Lyotropic liquid crystals for parenteral drug delivery

Chavda, Vivek P.; Dawre, Shilpa; Pandya, Anjali; Vora, Lalitkumar K.; Modh, Dharti; Shah, Vidhi V.; Dave, Divyang; Patravale, Vandana

doi:10.1016/j.jconrel.2022.06.062

Cited by 40 publications

(11 citation statements)

References 197 publications

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“…Q phases of LLCs are particularly attractive as the hydrophobic and hydrophilic channels are continuous in all directions, eliminating the daunting task of aligning nanoscale channels. Furthermore, Q structures are found in biological systems and have several technical applications such as drug delivery, , controlled chemical reactions, and nanofiltration. , The tunability of the bilayer curvature in the Q phase is also exploited in designing cubosomes intended for drug delivery applications.…”

Section: Discussionmentioning

confidence: 99%

Obtaining and Characterizing Stable Bicontinuous Cubic Morphologies and Their Nanochannels in Lyotropic Liquid Crystal Membranes

et al. 2022

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Amphiphilic monomers in polar solvents can self-assemble into lyotropic liquid crystal (LLC) bicontinuous cubic structures under the right composition and temperature conditions. After cross-linking, the resulting polymer membranes with three-dimensional (3D) continuous uniform channels are excellent candidates for filtration applications. Designing such membranes with the desired physical and chemical properties requires molecular-level understanding of the structure, which can be obtained through molecular modeling. However, building molecular models of bicontinuous cubic structures is challenging due to their narrow regime of stability and the difficulty of self-assembly of large unit cells in molecular simulations. We developed a protocol for building stable bicontinuous cubic unit cells involving both parameterization and assembly of the components. We validate the theoretical structure against experimental results for one such LLC monomer and provide insight into the structure missing in experimental data, as well as demonstrate the qualitative nature of water and solute transport through these membranes.

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Section: Discussionmentioning

confidence: 99%

Obtaining and Characterizing Stable Bicontinuous Cubic Morphologies and Their Nanochannels in Lyotropic Liquid Crystal Membranes

et al. 2022

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“…Q phases of LLCs are particularly attractive as the hydrophobic and hydrophilic channels are continuous in all directions eliminating the daunting task of aligning nanoscale channels. Furthermore, Q structures are found in biological systems 10 and have several technical applications such as drug delivery, 77,78 controlled chemical reactions, 79 and nanofiltration. 8,30 The tunability of the bilayer curvature in the Q phase is also exploited in designing cubosomes 80 intended for drug delivery applications.…”

Section: Discussionmentioning

confidence: 99%

Obtaining and characterizing stable bicontinuous cubic morphologies and their nanochannels in lyotropic liquid crystal membranes

Sahu

Schwindt

Coscia

et al. 2022

Preprint

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Amphiphilic monomers in polar solvents can self-assemble into lyotropic liquid crystal (LLC) bicontinuous cubic structures under the right composition and temperature conditions. After cross-linking, the resulting polymer membranes with 3D continuous uniform channels are excellent candidates for filtration applications. Designing such membranes with desired physical and chemical properties requires molecular level understanding of the structure, which can be obtained through molecular modeling. However, building molecular models of bicontinuous cubic structures is challenging due to their narrow regime of stability and the difficulty of self-assembly of large unit cells in molecular simulations. We developed a protocol for building stable bicontinuous cubic unit cells involving both parameterization and assembly of the components. We validated theoretical structure against experimental results for one such LLC monomer and provide insight into the structure missing in experimental data, as well as demonstrate the qualitative nature of water and solute transport through these membranes.

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“…Phospholipids and cholesterols are the basic need to create liposomes 95 , 96 . Liposomes comprise a lipophilic bilayer and the hydrophilic core part which enables the encapsulation of hydrophobic and hydrophilic drugs into liposomes 97 . Generally, hydrophilic material encapsulates in the core part whereas, lipophilic material is incorporated into the lipid bilayer.…”

Section: Different Nanoparticles Used In Nanotheranosticsmentioning

confidence: 99%

Interventional nanotheranostics in hepatocellular carcinoma

Chavda¹,

Balar²,

Patel³

2023

Nanotheranostics

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Interventional nanotheranostics is a system of drug delivery that does a dual function; along with the therapeutic action, it also does have diagnostic features. This method helps in early detection, targeted delivery, and the least chances of damage to surrounding tissue. It ensures the highest efficiency for the management of the disease. Imaging is the near future for the quickest and most accurate detection of disease. After combing both effective measures, it ensures the most meticulous drug delivery system. Nanoparticles such as Gold NPs, Carbon NPs, Silicon NPS, etc. The article emphasizes on effect of this delivery system in the treatment of Hepatocellular Carcinoma. It is one of the widely spreading diseases and theranostics is trying to make the scenario better. The review suggests the pitfall of the current system and how theranostics can help. It describes the mechanism used to generate its effect and believes that interventional nanotheranostics do have a future with rainbow color. The article also describes the current hindrance to the flourishing of this miraculous technology.

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Lyotropic liquid crystals for parenteral drug delivery

Cited by 40 publications

References 197 publications

Obtaining and Characterizing Stable Bicontinuous Cubic Morphologies and Their Nanochannels in Lyotropic Liquid Crystal Membranes

Obtaining and Characterizing Stable Bicontinuous Cubic Morphologies and Their Nanochannels in Lyotropic Liquid Crystal Membranes

Obtaining and characterizing stable bicontinuous cubic morphologies and their nanochannels in lyotropic liquid crystal membranes

Interventional nanotheranostics in hepatocellular carcinoma

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