg/mL, tmax 9 h, MRT 19.9 h and AUC 46.24 µg.h/mL as compared to Simvastatin solution displaying Cmax 2.55 µg/mL, tmax 3 h, MRT 5.91 h and AUC 14.20 µg.h/mL thus confirming higher and improved bioavailability. Kinetic modelling revealed zero order as the best fit model based on regression coefficient. Histopathological findings proved the biocompatibility of the developed dMNPs.

show abstract

Long-lasting drug delivery systems based on microneedles

Cited by 13 publications

References 143 publications

Lyotropic liquid crystals for parenteral drug delivery

Lyotropic liquid crystals for parenteral drug delivery

Deferasirox Nanosuspension Loaded Dissolving Microneedles for Intradermal Delivery

Simvastatin Loaded Dissolvable Microneedle Patches with Improved Pharmacokinetic Performance

Contact Info

Product

Resources

About