The Effect of Poldine, Glycopyrrolate and 1‐Hyoscyamine on Gastric Secretion of Acid in Man

The effect of an H2-receptor antagonist on food-stimjlated acid secretion, serum gastrin, and gastric emptying in patients with duodenal ulcers. Comparison with an anticholinergic drug.

“…It is clear, however, that anticholinergic drugs in maximum tolerated doses can reduce food-stimulated secretion to only a modest extent. This is in contrast to basal (unstimulated) secretion, which is reduced from 50 to 80% by a maximum tolerated dose of various anticholinergic drugs (15,16).…”

Clinical evaluation of three long-acting anticholinergic compounds.

“…Since there is considerable individual variation in response, it is uncertain whether the doses of the different drugs used were 8 equivalent, so that such comparisons are of questionable validity. In other studies, drugs were given in maximal dosage without side effects (Mitchell et al, 1962) or in doses which caused tolerable side effects (Sun and Shay, 1955;Dotevall, Schroder, and Walan, 1965), but the functions of organs other than the stomach were assessed on a purely subjective basis.…”

“…The effect of anticholinergic agents on the stomach has been assessed by measuring basal acid secretion (Sun and Shay, 1955;Grossman, 1958;Juniper et al, 1964), secretion in response to a standard meal (Mitchell et al, 1962), to insulin-induced hypoglycaemia (Piper and Stiel, 1962), or to histamine (Seidelin, 1961;Dotevall et al, 1965); but there is no general agreement as to the best method. We have used an infusion of histamine in submaximal dosage, since this is more sensitive than a maximal dose in demonstrating anticholinergic effect (Dotevall, Walan, and Weinfeld, 1967).…”

Determination of Peptic Activity and Acid in the Gastric Juice of Patients with Peptic Disease Before and After Administration of Glycopyrrolate

“…While the ability o€ glycopyrrolate to inhibit the acid secretion in patients with peptic disease is well-known (1,2,5,7,19,22,30,31), its influence upon the secretion of pepsin appears to have been studied by one author only (18). After administration of 4 mg glycopyrrolate by mouth to 5 patients with dyspepsia and hypersecretion, Moeller (18) found a reduction in the pepsin output of only 67.7 % as compared with our 88 %.…”