Long-acting microspheres of Human Chorionic Gonadotropin hormone: In-vitro and in-vivo evaluation

Pawar, Manoj A.; Vora, Lalitkumar K.; Kompella, Prasad; Pokuri, Venkata Kishan; Vavia, Pradeep R.

doi:10.1016/j.ijpharm.2021.121312

Cited by 13 publications

(4 citation statements)

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“…The choice of biomaterial determines the properties and performance of NFMS, influencing factors such as biocompatibility, degradation kinetics, mechanical strength, and bioactivity. Poly(lactic- co -glycolic acid) (PLGA) and polycaprolactone (PCL) are commonly used as the matrix material. , They provide the structural scaffold necessary for NFMS formation while ensuring compatibility with host tissues. , PLGA exhibits a controlled release of encapsulated bioactive molecules and can be tailored to match specific tissue regeneration needs, while PCL possesses favorable mechanical properties, including low modulus and slow degradation rate, making it suitable for load-bearing applications in bone tissue engineering . In addition, materials like collagen, gelatin, and hyaluronic acid (HA) have also been explored .…”

Section: Designing Nfmsmentioning

confidence: 99%

“…Poly(lactic- co -glycolic acid) (PLGA) and polycaprolactone (PCL) are commonly used as the matrix material. 43 , 44 They provide the structural scaffold necessary for NFMS formation while ensuring compatibility with host tissues. 45 , 46 PLGA exhibits a controlled release of encapsulated bioactive molecules and can be tailored to match specific tissue regeneration needs, 47 while PCL possesses favorable mechanical properties, including low modulus and slow degradation rate, making it suitable for load-bearing applications in bone tissue engineering.…”

Section: Designing Nfmsmentioning

confidence: 99%

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Nanofibrous Microspheres: A Biomimetic Platform for Bone Tissue Regeneration

Desai,

Pande,

Vora

et al. 2024

ACS Appl. Bio Mater.

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Bone, a fundamental constituent of the human body, is a vital scaffold for support, protection, and locomotion, underscoring its pivotal role in maintaining skeletal integrity and overall functionality. However, factors such as trauma, disease, or aging can compromise bone structure, necessitating effective strategies for regeneration. Traditional approaches often lack biomimetic environments conducive to efficient tissue repair. Nanofibrous microspheres (NFMS) present a promising biomimetic platform for bone regeneration by mimicking the native extracellular matrix architecture. Through optimized fabrication techniques and the incorporation of active biomolecular components, NFMS can precisely replicate the nanostructure and biochemical cues essential for osteogenesis promotion. Furthermore, NFMS exhibit versatile properties, including tunable morphology, mechanical strength, and controlled release kinetics, augmenting their suitability for tailored bone tissue engineering applications. NFMS enhance cell recruitment, attachment, and proliferation, while promoting osteogenic differentiation and mineralization, thereby accelerating bone healing. This review highlights the pivotal role of NFMS in bone tissue engineering, elucidating their design principles and key attributes. By examining recent preclinical applications, we assess their current clinical status and discuss critical considerations for potential clinical translation. This review offers crucial insights for researchers at the intersection of biomaterials and tissue engineering, highlighting developments in this expanding field.

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Section: Designing Nfmsmentioning

confidence: 99%

Section: Designing Nfmsmentioning

confidence: 99%

Nanofibrous Microspheres: A Biomimetic Platform for Bone Tissue Regeneration

Desai,

Pande,

Vora

et al. 2024

ACS Appl. Bio Mater.

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“…For this reason, a parenteral microsphere system was developed in the form of an implant using poly (lactic-co-glycolic acid) polymer to release the drug continuously and gradually so that the patient does not need to be injected repeatedly [59]. Human chorionic gonadotropin hormone microspheres have also been formulated for a similar purpose to treat fertility problems in women and increase sperm count in men [60].…”

Section: Parenteral Microspheres Drug Delivery Systemmentioning

confidence: 99%

An Up-to-Date Review: Microspheres as a New Drug Delivery System

DESNITA,

NOVIANA,

ZAI

et al. 2023

Int J App Pharm

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The application of microsphere systems in drug preparations has seen a significant increase in recent years for various purposes. Microsphere systems can be utilized in a range of drug preparations, utilizing polymer types that are appropriate for the intended release target. Microspheres offer numerous benefits and can be used in various applications, including spacer applications, medication administration, and medical diagnostics. Microspheres have minimal negative effects, a more extended therapeutic effect, require fewer doses, and provide more consistent medication absorption. Additionally, they are adaptable, offer effective encapsulation, and are cost-effective. This overview was compiled to provide an up-to-date summary of the latest developments in new drug delivery systems utilizing microsphere dosage forms. Literature from Scopus, ScienceDirect, and PubMed from 2019 to 2022 was searched to provide the latest information. The use of microsphere systems is categorized into various new drug delivery routes, including gastroretentive, colon, nasal and pulmonary, parenteral, ocular, and topical applications.

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“…Attaining controlled release via depot systems or by utilizing specialized drug carrier platforms is on the rise and plays a major role in the ever-emerging field of pharmaceuticals and biopharmaceuticals [3,4]. These systems serve as potential alternatives to the conventional drug delivery vehicles in terms of their design to modulate drug release kinetics, safety, efficacy, and achievement of desired bioavailability due to their innovative nature [5][6][7]. Intending to utilize the intrinsic physicochemical properties of nanomaterials, lyotropic liquid crystals (LLC) evolved and have garnered immense interest due to their vast applicability in parenteral, transdermal, topical as well as oral drug delivery systems.…”

Section: Introductionmentioning

confidence: 99%