2009
DOI: 10.1093/eurheartj/ehp398
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Long- but not short-term multifactorial intervention with focus on exercise training improves coronary endothelial dysfunction in diabetes mellitus type 2 and coronary artery disease

Abstract: This is the first study to demonstrate improvement in coronary endothelial function by a multifactorial intervention which focused on exercise training in patients with T2DM. This coincided with improved markers of hyperglycaemia, insulin sensitivity, and inflammation both in serum and skeletal muscle biopsies.

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Cited by 99 publications
(76 citation statements)
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“…Glucose metabolism and coronary endothelial function improved after 6 months of intervention, whereas plaque burden remained unchanged 97. However, the sample size (11 versus 12 patients) was small.…”
Section: Mechanism 3: Regression Of Coronary Stenosismentioning
confidence: 89%
“…Glucose metabolism and coronary endothelial function improved after 6 months of intervention, whereas plaque burden remained unchanged 97. However, the sample size (11 versus 12 patients) was small.…”
Section: Mechanism 3: Regression Of Coronary Stenosismentioning
confidence: 89%
“…Exercisesdone in outdoor sports parks, as well as its psychological benefits also contributes to the individualin terms of prevention of various diseases such as osteoporosis and type-2 diabetes (30). Obtaining the health benefits require regular and programmed physical activities (34).…”
Section: Introductionmentioning
confidence: 99%
“…13 Of all possible interventions, physical activity is the treatment that both counteracts the major modifiable risk factor of physical inactivity and either directly influences all the other modifiable risk factors or helps in the adaptation of a lifestyle that supports healthy behavior and thereby beneficially affects these risk factors (Figure 1). 12 As a consequence, exercise training has become the mainstay of both inpatient and outpatient cardiac rehabilitation because it ameliorates symptoms, reduces ischemia, improves endothelial function, [14][15][16] induces regression or attenuation of progression of the disease, [17][18][19][20] and reduces morbidity and mortality. [21][22][23][24][25] This is manifested in current guidelines and position papers from all the major cardiac societies.…”
Section: Response By Mendes On P 2537mentioning
confidence: 99%