Long intergenic non-protein-coding RNA 01446 facilitates the proliferation and metastasis of gastric cancer cells through interacting with the histone lysine-specific demethylase LSD1

Lian, Yifan; Yan, Changsheng; Lian, Yikai; Yang, Renzhi; Chen, Qiongyun; Ma, Dan; Lian, Weibin; Liu, Jingjing; Luo, Chen; Ren, Jianlin; Xu, Hui

doi:10.1038/s41419-020-2729-0

Cited by 11 publications

(10 citation statements)

References 40 publications

(44 reference statements)

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“…Xu et al have validated that PVT1 with upregulated expression in GC through activation of FOXM1 transcription acts as a oncogene. (Lian et al, 2020). Additionally, a study confirmed AK023391 as a novel oncogenic lncRNA in GC that exhibited functions by mediating the PI3K-Akt signaling pathway (Huang et al, 2017).…”

Section: Discussionmentioning

confidence: 83%

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Survival-Related lncRNA Landscape Analysis Identifies LINC01614 as an Oncogenic lncRNA in Gastric Cancer

Zhou

Chen

et al. 2021

Front. Genet.

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Background: Long non-coding RNAs (lncRNAs) reportedly play important roles in biomarker and tumorigenesis of gastric cancer (GC). This study aimed to determine the potential application of prognostic lncRNA signature and identified the role of LINC01614 in carcinogenesis in GC.Material and Methods: Data accessed from the Cancer Genome Atlas database was used to construct a lncRNA signature. Joint effect analysis of the signature and clinical parameters was performed to verify the clinical value of the signature. Co-expression analysis was conducted for prognostic lncRNAs and protein-coding genes. Moreover, the relative expression of LINC01614 was validated in GC tissues and cell lines. In vitro and in vivo experiments were conducted to analyze the biological functions of the newly identified gene in GC cells.Results: A seven-lncRNA (LINC01614, LINC01537, LINC01210, OVAAL, LINC01446, CYMP-AS1, and SCAT8) signature was identified as a promising prognostic signature in GC. Results indicated that the seven-lncRNA was involved in tumorigenesis and progression pathways. LINC01614 expression was identified and found to be upregulated in GC tissues and cells. The study findings revealed that LINC01614 promoted cell proliferation, migration, invasion, and epithelial-mesenchymal transition. Knockdown of LINC01614 arrested cell cycle distribution at the G2/M phase. Further, LINC01614 also promoted tumor growth in vivo.Conclusion: We developed an independent seven-lncRNA biomarker for prognostic prediction and identified LINC01614 as an oncogenic lncRNA in GC.

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Section: Discussionmentioning

confidence: 83%

“…LINC01446 functions as an oncogene and promotes GC and glioblastoma progression and indicates a poor prognosis, an effect similar to that predicted here. (Lian et al, 2020;Zhang et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

Survival-Related lncRNA Landscape Analysis Identifies LINC01614 as an Oncogenic lncRNA in Gastric Cancer

Zhou

Chen

et al. 2021

Front. Genet.

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“…The proteins of the Jumonji C (JmjC) containing family are mainly composed of 2-oxoglutarate (2OG)- and Fe 2+ -dependent histone demethylase, of which JMJD6 is an important member [ 101 ]. In recent years, JMJD6 has been thought to be related to the occurrence and development of a variety of tumors, including breast cancer, melanoma, oral cancer, glioblastoma, hepatocellular carcinoma, colon cancer, ovarian cancer and neuroglioma [ 101 – 110 ]. For instance, in ovarian cancer, Zheng et al found that JMJD6 was highly expressed in tumor cells by tissue microarray immunohistochemical staining, and the high expression was associated with poor prognosis of patients [ 108 ].…”

Section: Epigenetic Regulation Of Hifs Activitymentioning

confidence: 99%

Epigenetic crosstalk between hypoxia and tumor driven by HIF regulation

Mao

Wang

et al. 2020

J Exp Clin Cancer Res

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Hypoxia is the major influence factor in physiological and pathological courses which are mainly mediated by hypoxia-inducible factors (HIFs) in response to low oxygen tensions within solid tumors. Under normoxia, HIF signaling pathway is inhibited due to HIF-α subunits degradation. However, in hypoxic conditions, HIF-α is activated and stabilized, and HIF target genes are successively activated, resulting in a series of tumour-specific activities. The activation of HIFs, including HIF-1α, HIF-2α and HIF-3α, subsequently induce downstream target genes which leads to series of responses, the resulting abnormal processes or metabolites in turn affect HIFs stability. Given its functions in tumors progression, HIFs have been regarded as therapeutic targets for improved treatment efficacy. Epigenetics refers to alterations in gene expression that are stable between cell divisions, and sometimes between generations, but do not involve changes in the underlying DNA sequence of the organism. And with the development of research, epigenetic regulation has been found to play an important role in the development of tumors, which providing accumulating basic or clinical evidences for tumor treatments. Here, given how little has been reported about the overall association between hypoxic tumors and epigenetics, we made a more systematic review from epigenetic perspective in hope of helping others better understand hypoxia or HIF pathway, and providing more established and potential therapeutic strategies in tumors to facilitate epigenetic studies of tumors.

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“… 7 , 8 Aberrant expression of lncRNAs may lead to dysregulation of proliferation, survival, and metastasis of tumor cells. 9 For example, lncRNA JPX is upregulated in lung cancer and promotes tumor development through targeting miR-145/CCND2 axis. 10 LncRNA OIP5-AS1 overexpression contributes to proliferation, migration, and invasion in pancreatic ductal adenocarcinoma.…”

Section: Introductionmentioning

confidence: 99%

LncRNA DDX11-AS1 Exerts Oncogenic Roles in Glioma Through Regulating miR-499b-5p/RWDD4 Axis

Zheng¹,

Xie²,

Xu³

et al. 2021

OTT

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Background: Long noncoding RNAs (lncRNA) exert essential functions during tumorigenesis. However, how lncRNAs participate in glioma development remains poorly researched. This study aimed to determine how DDX11-AS1 affects glioma progression. Methods: Gene expression was analyzed by qRT-PCR. Survival rate curve was plotted in 56 glioma patients. Loss-of-function assays were performed to analyze proliferation, migration, and invasion through CCK8, colony formation, and transwell assays. Luciferase assay and RNA pulldown assays were conducted to illustrate the underlying molecular mechanism. Results: DDX11-AS1 expression was upregulated in glioma tissues and cells. DDX11-AS1 overexpression was linked with poor prognostic value. DDX11-AS1 knockdown suppressed proliferation, migration, and invasion while inducing apoptosis. DDX11-AS1 interacted with miR-499b-5p to eliminate it, leading to upregulation of RWDD4 expression. RWDD4 was upregulated in glioma while miR-499b-5p was downregulated. Conclusion: DDX11-AS1 upregulation promotes glioma progression through acting as a competing endogenous RNA for miR-499b-5p to upregulate RWDD4.

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Long intergenic non-protein-coding RNA 01446 facilitates the proliferation and metastasis of gastric cancer cells through interacting with the histone lysine-specific demethylase LSD1

Cited by 11 publications

References 40 publications

Survival-Related lncRNA Landscape Analysis Identifies LINC01614 as an Oncogenic lncRNA in Gastric Cancer

Survival-Related lncRNA Landscape Analysis Identifies LINC01614 as an Oncogenic lncRNA in Gastric Cancer

Epigenetic crosstalk between hypoxia and tumor driven by HIF regulation

LncRNA DDX11-AS1 Exerts Oncogenic Roles in Glioma Through Regulating miR-499b-5p/RWDD4 Axis

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