A large-scale isolation of the constituents of the cashew shell oil (Anacardium occidentale) was performed by medium-pressure liquid chromatography. A series of 12 components was isolated, including derivatives of anacardic acid, cardol, 2-methylcardol, and cardanol that differ in their side chain. These were tested against Biomphalaria glabratus, one of the snail vectors of schistosomiasis, and their structure-activity relationship is discussed. The principal components in the shell oil, nuts, and fruit juice were also quantitatively determined by high-performance liquid chromatography.