“…The effect of anticholinergic agents on the stomach has been assessed by measuring basal acid secretion (Sun and Shay, 1955;Grossman, 1958;Juniper et al, 1964), secretion in response to a standard meal (Mitchell et al, 1962), to insulin-induced hypoglycaemia (Piper and Stiel, 1962), or to histamine (Seidelin, 1961;Dotevall et al, 1965); but there is no general agreement as to the best method. We have used an infusion of histamine in submaximal dosage, since this is more sensitive than a maximal dose in demonstrating anticholinergic effect (Dotevall, Walan, and Weinfeld, 1967).…”