Long-circulating iron oxides for MR imaging

Weissleder, Ralph; Bogdanov, Alexei A.; Neuwelt, Edward A.; Papisov, Mikhail

doi:10.1016/0169-409x(95)00033-4

Cited by 383 publications

(295 citation statements)

References 34 publications

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“…131,159 Following internalization, SPIO generally accumulate in lysosomes where the iron oxide core is broken down to iron ions through low pH exposure and these ions are incorporated into the hemoglobin pool. 154 Intracellular dextranase further assist with the degradation process by cleaving the dextran moiety. The use of dextran-iron complexes in vivo, stretches back over half a century, initially as a means to treat anemia.…”

Section: Biocompatibilitymentioning

confidence: 99%

Superparamagnetic Iron Oxide Nanoparticle Probes for Molecular Imaging

et al. 2006

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Abstract-The field of molecular imaging has recently seen rapid advances in the development of novel contrast agents and the implementation of insightful approaches to monitor biological processes non-invasively. In particular, superparamagnetic iron oxide nanoparticles (SPIO) have demonstrated their utility as an important tool for enhancing magnetic resonance contrast, allowing researchers to monitor not only anatomical changes, but physiological and molecular changes as well. Applications have ranged from detecting inflammatory diseases via the accumulation of non-targeted SPIO in infiltrating macrophages to the specific identification of cell surface markers expressed on tumors. In this article, we attempt to illustrate the broad utility of SPIO in molecular imaging, including some of the recent developments, such as the transformation of SPIO into an activatable probe termed the magnetic relaxation switch.

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Section: Biocompatibilitymentioning

confidence: 99%

Superparamagnetic Iron Oxide Nanoparticle Probes for Molecular Imaging

et al. 2006

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“…The structure of the synthesized AmPEG was determined by 1 HNMR spectroscopy in CDCl 3 . Vinylic protons of AmPEG were splitted into three different peaks which were located at 6.15 (-COCHC = C-), 5.85 ppm (-COCHC = CH-, cis-proton) and 6.45 ppm (-COCHC = CH-, trans-proton) (Fig.…”

Section: Synthesis Of Magnetite Nanoparticles (Mnps)mentioning

confidence: 99%

“…Magnetic iron oxide nanoparticles with tailored surface chemistry have been widely used experimentally for numerous in vivo applications such as magnetic resonance imaging, contrast enhancement, tissue repair, immunoassay, detoxification of biological fluids, hyperthermia, drug delivery and in cell separation [1][2][3][4][5]. Coating or modifying these nanoparticles with hydrophilic molecules, especially biomolecules, is a crucial step for the preparation of waterdispersible magnetite nanoparticles (MNPs) for use in biological applications [6].…”

Section: Introductionmentioning

confidence: 99%

A new procedure for preparation of polyethylene glycol-grafted magnetic iron oxide nanoparticles

Khoee

Kavand

2014

J Nanostruct Chem

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Magnetic iron oxide nanoparticles (MNPs) have been widely explored for use in biomedical applications. In the present study, iron oxide nanoparticles were connected to methoxy poly(ethylene glycol) (mPEG) via a new method. The mPEG was acrylated at first and Michael reaction was carried out between acrylated mPEG and 3-aminopropyl triethoxysilane as a coupling agent. The chemical structures of modified mPEG were characterized by Fourier transform-infrared spectroscopy (FT-IR) and nuclear magnetic resonance. In the next step, iron oxide nanoparticle was coupled with the above-mentioned adduct. Preparation of magnetic nanoparticles with average particle size of 20-30 nm was proved by scanning electron microscopy. The structure of mPEG grafted on the surface of MNPs was confirmed by FT-IR spectroscopy and thermal gravimetric analysis. The synthesized nanoparticles have the potential to be used in different biomedical applications.

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“…In particular, MNPs present exciting new opportunities including dual functionality of site-specific delivery of anticancer drugs coupled with an enhanced quality of magnetic resonance imaging (MRI) [8]. Thus, MNPs have the potential to revolutionize current clinical diagnostic and therapeutic strategies for CaP patients [9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Chemotherapy of Prostate Cancer by Targeted Nanoparticles Trackable by Magnetic Resonance Imaging

Abdalla

Turner

Yates

2012

ISRN Nanotechnology

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Prostate cancer (CaP) is the commonest diagnosed malignancy and the second main cause of cancer mortality in males in the United States. Thus, there is an urgent need to develop novel drug delivery systems to improve the chemotherapy option for CaP patients. The goal of this paper is to describe novel moleculary guided nanoscale drug delivery system with dual functionality for treatment and MR imaging of CaP. We describe the synthesis of iron oxide nanoparticles (IONPs) which are then coated with carboxyl-ended amphiphilic polymer. We present the protocol for tethering of the CaP targeting protein, human amino terminal fragment (hATF) to the terminal carboxyls of the IONPs. We describe the drug loading and release and the methods for measuring of the internalization of the hATF-guided IONPs into CaP cells. We also describe the methods for usages of IONPs are MR imaging contrast agent and successful targeted drug carriers.

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Long-circulating iron oxides for MR imaging

Cited by 383 publications

References 34 publications

Superparamagnetic Iron Oxide Nanoparticle Probes for Molecular Imaging

Superparamagnetic Iron Oxide Nanoparticle Probes for Molecular Imaging

A new procedure for preparation of polyethylene glycol-grafted magnetic iron oxide nanoparticles

Chemotherapy of Prostate Cancer by Targeted Nanoparticles Trackable by Magnetic Resonance Imaging

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