Long-Acting β 2 -Agonists and Risk of Hypertensive Disorders of Pregnancy: A Cohort Study

Blais, Lucie; Kettani, Fatima-Zohra; Forget, Amélie; Beauchesne, Marie-France; Lemière, Catherine; Rey, Évelyne

doi:10.1016/j.jaip.2017.07.004

Cited by 8 publications

(2 citation statements)

References 42 publications

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“…Also, exposure to the combination of LABA and ICS is associated with renal dysplasia [39]. However, in the cohort study of 567 cases of hypertensive disorders of pregnancy and 256 cases of preeclampsia/eclampsia, LABA use is not associated with increased risks of HDP or preeclampsia/eclampsia, suggesting the safety of LABAs for the cure of asthma in pregnancy [40]. Besides, maternal asthma is closely associated with increased risk of offspring autism spectrum disorder (ASD), but this adverse effect is not associated with prenatal exposure to asthma medications including LABA [41].…”

Section: Beta2-agonistmentioning

confidence: 99%

Asthma in Pregnancy: Pathophysiology, Diagnosis, Whole-Course Management, and Medication Safety

Wang

Huang

2020

Canadian Respiratory Journal

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Asthma in pregnancy is a health issue of great concern. Physiological changes and drug compliance during pregnancy can affect asthma control in varying degrees, and the control level of asthma and the side effects of asthma medications are closely related to the adverse perinatal outcomes of mother and fetus. is article provides an update on the available literature regarding the alleviating or aggravating mechanism of asthma in pregnancy, diagnosis, disease assessment, and systematic management, to provide a new guidance for physician, obstetric joint doctor, and health care practitioner.

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Section: Beta2-agonistmentioning

confidence: 99%

Asthma in Pregnancy: Pathophysiology, Diagnosis, Whole-Course Management, and Medication Safety

Wang

Huang

2020

Canadian Respiratory Journal

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“…Research, Society and Development, v. 9, n. 7, e714974626, 2020 (CC BY 4.0) | ISSN 2525-3409 | DOI: http://dx.doi.org/10.33448/rsd-v9i7.4626 10 A seleção do anti-hipertensivo a ser utilizado depende da segurança e eficácia que o fármaco apresenta para a mãe e o feto, visando à administração de doses mínimas e à escolha de medicamentos que possuem apenas um fármaco em sua formulação, com o intuito de conter prováveis efeitos colaterais. Portanto, são adotados fármacos que possuem mais informações registradas na literatura (Olson-Chen & Seligman, 2016 (Blais, et al, 2018;Butalia, et al, 2018). E quando comparado ao alfa agonista, metildopa, apresenta resultado terapêutico mais eficaz (Magee, et al, 2014).…”

Section: Hipertensão Gestacionalunclassified

A importância do cuidado farmacêutico em mulheres no período gestacional

Guedes¹,

Brito²,

Silva³

2020

RSD

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Pharmaceutical care is a relevant service to promote the rational drug use and pharmacotherapeutic success, due to the pharmacist's knowledge and accessibility. On this regard, there is a great relevance on providing this service to pregnant women, due to the possible maternal-fetal risks associated with some drugs. As well as pre-existing diseases and conditions for instance, arterial hypertension and gestational diabetes mellitus which require the use of pharmacological therapies and are of great relevance in Brazilian public health. Due to the high incidence and the complications they may cause, it is an opportune period for the pharmaceutical care to assist treatment adherence and consequently achieve therapeutic success. In this context, the aim of this study is to understand the importance of clinical pharmacists in the pharmacological care during pregnancy. A research was carried out in the databases Scielo, Google Scholar, PubMed and ScienceDirect databases, using the descriptors: risk categories; hypertension; diabetes mellitus; self-medication; pregnancy; nausea; vomiting; eclampsia and pharmaceutical assistance, all selected from DeCS in the languages: Portuguese and English. The importance of pharmaceutical care in pregnancy was evidenced through this study regarding not only the safety and adequate guidance to the use of drug therapies to reduce self-medication, but also the therapeutic adherence process through continuous and regular monitoring. Hence, contributing to the improvement of both maternal and fetal life quality by the pharmaceutical care that highlights whenever necessary the importance of correct treatment compliance and advises the need of therapeutic interventions. Therefore, this study has a unique relevance once it explained the pharmaceutical care importance for pregnant women. Furthermore, it collaborates for the development of plans and actions that aim to expose and conscientize the importance of the clinical pharmacist during this period.

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Perinatal pharmacoepidemiology: How often are key methodological elements reported in publications?

Margulis¹,

Kawai

Anthony

et al. 2021

Pharmacoepidemiology and Drug

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Purpose: Publications provide important information for clinicians, researchers, and patients. Key methodological elements must be reported for maximum transparency.We identified key methodological elements necessary for fully understanding perinatal pharmacoepidemiology research and quantified the proportion of studies that reported these elements in a sample of publications.Methods: Key methodological elements were identified from guidelines from regulatory agencies, literature, and subject-matter knowledge: source of information to determine pregnancy start; mother-or father-infant linkages (process, success rate); unit of analysis; and whether non-live births and fetuses with various anomalies were included in the study population. We conducted a literature review for recent observational studies on medical product utilization or safety during pregnancy and estimated the prevalence of reporting these elements.Results: Data were extracted from a random sample of 100 publications; 8% were published in epidemiology/pharmacoepidemiology journals; 85% were medical product-safety studies. Of publications for which each element was applicable, 43% reported the source for determining pregnancy start; 57%, whether the study population included multifetal pregnancies; 39%, whether it included more than one pregnancy per woman; 27%, whether it included fetuses with chromosomal abnormalities; 60%, fetuses with major congenital malformations; and 93%, non-live births. Of the 20 studies with mother-infant linkage, 35% described the process; 21% reported the linkage success rate. Among studies with more than one pregnancy/ offspring per woman, 22% reported methods addressing sibling correlation. Conclusions:In this sample of pregnancy-related pharmacoepidemiology publications, completeness of reporting could have been improved. A pregnancy-specific checklist would increase transparency in the dissemination of study results.

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Long-Acting β 2 -Agonists and Risk of Hypertensive Disorders of Pregnancy: A Cohort Study

Cited by 8 publications

References 42 publications

Asthma in Pregnancy: Pathophysiology, Diagnosis, Whole-Course Management, and Medication Safety

Asthma in Pregnancy: Pathophysiology, Diagnosis, Whole-Course Management, and Medication Safety

A importância do cuidado farmacêutico em mulheres no período gestacional

Perinatal pharmacoepidemiology: How often are key methodological elements reported in publications?

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