Long-Lasting Antifouling Coating from Multi-Armed Polymer

Mizrahi, Boaz; Khoo, Xiaojuan; Chiang, Homer H.; Sher, Katalina J; Feldman, Rose G; Lee, Jung-Jae; Irusta, Silvia; Kohane, Daniel S.

doi:10.1021/la4014575

Cited by 57 publications

(41 citation statements)

References 57 publications

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“…This yield is comparable with the efficiencies reported by us and by others for modification of PEG 4 with similar molecular weight. For example, our previous reports of substituting PEG 4 with dopamine showed substitution rates of about 77% …”

Section: Resultsmentioning

confidence: 99%

Light-triggered antifouling coatings for porous silicon optical transducers

Bussi

Holtzman

Shagan

et al. 2017

Polym. Adv. Technol.

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Nanostructured porous silicon (PSi) is an attractive platform for the design of biosensors because of its high sensitivity and selectivity towards various biological targets. Its use for biosensing applications, however, is compromised as a result of interfacial interactions with biological molecules that may accumulate on their surfaces and degrade their performance. We describe a new hybrid system comprising an oxidized PSi (PSiO2) nanostructure and antifouling (anti‐adsorption), light‐triggered pre‐polymers that promote crosslinking and surface anchoring to Si walls. The incorporation of the pre‐polymers allowed the production of a thick hydrogel layer on the inorganic nanostructure. Coating completely prevents fouling of proteins on the surface without compromising biosensor performance in terms of sensitivity. The strategy developed here provides a convenient means to combine two distinct features of crosslinking and organic–inorganic hybrid fabrication in a “one‐pot” process. Copyright © 2017 John Wiley & Sons, Ltd.

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Section: Resultsmentioning

confidence: 99%

Light-triggered antifouling coatings for porous silicon optical transducers

Bussi

Holtzman

Shagan

et al. 2017

Polym. Adv. Technol.

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“…3 It was observed that polymers made of poly(ethylene glycol) (PEG) weakly influence the cell viability (≈83%) even after long incubation times of 48 h. 4 In the literature, several approaches are reported to prepare PEG-based coatings, e.g., by the formation of permanent chemical bonds using one or even several reaction steps. 3,5 An intensively studied class of coatings are layers of microgel particles adsorbed at solid surfaces. Microgels are colloidal particles with an inner polymer network structure based on chemical cross-linking.…”

Section: Introductionmentioning

confidence: 99%

“…The combination of appropriate amounts of both tunes the VPTT close to body temperature (≈37°C). 32 In this paper, we report on the investigation of the properties of p-MeO 2 MA-co-OEGMA particles with different amounts of comonomer (5,17, and 26 mol %). We already studied the structural properties of these microgel particles in suspension by DLS and SANS.…”

Section: Introductionmentioning

confidence: 99%

Ethylene Glycol-Based Microgels at Solid Surfaces: Swelling Behavior and Control of Particle Number Density

et al. 2015

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The adsorption of ethylene glycol (EG)-based microgel particles at silicon surfaces was investigated. Monodisperse p-MeO2MA-co-OEGMA microgel particles were synthesized by precipitation polymerization. Particle size and the volume phase transition temperature (VPTT) can be tailored by changing the amount of comonomer. The effect of geometrical confinement on the microgel particles was studied at the solid/liquid interface. Therefore, layer formation, particle number density, and swelling/deswelling at the surface were studied in dependence on the spin-coating preparation parameters and characterized by means of AFM against ambient conditions. The deswelling/swelling behavior was investigated by AFM in the water-swollen state.

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“…PEG is widely used for improving hydrophilicity and protein antifouling property of ultrafiltration membrane. 24,25 Its superior resistance to nonspecific protein adsorption may attribute to the lack of ionic charge, high hydrophilicity, flexibility, and mobility in the aqueous environment. 26,27 The immobilization of PEG onto a material surface to form a hydrophilic layer is an effective way to improve antifouling property.…”

Section: Introductionmentioning

confidence: 99%

Hemocompatible polyethersulfone/polyurethane composite membrane for high-performance antifouling and antithrombotic dialyzer

Yin

Cheng

Qin

et al. 2014

J. Biomed. Mater. Res.

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Researches on blood purification membranes are fuelled by diverse clinical needs, such as hemodialysis, hemodiafiltration, hemofiltration, plasmapheresis, and plasma collection. To approach high-performance dialyzer, the integrated antifouling and antithrombotic properties are highly necessary for the design/modification of advanced artificial membranes. In this study, we propose and demonstrate that the physical blend of triblock polyurethane (PU) and polyethersulfone (PES) may advance the performance of hemodialysis membranes with greatly enhanced blood compatibility. It was found that the triblock PU could be blended with PES at high ratio owing to their excellent miscibility. The surfaces of the PES/PU composite membranes were characterized using attenuated total reflectance-Fourier transform infrared spectroscopy, X-ray photoelectron spectroscopy, water contact angle measurement, and surface ζ-potentials. The results indicated that the membrane surfaces were assembled with hydrophilic segregation layer owing to the migration of amphiphilic PU segments during membrane preparation, which might confer the composite membranes with superior hemocompatibility. The cross-section scanning electron microscopy images of the composite membranes exhibited structure transformation from finger-like structure to sponge-like structure, which indicated that the composite membrane had tunable porosity and permeability. The further ultrafiltration experiments indicated that the composite membranes showed increased permeability and excellent antifouling ability. The blood compatibility observation indicated that PES/PU composite membranes owned decreased protein adsorption, suppressed platelet adhesion, and prolonged plasma recalcification time. These results indicated that the PES/PU composite membranes exhibited enhanced antifouling and antithrombotic properties than the pristine PES membrane. The strategy may forward the fabrication of blood compatible composite membranes for clinical blood dialysis by using the various functional miscible polymers.

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Long-Lasting Antifouling Coating from Multi-Armed Polymer

Cited by 57 publications

References 57 publications

Light-triggered antifouling coatings for porous silicon optical transducers

Light-triggered antifouling coatings for porous silicon optical transducers

Ethylene Glycol-Based Microgels at Solid Surfaces: Swelling Behavior and Control of Particle Number Density

Hemocompatible polyethersulfone/polyurethane composite membrane for high-performance antifouling and antithrombotic dialyzer

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