Lomefloxacin

Abstract

The antibacterial efficacy of oral lomefloxacin has been investigated in a wide variety of infections, including respiratory and uncomplicated and complicated urinary tract infections, obstetric, gynaecological, joint, skin, oral, ear, nose, throat and eye infections. It has also been used as an otic solution in patients with otitis media and as an ophthalmic solution in the treatment of eye infections. In clinical trials its efficacy is equivalent to that of other quinolones and it is at least as effective as other antibacterial drugs ordinarily used in these infections. Lomefloxacin offers certain advantages compared with other quinolone antibacterial drugs in that it may be conveniently administered once daily and theophylline dosage adjustment does not appear to be necessary in patients receiving this bronchodilator concomitantly. Thus, orally administered lomefloxacin should prove a useful broad spectrum antibacterial drug for a wide variety of clinical infections.

Antibacterial and Pharmacological Evaluation of Fluoroquinolones: A Chemoinformatics Approach

“…Ciprofloxacin is on the World Health Organization’s (WHO) “List of Essential Medicines” [ 9 ]. Lomefloxacin is a difluorinated quinolone used to treat bacterial infections including respiratory and urinary tract infections, and skin, eye, throat infections [ 10 ]. Ofloxacin is useful for treating bacterial infections of eye, ear [ 11 ], prostatitis [ 12 ], and certain types of infectious diarrhea [ 13 ].…”

A Sensitive Polymelamine Modified Sensor for the Determination of Lomefloxacin in Biological Fluids

“…LMF exhibits high activity against a wide range of gram-negative and gram-positive bacteria including Citrobacter, Enterobacter, Klebsiella, Proteus, Salmonella, Shigella, Yersinia, Campylobacter, Haemophilus species, Escherichia coli, Neisseriaceae and staphylococci. [1][2][3] LMF inhibits DNA synthesis by promoting double strand breakage of bacterial chromosome supercoiling, which is the result of interference with the bacterial enzyme complex DNA gyrase and topoisomerase IV, responsible for the replication and transcription of bacterial DNA. Prevention of DNA synthesis ultimately results in rapid bacterial death.…”

ChemInform Abstract: Preparation of Novel Pyrrolo[2,3‐b]pyridine Derivatives via a New Concise Synthetic Approach.

“…Quinolones are a known class of synthetic antimicrobial drugs that can be divided into several types based on their chemical structure, including naphthyridinic acids, cinnolinic acids, pyridopyrimidinic acids, and quinolinic acids. Scheme shows some representative drugs with the quinolone core . In addition to these molecules, some analogs containing a pyridine ring fused with a five‐membered ring also exhibit excellent activities, especially antimicrobial activity, such as 4,7‐dihydro‐4‐oxo‐1 H ‐thieno[2,3‐ b ]pyridine‐5‐carboxylic acids ( 1 ) and 4,7‐dihydro‐4‐oxo‐1 H ‐pyrrolo[2,3‐ b ]pyridine‐5‐carboxylic acids ( 2 ) (Figure ).…”

“…Scheme 1 shows some representative drugs with the quinolone core. [1][2][3][4] In addition to these molecules, some analogs containing a pyridine ring fused with a five-membered ring also exhibit excellent activities, especially antimicrobial activity, such as 4,7dihydro-4-oxo-1H-thieno [2,3-b]pyridine-5-carboxylic acids 5 (1) and 4,7-dihydro-4-oxo-1H-pyrrolo [2,3-b]pyridine-5carboxylic acids 6 (2) (Figure 1).…”