Light-triggered antifouling coatings for porous silicon optical transducers

Abstract

Nanostructured porous silicon (PSi) is an attractive platform for the design of biosensors because of its high sensitivity and selectivity towards various biological targets. Its use for biosensing applications, however, is compromised as a result of interfacial interactions with biological molecules that may accumulate on their surfaces and degrade their performance. We describe a new hybrid system comprising an oxidized PSi (PSiO2) nanostructure and antifouling (anti‐adsorption), light‐triggered pre‐polymers that promote crosslinking and surface anchoring to Si walls. The incorporation of the pre‐polymers allowed the production of a thick hydrogel layer on the inorganic nanostructure. Coating completely prevents fouling of proteins on the surface without compromising biosensor performance in terms of sensitivity. The strategy developed here provides a convenient means to combine two distinct features of crosslinking and organic–inorganic hybrid fabrication in a “one‐pot” process. Copyright © 2017 John Wiley & Sons, Ltd.

Light‐triggered stabilization of microgel aggregates

“…In another study, the size and morphology of photocross-linkable nanoparticles containing cinnamate groups were controlled for a desired time during hydrolysis by means of additional UV irradiation. 39 In a previous study, 40 we demonstrated the ability of a PEG 4 -CAA conjugate of higher molecular weight to serve as an antifouling hydrogel owing to the fact that both PEG 4 Compared with other photoresponsive molecules such as azide 41 and anthracene, 42 this system provides a simple step for synthesizing biosafe molecules without compromising stabilization efficiency, which makes fabrication more amenable to large-scale production.…”

“…In another study, the size and morphology of photocross‐linkable nanoparticles containing cinnamate groups were controlled for a desired time during hydrolysis by means of additional UV irradiation . In a previous study, we demonstrated the ability of a PEG 4 ‐CAA conjugate of higher molecular weight to serve as an antifouling hydrogel owing to the fact that both PEG 4 and CAA have inherent antifouling properties. This light‐triggered protecting layer anchored efficiently to the silicon walls of biosensors, thus preventing fouling of proteins on them without compromising biosensor sensitivity.…”

Near-Infrared Light Induced Phase Transition of Biodegradable Composites for On-Demand Healing and Drug Release

“…Stimuli responsive materials play an important role in many biomedical applications, including drug delivery, self-healing coatings, , medical adhesives, and antifouling surfaces. , These materials are capable of responding to external stimuli, such as pH, redox, enzymes, light, temperature, magnetic, and electrical signal by changing their physicochemical properties. Among these, light is of particular interest, since its parameters (distance, intensity, wavelength, etc.)…”