Long Lasting Chronic Resistive Training Effects on Circulating S-Klotho and IGF-1

Saghiv, Moran S.; Sherve, Chris; Goldhammer, Ehud; Ben‐Sira, David; Sagiv, Michael

doi:10.26502/acbr.5017007

Cited by 6 publications

(7 citation statements)

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“…[46][47][48] While resistance training showed no to little effect on s-klotho levels, aerobic training, especially chronic aerobic training has been proven to increase the biomarker's levels. 25,[46][47][48] The current study further suggest that s-klotho levels increase from baseline to immediate-post exercise and then decrease. Levels of s-klotho are higher immediatepost and decrease faster in healthy compared to OSA subjects.…”

Section: S-klothomentioning

confidence: 99%

Sixteen weeks of aerobic training influence spirometry, s-klotho, and hemodynamic responses to sub-maximal exercise testing in obese men with severe obstructive sleep apnea

Saghiv¹

2018

SMDIJ

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Section: S-klothomentioning

confidence: 99%

Sixteen weeks of aerobic training influence spirometry, s-klotho, and hemodynamic responses to sub-maximal exercise testing in obese men with severe obstructive sleep apnea

Saghiv¹

2018

SMDIJ

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“…As so far only descriptive studies have been carried out in humans, the effect of strength exercise on SαKl levels remains unclear. Significantly lower levels of SαKl have been reported in weightlifters and sprinters compared to inactive subjects or athletes practicing other disciplines (Saghiv et al, 2015a(Saghiv et al, , 2017a. In contrast, in older adults (>65 years), protein levels have been positively correlated with upper limb strength (Semba et al, 2012) but not with lower limb strength (Semba et al, 2015).…”

Section: Discussionmentioning

confidence: 98%

“…To our knowledge, our study is the first to compare the immediate effects of an acute cardio-respiratory or strength exercise session on plasma SαKl levels, despite several randomized controlled trials of the klotho response to acute cardiorespiratory exercise ( Saghiv et al, 2015a ; Santos-Dias et al, 2017 ; Tan et al, 2018 ). Further, the literature contains only descriptive studies of this response to strength training as the main exercise component (i.e., weightlifters; long-distance runners vs. sprinters; Saghiv et al, 2017a , b ) or studies correlating protein levels with limb strength ( Semba et al, 2012 , 2015 ; Saghiv et al, 2015a ).…”

Section: Discussionmentioning

confidence: 99%

“…However, few studies have examined the effects of strength training on SαKl (Semba et al, 2012(Semba et al, , 2015Saghiv et al, 2017a) and the impacts of acute vs. chronic strength training interventions have not yet been explored. To date, however, there is a sufficient knowledge of molecular mechanisms triggered by strength training to suggest that this form of exercise could have a positive effect on SαKl.…”

Section: Introductionmentioning

confidence: 99%

“…These studies have shown that individuals who regularly practice any activity with a high cardiorespiratory component have greater plasma levels of SαKl ( Saghiv et al, 2015a ; Mostafidi et al, 2016 ). However, few studies have examined the effects of strength training on SαKl ( Semba et al, 2012 , 2015 ; Saghiv et al, 2017a ) and the impacts of acute vs. chronic strength training interventions have not yet been explored. To date, however, there is a sufficient knowledge of molecular mechanisms triggered by strength training to suggest that this form of exercise could have a positive effect on SαKl.…”

Section: Introductionmentioning

confidence: 99%

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Acute Impacts of Different Types of Exercise on Circulating α-Klotho Protein Levels

et al. 2021

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Introduction: Elevated plasma α-klotho (αKl) protects against several ageing phenotypes and has been proposed as a biomarker of a good prognosis for different diseases. The beneficial health effects of elevated plasma levels of soluble αKl (SαKl) have been likened to the positive effects of exercise on ageing and chronic disease progression. It has also been established that molecular responses and adaptations differ according to exercise dose. The aim of this study is to compare the acute SαKl response to different exercise interventions, cardiorespiratory, and strength exercise in healthy, physically active men and to examine the behavior of SαKl 72h after acute strength exercise.Methods: In this quasi-experimental study, plasma SαKl was measured before and after a cardiorespiratory exercise session (CR) in 43 men, and strength exercise session (ST) in 39 men. The behavior of SαKl was also examined 24, 48, and 72h after ST.Results: Significant differences (time×group) were detected in SαKl levels (p=0.001; d=0.86) between CR and ST. After the ST intervention, SαKl behavior varied significantly (p=0.009; d=0.663) in that levels dropped between pre- and post-exercises (p=0.025; d=0.756) and were also significantly higher compared to pre ST values at 24h (p=0.033; d=0.717) and at 48h (p=0.015; d=0.827).Conclusions: SαKl levels increased in response to a single bout of cardiorespiratory exercise; while they decreased immediately after strength exercise, levels were elevated after 24h indicating different klotho protein responses to different forms of exercise.

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Anabolic myokine responses and muscular performance following 8 weeks of autoregulated compared to linear resistance exercise in recreationally active males

Ghobadi,

Attarzadeh Hosseini,

Rashidlamir

et al. 2024

Hormones

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BackgroundTo date, no studies have compared the e cacy of auto-regulated periodized and linear resistance exercises on anabolic myokines and muscular performance among recreationally active individuals. This study aimed to compare the effects of an 8-week auto-regulated periodized resistance exercise(APRE) program with a linear resistance exercise(LRE) program on insulin-like growth factor-1(IGF-1), follistatin(FST), myostatin(MST), body composition, muscular strength, and power in recreationally active males. MethodsThirty males were randomly assigned to either the APRE group(n = 15) or the LRE group(n = 15). Participants completed training three times a week for eight weeks. The outcome measures included serum IGF-1, FST, MST, muscular strength(isometric knee extension, handgrip), power(vertical jump), lean body mass, and fat mass. ResultsIGF-1 circulating levels increased over time following APRE(34%), with no signi cant change following LRE(~-1%). There were no signi cant differences over time or between groups for FST or MST. Muscular strength(knee extension [21.5% vs. ~16%] and handgrip [right: 31% vs. 25%; left: 31.7% vs. 28.8%]) and power(~ 33% vs. ~26%) signi cantly increased to a greater extent following APRE compared to LRE.Interestingly, results revealed that lean body mass increased over time only after APRE(~ 3%), but not LRE. ConclusionThese ndings suggest that APRE may be more effective than LRE in increasing muscular strength, power, and lean body mass, as well as circulating IGF-1 levels, in recreationally active males. The observed differences may be attributed to the increased training volume associated with APRE. However, further research is needed to directly assess muscle protein synthesis. IntdoructionResistance training acutely elevates muscle protein synthesis, which over time leads to muscle accretion and gains in muscular strength and power [1]. Resistance training periodization, or the manipulation of training variables such as intensity, frequency, sets, repetitions, velocity, and recovery time, affects physiological adaptations. Purportedly taking into account an individual's responsiveness to resistance

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Long Lasting Chronic Resistive Training Effects on Circulating S-Klotho and IGF-1

Cited by 6 publications

References 0 publications

Sixteen weeks of aerobic training influence spirometry, s-klotho, and hemodynamic responses to sub-maximal exercise testing in obese men with severe obstructive sleep apnea

Sixteen weeks of aerobic training influence spirometry, s-klotho, and hemodynamic responses to sub-maximal exercise testing in obese men with severe obstructive sleep apnea

Acute Impacts of Different Types of Exercise on Circulating α-Klotho Protein Levels

Anabolic myokine responses and muscular performance following 8 weeks of autoregulated compared to linear resistance exercise in recreationally active males

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