A new procedure for preparation of polyethylene glycol-grafted magnetic iron oxide nanoparticles

Khoee, Sepideh; Kavand, Alireza

doi:10.1007/s40097-014-0111-4

Cited by 35 publications

(25 citation statements)

References 24 publications

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“…Thus among the three kinds of molar content of folate groups, FA‐F127‐PCL nanoparticles with 10% molar content of folate group possess the best anticancer activity. These results were similar to the published data . These could be because that too much molar content of folate groups on the surface of nanoparticles would restrict the targeting ability of nanoparticles over the cancer cells due to the stereo‐hindrance effect.…”

Section: Resultssupporting

confidence: 91%

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Effect of the Folate Ligand Density on the Targeting Property of Folated‐Conjugated Polymeric Nanoparticles

Gong

Xiong

et al. 2018

Macromolecular Bioscience

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Targeted drug delivery systems have attracted increasing attention due to their ability for delivering anticancer drugs selectively to tumor cells. Folic acid (FA)‐conjugated targeted block copolymers, FA‐Pluronic‐polycaprolactone (FA‐Pluronic‐PCL) are synthesized in this study. The anticancer drug paclitaxel (PTX) is loaded in FA‐Pluronic‐PCL nanoparticles by nanoprecipitation method. The in vitro release of PTX from FA‐Pluronic‐PCL nanoparticles shows slow and sustained release behaviors. The effect of FA ligand density of FA‐Pluronic‐PCL nanoparticles on their targeting properties is examined by both cytotoxicity and fluorescence methods. It is shown that FA‐Pluronic‐PCL nanoparticles indicated better targeting ability than non‐targeted PCL‐Pluronic‐PCL nanoparticles. Furthermore, FA‐F127‐PCL nanoparticle with 10% FA molar content has more effective antitumor activity and higher cellular uptake than those with 50% and 91% FA molar content. These results prove that FA‐F127‐PCL nanoparticle with 10% FA molar content can be a better candidate as the drug carrier in targeted drug delivery systems.

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Section: Resultssupporting

confidence: 91%

“…Too low FA ligand density may decrease the targeting effect of nanoparticles. However, too high FA ligand density may make FA‐conjugated nanoparticles affect normal cells . Thus, the effect of FA ligand density on the targeting ability of FA‐Pluronic‐PCL copolymers has also been explored.…”

Section: Introductionmentioning

confidence: 99%

Effect of the Folate Ligand Density on the Targeting Property of Folated‐Conjugated Polymeric Nanoparticles

Gong

Xiong

et al. 2018

Macromolecular Bioscience

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“…Interestingly, PEG can influence changes in magnetic response of superparamagnetic materials. It has been reported, especially for NPs that have been synthetized in the presence of PEG, that there was an increase in magnetic moment of such materials . However, the use of PEG in this study was as a coating once the NPs were incorporated into the BC to confer biocompatibility of the IONP.…”

Section: Discussionmentioning

confidence: 95%

Synthesis and in vitro safety assessment of magnetic bacterial cellulose with porcine aortic smooth muscle cells

Pastrana

Cooper

Alucozai

et al. 2016

J Biomedical Materials Res

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Bacterial cellulose (BC) has been used as a scaffold for tissue regeneration (TR). Improving functional TR requires highly selective strategies for specific cell attraction. Embedding iron oxide nanoparticles into a BC matrix can drive magnetically labeled cells to specific tissues where they may begin to heal injured tissue. This article focuses on characterization and in vitro toxicity assessment of magnetic BC (MBC). We proposed to detect the production of radical oxygen species (ROS), esterase activity, and apoptosis to study cytotoxic interactions of MBC within its bioenvironment. Morphological characterization was performed using scanning electron microscopy where evidence shows that the diameter of MBC fibers compared to BC fibers was 33% smaller, and the pore areas were 25% bigger. Cytotoxicity assays in porcine aortic smooth muscle cells exposed for 24 hours to BC, MBC, and poly(ethylene glycol)-coated MBC (MBC-PEG) reveals 96% viability and 9% ROS production for MBC-PEG. In contrast, 25% of cells exposed to MBC were apoptotic, suggesting that even when the cells were metabolically active, MBC can induce damage. These outcomes support the need for more integral assessment in the hopes of assessing the potential biosafety and uses of nanocomposites for TR. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 2801-2809, 2016.

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“…The CMCs of the copolymers were determined using the fluorescent probe technique with pyrene as a hydrophobic fluorescent probe as described previously …”

Section: Methodsmentioning

confidence: 99%

Preparation of new dendrimer-like star-shaped amphiphilic poly(ethylene glycol)-poly(ϵ -caprolactone) copolymers for biocompatible and high-efficiency curcumin delivery

2015

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Novel amphiphilic star‐shaped terpolymers comprised of hydrophobic poly(ϵ‐caprolactone), pH‐sensitive polyaminoester block and hydrophilic poly(ethylene glycol) (Mn = 1100, 2000 g mol−1) were synthesized using symmetric pentaerythritol as the core initiator for ring‐opening polymerization (ROP) reaction of ϵ‐caprolactone functionalized with amino ester dendrimer structure at all chain ends. Subsequently, a second ROP reaction was performed by means of four‐arm star‐shaped poly(ϵ‐caprolactone) macromer with eight ‐OH end groups as the macro‐initiator followed by the attachment of a poly(ethylene glycol) block at the end of each chain via a macromolecular coupling reaction. The molecular structures were verified using Fourier transform infrared and 1H NMR spectroscopies and gel permeation chromatography. The terpolymers easily formed core–shell structural nanoparticles as micelles in aqueous solution which enhanced drug solubility. The hydrodynamic diameter of these agglomerates was found to be 91–104 nm, as measured using dynamic light scattering. The hydrophobic anticancer drug curcumin was loaded effectively into the polymeric micelles. The drug‐loaded nanoparticles were characterized for drug loading content, encapsulation efficiency, drug–polymer interaction and in vitro drug release profiles. Drug release studies showed an initial burst followed by a sustained release of the entrapped drug over a period of 7days at pH = 7.4 and 5.5. The release behaviours from the obtained drug‐loaded nanoparticles indicated that the rate of drug release could be effectively controlled by pH value. Altogether, these results demonstrate that the designed nanoparticles have great potential as hydrophobic drug delivery carriers for cancer therapy. © 2015 Society of Chemical Industry

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A new procedure for preparation of polyethylene glycol-grafted magnetic iron oxide nanoparticles

Cited by 35 publications

References 24 publications

Effect of the Folate Ligand Density on the Targeting Property of Folated‐Conjugated Polymeric Nanoparticles

Effect of the Folate Ligand Density on the Targeting Property of Folated‐Conjugated Polymeric Nanoparticles

Synthesis and in vitro safety assessment of magnetic bacterial cellulose with porcine aortic smooth muscle cells

Preparation of new dendrimer-like star-shaped amphiphilic poly(ethylene glycol)-poly(ϵ -caprolactone) copolymers for biocompatible and high-efficiency curcumin delivery

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