Long-continued Inhibition of Gastric Secretion by Poldine Methosulphate in Patients with Peptic Ulcer

Douthwaite, A. H.; Hills, T. H.; Hunt, J. N.

doi:10.1136/bmj.1.5239.1575

Cited by 11 publications

(2 citation statements)

References 3 publications

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“…However, more recent observations by this group (Posey, Elliott, Shewmake, and Posey, 1968) indicate that maximal acid output and parietal cell mass remain constant in dogs during prolonged treatment with glycopyrronium. In 16 patients with peptic ulcer (14 duodenal, two gastric) treated for a mean period of three years with poldine methylsulphate, Douthwaite, Hills, and Hunt (1961) found a 50% reduction in acid secretion measured by the distension test meal. This reduction persisted, with some individual fluctuations, throughout the period of drug administration.…”

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confidence: 97%

Gastric acid secretion in patients with duodenal ulcer treated for one year with anticholinergic drugs

Kaye¹,

Beck²,

Rhodes³

et al. 1969

Gut

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SUMMARY Ninety patients with duodenal ulcer, divided randomly into three groups, were treated continuously for one year with either glycopyrronium, 1-hyoscyamine (as a sustained-release preparation) or inert tablets. Dosage with active tablets was so adjusted that the patient experienced definite but tolerable side-effects. Basal and maximal gastric acid secretion were measured immediately before and one week after cessation of treatment. There was no significant change in the means of these measurements in patients who received placebo or 1-hyoscyamine. In Wales, 1966) it was stated that reduced levels of acid secretion persisted for up to 30 months after the drug had been stopped. This maintained reduction was thought to reflect the course of the underlying disorder rather than a direct effect of the anticholinergic drug.In this report, we describe our findings in a group of 90 patients with duodenal ulcer who were treated continuously for one year with anticholinergic drugs. PATIENTS AND METHODSAll patients were male, had a duodenal ulcer recently demonstrated by radiograph, and had had symptoms within six months of the first examination. They were taking part in a trial of long-term anticholinergic therapy, full details of which will be published shortly, and were allocated randomly to one of three groups.

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confidence: 97%

Gastric acid secretion in patients with duodenal ulcer treated for one year with anticholinergic drugs

Kaye¹,

Beck²,

Rhodes³

et al. 1969

Gut

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show abstract

“…The OED thus varies from one patient to another, and according to the preparation employed. With optimal doses of anticholinergic drugs there is an inhibition of basal Submitted for publication July 2, 1964. secretion, as well as of secretion stimulated after food, histamine and insulin hypoglycaemia (1,2,5,6,10,11,12,14).…”

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confidence: 99%

The Effect of Poldine, Glycopyrrolate and 1‐Hyoscyamine on Gastric Secretion of Acid in Man

Dotevall

Schröder

Walan

1965

Journal of Internal Medicine

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Schleimhauthyperplasie des Magens

Stadelmann

1974

Magen

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Long-continued Inhibition of Gastric Secretion by Poldine Methosulphate in Patients with Peptic Ulcer

Cited by 11 publications

References 3 publications

Gastric acid secretion in patients with duodenal ulcer treated for one year with anticholinergic drugs

Gastric acid secretion in patients with duodenal ulcer treated for one year with anticholinergic drugs

The Effect of Poldine, Glycopyrrolate and 1‐Hyoscyamine on Gastric Secretion of Acid in Man

Schleimhauthyperplasie des Magens

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